Cancer And Inflammation Mechanisms Chemical Biological And Clinical Aspects 1st edition by Yusuke Hiraku ISBN 1118826553 9781118826553

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ISBN 10: 1118826553
ISBN 13:  9781118826553
Author: Yusuke Hiraku

A new perspective on the link between inflammation and cancer Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.

Cancer And Inflammation Mechanisms Chemical Biological And Clinical Aspects 1st Table of contents:

SECTION I GENERAL OVERVIEW OF INFLAMMATION-RELATED CANCER

CHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW

INFECTION, INFLAMMATION, AND CANCER: POSSIBLE MECHANISMS

PRODUCTION OF INFLAMMATORY MEDIATORS AND REACTIVE OXIDANTS

DNA AND PROTEIN DAMAGE BY ROSs AND RNSs

INFLAMMATION, EPIGENETIC MODIFICATION, AND microRNA

CONCLUDING REMARKS

REFERENCES

CHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER

CHRONIC INFLAMMATION AND CANCER

CANCER STEM CELLS

CARCINOGENIC FACTORS ARISING FROM CHRONIC INFLAMMATION

CHRONIC INFLAMMATION AND NORMAL STEM CELL FUNCTION

INFLAMMATION AND THE DEVELOPMENT AND REGULATION OF CANCER STEM CELLS

CONCLUDING REMARKS

REFERENCES

CHAPTER 3 EPITHELIAL–MESENCHYMAL TRANSITION: A LINK BETWEEN CANCER AND INFLAMMATION

EMT: A LINK BETWEEN CANCER AND INFLAMMATION

Q1: HOW ARE EMT-PERMISSIVE, INFLAMMATORY TUMOR MICROENVIRONMENTS CREATED?

Q2: WHICH EMT-PROMOTING SIGNALS ARE PROVIDED BY INFLAMMATORY TUMOR MICROENVIRONMENTS?

Q3: HOW DO EMT-PROMOTING SIGNALS INFLUENCE THE MIGRATORY BEHAVIOR OF TUMOR CELLS?

CONCLUSIONS AND FUTURE PROSPECTS

REFERENCES

SECTION II BIOCHEMISTRY IN INFLAMMATION-RELATED CANCER

CHAPTER 4 ROLE OF NITRATIVE DNA DAMAGE IN INFLAMMATION- RELATED CARCINOGENESIS

DNA DAMAGE DURING CHRONIC INFLAMMATION

LIVER FLUKE–INDUCED CHOLANGIOCARCINOMA

HPV-INDUCED CERVICAL CANCER

EBV-INDUCED NASOPHARYNGEAL CARCINOMA

DNA DAMAGE INDUCED BY ASBESTOS EXPOSURE

DNA DAMAGE INDUCED BY CARBON NANOTUBE

SOFT TISSUE TUMORS AND PROGNOSIS OF TUMOR PATIENTS

CONCLUSIONS AND FUTURE PROSPECTS

REFERENCES

CHAPTER 5 LIPID PEROXIDATION–DERIVED DNA ADDUCTS AND THE ROLE IN INFLAMMATION-RELATED CARCINOGENESIS

LPO-DERIVED REACTIVE PRODUCTS CONTRIBUTE TO DNA DAMAGE

RESULTS AND DISCUSSION

CONCLUSIONS AND FUTURE PROSPECTS

REFERENCES

CHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMAN TISSUES

LEVEL OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS IN HUMAN TISSUES

BIOLOGICAL PROPERTIES OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS

INFLAMMATION AND FORMATION OF 4-ONE

CONCLUDING REMARKS

REFERENCES

SECTION III MOLECULAR BIOLOGY IN INFLAMMATION-RELATED CANCER

CHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER

TLRs AND THEIR LIGANDS

TLR SIGNALING

MYD88-DEPENDENT SIGNALING PATHWAYS

TRIF-DEPENDENT SIGNALING PATHWAYS

INNATE IMMUNE CELLS IN CANCER TISSUES

TLRs AND TUMOR MICROENVIRONMENT

TOLL-LIKE RECEPTORS IN CANCER AND TUMOR THERAPY

ANTITUMOR ACTIVITY OF TLR LIGANDS

ROLES OF TLRs IN CANCER PROGRESSION

CURRENT AND FUTURE DEVELOPMENTS

REFERENCES

CHAPTER 8 INFLAMMASOMES AND INFLAMMATION

NOD-LIKE RECEPTORS AND THE INFLAMMASOMES

THE NLRP3 INFLAMMASOME

THE IPAF INFLAMMASOME

THE NLRP1 INFLAMMASOME

THE NLRP12 INFLAMMASOME

THE NLRP7 INFLAMMASOME

THE NLRP6 INFLAMMASOME

THE AIM2 INFLAMMASOME

CYTOKINE TARGETS OF THE INFLAMMASOME

INFLAMMASOME DYSREGULATION IN DISEASE

CONCLUDING REMARKS

REFERENCES

CHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSIC GENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT

