Cord Blood Stem Cells and Regenerative Medicine 1st edition by Stavropoulos, Catherine, Charron, Dominique, Navarrete, Cristina 0124078362 9780124077850 9780124078369

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ISBN-10 ‏ : ‎0124078362

ISBN-13 ‏ : ‎ 9780124077850, 9780124078369

Author:   Stavropoulos-Giokas, Catherine; Charron, Dominique; Navarrete, Cristina 

Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic.

 

Cord Blood Stem Cells and Regenerative Medicine 1st Table of contents:

Section I. Introduction

Chapter 1. Introduction to Cord Blood Stem Cells

Section II. Cord Blood Cells Biology

Chapter 2. Cord Blood Content

1. Biological Background of Cord Blood Cells—Development of Hematopoietic and Nonhematopoietic Cells

2. Endothelial Cells in CB

3. Stromal Cells in CB and Cord Tissue as Compared to BM

4. Isolation, Expansion, and Characterization of CB-derived Adherent Cells from CB

5. Generation of Cell Clones and Clonal Populations

6. USSC and CB MSC

7. Generation of Adherent Cells from the Wharton’s Jelly (Cord)

8. Gene Expression Profiles

9. Correlation of HOX-gene Expression and Regenerative Potential

10. Bone and Cartilage Forming Potential of Cord Blood Stromal Cells

11. Why Do We Have These Progenitors or Elusive Cells in CB?

12. USSC and MSC from CB Support Hematopoietic Cells

13. Liver Regeneration and Potential of CB-derived Stem Cells to Undergo Hepatic Differentiation

14. Cardial Regeneration In vivo

15. In vitro Differentiation Potential toward Cardiomyocytes

16. CB Subpopulations for Neuronal Regeneration

17. Reprogrammed Subpopulations from CB

18. Conclusion

List of Acronyms and Abbreviations

Chapter 3. Cord Blood Hematopoiesis: The Road to Transplantation

1. Use of Placental Cord Blood as a Source for Hematopoietic Stem/Progenitor Cells Transplantation: A Historical Perspective

2. Characterization of PCB HSPCs

3. Strategies to Overcome Current Limitations in PCB Transplantation

4. Increasing the HSPCs of the Graft

5. Improving the Lodging Capacity of the PCB Graft

6. Improving the Stem Cell Receptivity or Immunological Status of the Host

7. Additional Clinical Uses of Cord Blood under Investigation

8. Concluding Remarks

Chapter 4. Immunobiology of Cord Blood Cells

1. Introduction

2. Immune Properties of Cord Blood Cells

3. Immune Reconstitution after CBT

4. Generation of Immune Competent Cells from Cord Blood

5. Conclusion

List of Abbreviations

Chapter 5. Cord and Cord Blood-derived Endothelial Cells

1. Introduction

2. The Human Endothelial Colony-Forming Cell Hierarchy

3. Differences Between Human Umbilical Cord Blood ECFCs and Those Sourced from Adult Peripheral Blood, Umbilical Cord, and Placenta

