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Reproductive and Developmental Toxicology 2nd Edition by Ramesh Gupta ISBN 0128042397 9780128042397

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ISBN 10: 0128042397
ISBN 13: 9780128042397
Author: Ramesh Gupta

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others.

With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife.

Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies.

  • Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development
  • Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment
  • Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Reproductive and Developmental Toxicology 2nd Table of contents:

Section I. General

  • Chapter 1. Introduction

  • Chapter 2. Reproductive Anatomy and Physiology

    • Introduction

    • Important Definitions and Concepts

    • Review of Normal Human Reproduction

    • Concluding Remarks and Future Directions

  • Chapter 3. Pharmacokinetics in Pregnancy

    • Introduction

    • Factors Affecting Pharmacokinetics in Pregnancy

    • The Fetal Compartment

    • Highlighting the Value of PK Information in Pregnancy: Tocolytic Therapy

    • Maternal Disease and Obstetrical Complications

    • Origins of the Knowledge Gap

    • Current Initiatives and Future Directions

    • Physiologically Based Pharmacokinetic Modeling

    • Concluding Remarks and Future Directions

  • Chapter 4. Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology

    • Introduction

    • PBPK Modeling: Basic Concepts and Tools

    • PBPK Modeling in Reproductive and Developmental Toxicology

    • PBPK Model Applications in Reproductive and Developmental Toxicology

    • Concluding Remarks and Future Directions

  • Chapter 5. Drugs and Chemical Contaminants in Human Breast Milk

    • Introduction

    • Breast-Feeding

    • Drug Excretion Into Breast Milk

    • Drug Disposition in the Infant

    • Drugs That Should Be Used With Caution

    • Commonly Used Herbal Products

    • Nonmedicinal Substances

    • Environmental Pollutants

    • Concluding Remarks and Future Directions

Section II. Toxicity Testing Models and Safety Evaluation

  • Chapter 6. Reproductive and Developmental Safety Evaluation of New Pharmaceutical Compounds

    • Introduction

    • Overview of Human Pharmaceutical Development Process

    • Developmental and Reproductive Toxicity Studies Needed

    • Interpretation of Human Risk From Animal Studies

    • Reproductive Risks Communication and Management

    • Concluding Remarks and Future Directions

  • Chapter 7. Juvenile Toxicology Testing

    • Introduction

    • Regulatory Considerations

    • Anatomical and Functional Assessments

    • Concluding Remarks and Future Directions

  • Chapter 8. Postmarket Surveillance and Regulatory Considerations

    • Introduction

    • Drugs Intended for Use in Humans

    • Vaccines Intended for Use in Humans

    • Drugs Intended for Use in Animals

  • Chapter 9. OECD Guidelines for In Vivo Testing

    • Introduction

    • OECD 414–443 Guidelines

    • Other Methods Not Included in OECD Guidelines

    • Concluding Remarks and Future Directions

  • Chapter 10. Guidelines for Risk Assessment of Chemicals

    • Introduction

    • Regulation and Guidelines

    • Risk Assessment Approaches

    • Concluding Remarks and Future Directions

  • Chapter 11. Mechanism-Based Methods for Testing Developmental Toxicity

    • Introduction

    • Validated Alternative Models

    • Nonvalidated Methods

    • Concluding Remarks and Future Directions

  • Chapter 12. Relevance of Animal Testing

    • Introduction

    • Animal Model Choices

    • Nonmammalian Models

    • Toxicity End Points

    • Path to Alternative Tests

    • Concluding Remarks

  • Chapter 13. Embryonic Toxic Lesions and Stem Cell Therapy

    • Introduction

    • Vasculogenesis and Hematopoiesis

    • Correction Experiments

    • Concluding Remarks and Future Directions

  • Chapter 14–18. Alternative Animal Models in Developmental Toxicity

    • Zebrafish

    • Caenorhabditis elegans

    • Primates

Section III. Nanoparticles and Radiation

  • Chapter 19. Engineered Nanomaterials

  • Chapter 20. Ionizing Radiation and Reproductive Effects

Section IV. Gases and Solvents

  • Chapter 21. Solvents and Gases (e.g., Benzene, Formaldehyde)

Section V. Drugs of Abuse, Smoking, and Alcohol

  • Chapter 22. Caffeine

  • Chapter 23. Abused Drugs

  • Chapter 24. Alcohol

  • Chapter 25. Cigarette Smoking

Section VI. Pharmaceuticals and Food Additives

  • Chapters 26–29.

    • Thalidomide

    • Retinoids

    • Melamine and Cyanuric Acid

    • Ionophores

Section VII. Metals

  • Chapters 30–34.

    • Boron

    • Arsenic, Cadmium, Lead

    • Manganese

    • Mercury

    • Selenium

Section VIII. Pesticides, Industrial and Environmental Contaminants

  • Chapters 35–45.

    • Organophosphates, Carbamates

    • Chlorinated Hydrocarbons, Pyrethrins

    • Herbicides and Fungicides

    • Brominated Flame Retardants

    • PCBs, PBBs, Dioxins, Furans

    • PAHs

    • Bisphenol A

    • Ethylene Glycol

    • PFOS and PFOA

    • Phthalates

    • Personal Care Products

Section IX. Phytotoxins, Mycotoxins, Zootoxins

  • Chapters 46–49.

    • Toxic Plants

    • Fumonisins

    • Aflatoxins, Ochratoxins, Citrinin

    • Zootoxins

Section X. Special Topics

  • Chapters 50–57.

    • Systems Toxicology

    • Stem Cell Testing

    • Epigenetics

    • Mitochondrial Dysfunction

    • Cell Signaling

    • Neuroinflammation

    • Cholesterol Disruption

Section XI. Endocrine Disruption, Mutagenicity, Infertility, Teratogenicity

  • Chapters 58–63.

    • Endocrine Disruption

    • Disorders and Testicular Toxicity

    • Mutagenicity and Reproductive Cancers

    • Neural Tube Defects

    • Teratogenicity

    • Micro-CT and Imaging

Section XII. Toxicologic Pathology

  • Chapter 64. Reproductive Toxicologic Pathology

Section XIII. Placental Toxicity

  • Chapters 65–69.

    • Placental Programming

    • Hemochorial Placentation

    • ABC Transporters

    • Placental Toxicity

    • Placental Pathology

Section XIV. Domestic and Wildlife Species

  • Chapters 70–72.

    • Avian Species

    • Wildlife

    • Livestock Teratogenesis

Index

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Tags: Ramesh Gupta, Developmental Toxicology, Reproductive