PHYSIOLOGICAL ROLE OF ACTIVATION-INDUCED CYTIDINE DEAMINASE

ABERRANT EXPRESSION OF AID IN INFLAMMATORY TISSUES

MECHANISMS FOR AID EXRESSION BY H. PYLORI AND HCV CORE PROTEIN

INDUCTION OF GENOMIC INSTABILITY BY AID

LESSONS FOR CANCER RESEARCH IN THE STUDY OF AID

SUMMARY

REFERENCES

CHAPTER 10 MicroRNA AND INFLAMMATION-RELATED CANCER

BIOGENESIS AND FUNCTION OF miRNAs

miRNAs AS MEDIATORS OF INFLAMMATION-INDUCED CANCINOGENESIS

miRNAs INVOLVEMENT IN THE METASTASIS OF INFLAMMATION-RELATED CANCERS

SINGLE-NUCLEOTIDE POLYMORPHISMS AMONG miRNAs AND INFLAMMATION-RELATED CANCER SUSCEPTIBILITY

VIRUS-ENCODED miRNAs AND INFLAMMATION-RELATED CANCERS

FUTURE PROSPECTS

REFERENCES

CHAPTER 11 INFLAMMATION AS A NICHE FOR TUMOR PROGRESSION

INFLAMMATION CONVERTS A PRIMARY TUMOR ENVIRONMENT TO A FAVORABLE SPOT FOR TUMOR PROGRESSION

INFLAMMATORY CELL COMPONENTS NECESSARY TO ACCELERATE TUMOR PROGRESSION

INFLAMMATORY CELL–DERIVED FACTORS NECESSARY TO ACCELERATE TUMOR PROGRESSION

EXPERIMENTAL MODEL OF INFLAMMATION-BASED TUMOR PROGRESSION

CONCLUSIONS AND FUTURE PROSPECTS

REFERENCES

SECTION IV INFLAMMATION-RELATED CANCER INDUCED BY SPECIFIC CAUSES

CHAPTER 12 HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER

SYMPTOMS AND CLASSIFICATION OF CERVICAL CANCER

HUMAN PAPILLOMAVIRUS AND CERVICAL CARCINOGENESIS

THERAPEUTIC INTERVENTIONS

REFERENCES

CHAPTER 13 HEPATITIS VIRUSES AND HEPATOCELLULAR CARCINOMA

HBV

HCV

ENVIRONMENTAL AND METABOLIC FACTORS AND INTERACTION WITH HBV AND HCV

CONCLUDING REMARKS

REFERENCES

CHAPTER 14 EPSTEIN–BARR VIRUS AND NASOPHARYNGEAL CARCINOMA

MOLECULAR BIOLOGY OF EBV

EBV AND NPC

REFERENCES

CHAPTER 15 BARRETT’S ESOPHAGUS AND ESOPHAGEAL CANCER

HISTOLOGICAL DIAGNOSIS OF BARRETT’S-RELATED DYSPLASIA AND BARRETT’S-ASSOCIATED CANCER

ROLE OF MOLECULAR PREDICTORS FOR BARRETT’S CARCINOGENESIS

THE LINK BETWEEN BARRETT’S CARCINOGENESIS AND INFLAMMATION

INFLAMMATION AND GENETIC ALTERATIONS IN BARRETT’S CARCINOGENESIS

INFLAMMATION AND EPIGENETIC ALTERATIONS IN BARRETT’S CARCINOGENESIS

CONCLUDING ASSESSMENT OF INFLAMMATION AND BARRETT’S CARCINOGENESIS

REFERENCES

CHAPTER 16 ASBESTOS-INDUCED CHRONIC INFLAMMATION AND CANCER

ASBESTOS AND ASBESTOS-LIKE FIBERS: OLD AND NEW HAZARDS

GENES MAY MODULATE THE RISK OF ASBESTOS-RELATED DISEASES

ASBESTOS, INFLAMMATION, AND CARCINOGENESIS

TARGETING ASBESTOS-INDUCED CHRONIC INFLAMMATION

REFERENCES

CHAPTER 17 NANOMATERIALS

POTENTIAL HEALTH EFFECTS OF NMs

OXIDATIVE STRESS AND NMs

INFLAMMATION AND NMs

GENOTOXICITY OF NMs

CARCINOGENICITY OF NMs