4. Obstetric Factors and ECFC Content in Umbilical Cord Blood at Term

5. ECFC Content and Function in Umbilical Cord Blood Based on Gestational Age

6. The Diabetic Environment Affects Umbilical Cord Blood ECFCs

7. Processing and Cryopreservation Affect ECFC Numbers in Umbilical Cord Blood

8. The Phenotypic Identity of ECFCs

9. The Use of Umbilical Cord Blood or Placental ECFCs as a Cellular Product in Regenerative Medicine

10. Conclusions

Glossary

List of Acronyms and Abbreviations

Chapter 6. HLA and Immunogenetics in Cord Blood Transplantation

1. Introduction

2. Structure, Function, and Polymorphism of HLA

3. HLA Typing Techniques

4. CBT Results

5. Other HLA Criteria for CBU Selection

6. Conclusion

List of Abbreviations

Section III. Cord Blood Cells for Clinical Use

Chapter 7. Clinical Use of Umbilical Cord Blood Cells

1. Introduction

2. Clinical CB Transplantation

3. Clinical Use of Related CB Cells for Allogeneic Transplantation

4. Clinical Use of Unrelated CB Cells for Allogeneic Transplantation

5. Selection of CB Units for Transplantation

6. New Strategies to Improve Outcomes after CB Transplantation

7. Conclusion

List of Acronyms and Abbreviations

Chapter 8. Immunodeficiencies and Metabolic Diseases

1. Immunodeficiencies

2. Metabolic Diseases

Chapter 9. Cord Blood Cells and Autoimmune Diseases

1. Introduction

2. New Insights in the Pathogenesis of ADs

3. Hematopoietic Stem Cell Transplantation for the Treatment of AD

4. Use of UCB-derived Cells and Cord Blood MSCs for Treating AD

5. Conclusion

Chapter 10. Umbilical Cord as a Source of Immunomodulatory Reagents

1. Regulatory T-cells

2. Mesenchymal Stromal Cells

3. Conclusions

Chapter 11. Cord Blood Cells for Clinical Use: Expansion and Manipulation

1. Introduction

2. CB Transplantation in Pediatric Patients

3. CB Transplantation in Adult Patients

4. Double CB Transplantation

5. CB Transplantation after Reduced Intensity Regimens

6. CB Graft Manipulation

7. CB Stem Cell and Progenitor Cell Expansion to Enhance Engraftment

8. Improving CB Homing to BM

9. Prostaglandin and Homing

10. CB Immune Cells to Improve Outcome

11. Expanding Multivirus-Specific Cytotoxic T Lymphocytes from CB

12. CB-Derived Natural Killer (NK) Cells

13. CB-Derived Regulatory T Cells

14. Redirecting Specificity of CB-Derived T Cells to Leukemia Antigens

15. Conclusion

Chapter 12. Cord Blood Stem Cells for Clinical Use: Diabetes and Cord Blood

1. Diabetes and Global Challenges

2. Stem Cells in Cord Blood

3. Application of Stem Cell Educator Therapy in T1D

4. Application of Stem Cell Educator Therapy in Type 2 Diabetes

5. Conclusions

Dr Yong Zhao’s Bibliography

Section IV. Regenerative Medicine Applications

Chapter 13. Emerging Uses of Cord Blood in Regenerative Medicine–Neurological Applications

1. Introduction

2. Umbilical CB as a Source of Stem Cells for Neurological Applications

3. Potential Mechanisms of CB as Therapy for Patients with Neurological Diseases

4. Unrelated Donor CB Transplantation for Genetic Brain Diseases in Children

5. Ischemic Injuries

6. Neurodegenerative Diseases

7. Autism

8. Challenges

9. Summary

Chapter 14. Biobanks for Induced Pluripotent Stem Cells and Reprogrammed Tissues

1. Introduction: A Brief History of Induced Pluripotency

2. What Defines Pluripotency and the Pluripotent Stem Cell

3. Reprogramming Human Somatic Cells Toward Induced Pluripotent Stem Cells Using Defined Factors

4. Tissue Differentiation from hiPSCs

5. Potential Applications for hiPSCs in Future Regenerative Medicines

6. Considerations Toward Development of hiPSC-derived Therapies

7. Final Considerations

Section V. Cord Blood Banking: A Current State of Affairs

Chapter 15. Cord Blood Banking: Operational and Regulatory Aspects

1. Introduction

2. Conclusions

Chapter 16. Cord Blood Unit Selection for Unrelated Transplantation

1. Overview: Search and Cord Blood Unit Selection

2. Quality/Potency of the CBU

3. Selection of CB Units for Transplant: Interaction of TNC and HLA

4. Selection of CBU with “Permissible” HLA Mismatches

5. Approaches to Overcome the TNC Limitations of Single CB Grafts

6. Quality of CBU—Banking Practices

7. Patient Diagnosis, Relapse Risk, and CBU Selection

8. Other Immunological Considerations for CBU Selection

9. Other Graft Characteristics Affecting CBU Quality and Safety

10. “Back-up” CB Grafts

11. Conclusions—Selection Guidelines

Chapter 17. Quality Management Systems Including Accreditation Standards

1. Introduction

2. Quality Management

3. QM Systems

4. Creating a Documented Quality Management System (Program): Quality Management Plan

5. Standardized Systems

6. Accreditation

7. Conclusion

Abbreviations

Chapter 18. Regulation Across the Globe

1. Introduction

2. Regulation in the EU

3. Cord blood banking in the USA

4. Cord blood banking in Asia, Africa, and Oceania

5. Conclusion

Chapter 19. International Development and Import/Export–WMDA

1. Introduction

2. Issues to Consider when Starting a Cord Blood Bank

3. Listing of Cord Blood Units—Making them Available to Transplant Units

4. Registry—Gateway to the World

5. Search for Cord Blood

6. Challenges Related to the Provision of Cord Blood—Selection

7. Challenges Related to the Provision of Cord Blood—Service Provider

8. Challenges Related to the Provision of Cord Blood—Regulation

9. Cord Blood Banks Worldwide

10. Analyzing the Field—Number of Cord Blood Shipments

11. Future Plans for Cord Blood Banks

12. List of Cord Blood Registries/Banks

Section VI. Cord Blood Banking: Current and Future Outlooks

Chapter 20. Allogeneic and Autologous Cord Blood Banks

1. A “Perfect” Match?

2. Stem Cell Trans-differentiation and Tissue Repair?

3. Source and Quality of Information

4. Maternal and Paternal Knowledge and Preferences

5. Conclusions: What is the Current “Child’s Best Interest”?

Conflict of Interest

Chapter 21. The Future of Cord Blood Banks

1. Introduction

2. CB and Fetal Annex Tissues are an Abundant Source of “Young” Stem Cells

3. CB-derived EPCs

4. UC Wharton’s Jelly MSCs

5. The iPSCs

6. CB and UC Components

7. Conclusion

List of Abbreviations

Section VII. The Viewpoint of Society

Chapter 22. An Introductory Note to the Cord Blood Banking Issues in a European and International Environment

Chapter 23. Ethical and Legal Issues in Cord Blood Stem Cells and Biobanking

1. Introduction

2. Scientific Background: Stem Cells from Cord Blood, the Umbilical Cord, and the Placenta

3. Fundamental Ethical and Legal Issues

4. The Status of the Umbilical Cord and the Placenta

5. Legislative Characterizations of Stem Cells from Cord Blood, the Umbilical Cord, and the Placenta

6. Informed Consent

7. Communication of Information to the Donor of Cord Blood, Umbilical Cord, and Placenta Regarding Likely Diseases

8. The Donation of Cord Blood, Umbilical Cord, and Placenta and Noncommercialization

9. Anonymity—Anonymization of Donation and Protection of Data

10. “Biological Safety” of the Donor and Biobanking

11. Regenerative Medicine and Mesenchymal Cells of the Umbilical Cord and the Placenta

12. Conclusion

Chapter 24. Industrial Economics of Cord Blood Banks

1. Types of Cord Blood Banks

2. Emergence of Hybrid Models

3. Economic Model of Public Banks

4. Economic Model of Commercial Banks

5. Attitudes and Knowledge of Pregnant Women

6. Cost Analysis for Public Banks

7. Cost Analysis for Private Banks

8. The Emergence of Bioinsurance

9. Cost-utility for Public Health

10. Tissue Economies

11. Rethinking the Business Model of Private Banks

Chapter 25. Public Health Policies in European Union: An Innovation Strategy–Horizon 2020

1. Introduction

2. The Configuration Framework of Guiding Principles of Health Policies

3. The Health Status of the Population in the EU

 

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