EPIGENETIC EFFECTS OF NMs

CONCLUDING REMARKS

REFERENCES

CHAPTER 18 INFLAMMATORY PATHWAYS OF RADIATION-INDUCED TISSUE INJURY

INTERACTION OF IR WITH CELLS AND TISSUES

BIOLOGICAL EFFECTS OF IR

TYPES OF RADIATION EFFECTS

DNA DAMAGE: CHROMOSOMAL INSTABILITY

CLUSTERED DNA DAMAGES

SIGNIFICANT CONTRIBUTION OF INFLAMMATION IN THE CHRONIC LATE EFFECTS OF RADIATION

INFLAMMATION AND RADIATION-INDUCED NONTARGETED EFFECTS

RADIATION-INDUCED UP-REGULATION OF INFLAMMATORY MEDIATORS

CENTRAL NERVOUS SYSTEM

CIRCULATORY SYSTEM

LUNG

CONCLUDING REMARKS

REFERENCES

CHAPTER 19 PHOTOCARCINOGENESIS AND INFLAMMATION

DNA DAMAGE CAUSED BY SUNLIGHT

UV-INDUCED DNA LESIONS AND MUTATIONS IN SKIN CANCERS

UV-INDUCED INFLAMMATION AND SKIN CANCERS

DNA DAMAGE AND INFLAMMATION

DIFFERENCE BETWEEN CHEMICALLY INDUCED CANCER AND PHOTOCARCINOGENESIS

MELANOMA AND UV-INDUCED INFLAMMATION

THE ROLE OF UVA IN PHOTOCARCINOGENESIS

DEVELOPMENT OF SKIN CANCER IN GENETIC DISORDERS

UV-INDUCED IMMUNE SUPPRESSION

REFERENCES

SECTION V PREVENTION OF INFLAMMATION-RELATED CARCINOGENESIS

CHAPTER 20 CHEMOPREVENTION OF COLORECTAL CANCER BY ANTI-INFLAMMATORY AGENTS

ANTI-INFLAMMATORY AGENTS TARGETING CYCLOOXYGENASE

ANTI-INFLAMMATORY AGENTS TARGETING iNOS

ANTI-INFLAMMATORY AGENTS TARGETING PPAR-γ

OTHER CANDIDATES AS CANCER CHEMOPREVENTIVE AGENTS WITH ANTI-INFLAMMATORY POTENTIAL

FUTURE PROSPECTS

REFERENCES

CHAPTER 21 NUTRACEUTICALS AND COLON CANCER PREVENTION

PATHOGENESIS OF COLON CANCER

CHEMOPREVENTIVE MECHANISMS BY NUTRACEUTICALS

EXPERIMENTAL MODELS OF COLON CARCINOGENESIS IN CHEMOPREVENTION

NUTRACEUTICAL AND COLON CANCER

CONCLUDING REMARKS

REFERENCES

CHAPTER 22 CANCER CHEMOPREVENTION TARGETING COX-2 USING DIETARY PHYTOCHEMICALS

COX-2 AND CANCER

TRANSCRIPTIONAL REGULATION OF COX-2 EXPRESSION

CHEMOPREVENTIVE PHYTOCHEMICALS TARGETING COX-2

OTHER POTENTIAL TARGETS FOR INHIBITION OF THE PG SYNTHESIS SIGNALING

POSITIVE FEEDBACK LOOP BETWEEN COX-2 AND EP RECEPTORS

PHYTOCHEMICALS TARGETING EPs

CONCLUDING REMARKS

REFERENCES

CHAPTER 23 REGULATION OF INFLAMMATION-ASSOCIATED INTESTINAL DISEASES WITH PHYTOCHEMICALS

DEXTRAN SULFATE SODIUM–INDUCED MOUSE COLITIS MODEL

CXCL16 AS THE CELL SURFACE RECEPTOR FOR DSS

REGULATION OF COLITIS WITH NATURALLY OCCURRING FLAVONOIDS

OBESITY-ASSOCIATED CRC

SUPPRESSIVE EFFECTS OF NOBILETIN ON INFLAMMATION-ASSOCIATED CRC

CONCLUDING REMARKS

REFERENCES

INDEX

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Tags: Yusuke Hiraku, Inflammation Mechanisms, Chemical Biological, Clinical Aspects