Cold Atmospheric Plasmas Their Use In Biology And Medicine 1st edition by Spencer Kuo – Ebook PDF Instant Download/Delivery: 9813279842, 978-9813279841
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ISBN 10: 9813279842
ISBN 13: 978-9813279841
Author: Spencer Kuo
Cold atmospheric plasma (CAP) generators have been actively developed as a new device for medical treatment. The applications of plasma treatment include 1) disinfection, sterilization, and decontamination, which inactivates or kills bacteria, fungi, viruses and spores; 2) bleeding control, which coagulates blood swiftly; 3) wound healing, which shortens the healing period and benefits the regeneration of the epithelization of tissue to avoid scar formation; etc.Biomedical applications of CAPs are explored via either in-vitro assays, or in-vivo tests using pigs as animal models; tests include sterilization of oral pathogens and biofilm, decontamination of biological warfare agent, blood clotting and rapid control of active life-threatening hemorrhage, and post-operative observation of wound healing after plasma treatment. The conventional approaches in each application are first introduced, then the advantages of plasma treatments are discussed and demonstrated by the test results. The mechanisms of CAPs’ biocidal effect, blood clotting effect, and wound healing effect are presented and discussed.
Cold Atmospheric Plasmas Their Use In Biology And Medicine 1st Table of contents:
1 Introduction
1.1 Characteristics of Atmospheric Plasma
1.2 Plasma Medicine Applications
1.2.1 Disinfection and sterilization
1.2.2 Decontamination
1.2.3 Bleeding control
1.2.4 Wounds healing
Problems
2 Atmospheric Pressure Plasma Generators
2.1 Dielectric-barrier Discharges (DBDs)
2.2 Atmospheric Pressure Plasma Jets (APPJs)
2.3 Arc Seeded Microwave Plasma (ASMP)
2.4 Air Plasma Spray (APS)
Problems
3 Free Radicals and Reactive Oxygen Species in Cold Atmospheric Plasma
3.1 Biocidal Effects of Free Radicals and Reactive Oxygen Species
3.2 Plasma-liquid Interaction to Generate Additional Free Radicals and Reactive Oxygen Species
3.3 Emission Lines of Likely Reactive Species in CAAPs
3.4 Emission Spectroscopy of Atomic Oxygen
3.5 Emission Spectroscopy of Electron Excitation Temperature
3.6 Impacts of Atomic Oxygen, Ozone, Nitric Oxide, and UV Radiation
Problems
4 Plasma Disinfection and Sterilization
4.1 Bacteria
4.2 Issues of Disinfection Methods
4.3 Plasma Disinfection Approaches
4.4 CAPs on Dental Issues
4.5 Experiments
4.6 Air Plasma Treatment of Oral Pathogens
4.6.1 Experimental conditions
4.6.2 Zone of inhibition of microorganisms by plasma treatment
4.7 Dental Disinfection
4.7.1 Experiment preparation and procedure
4.7.1.1 Plasma treatment effect on biofilm formation
4.7.1.2 Plasma treatment effect on biofilm disinfection
4.7.2 Experimental results
4.7.2.1 On preventing biofilm formation (case A)
4.7.2.2 On biofilm disinfection (case B)
4.7.2.3 Microscope observation
4.8 Summary
4.9 Discussion
4.10 Cancer Treatment
Problems
5 Plasma Decontamination
5.1 Background
5.2 Spores
5.2.1 Resistance to the treatments
5.3 Decontamination via Biological Reactions
5.4 Experimental Preparations
5.4.1 Experimental setup
5.4.2 Materials
5.4.3 Sample preparations prior to and after exposure
5.4.3.1 Prior to exposure
5.4.3.2 Procedures of processing the samples after plasma treatment
5.5 Colony-forming Unit (CFU)
5.6 Decontamination Experiments and Results
5.6.1 Dry samples on glass slide-coupons
5.6.2 Wet samples
5.6.3 Sample contained inside an envelope
5.7 Morphological Studies
5.7.1 Scanning electron microscopy
5.7.2 Atomic force microscopy
5.8 Plausible Mechanism
5.9 Applications in Other Emerging Areas
5.9.1 Water treatment
5.9.2 Food industry
Problems
6 Effect of Air Plasma on Blood Coagulation
6.1 Blood Coagulation
6.2 In-Vitro Tests of Air Plasma Blood Coagulation
6.3 Tests on Smeared Blood Samples-Cell Count Dependency
6.4 Mechanism of Air Plasma Blood Coagulation
Problems
7 Air Plasma Bleeding Control Study with Animal Models
7.1 Background
7.2 Bleeding
7.3 Hemostasis
7.4 Clotting
7.5 Experimental Arrangement
7.6 Surface Wounds
7.6.1 Test 1 — straight cut
7.6.2 Test 2 — cross cut
7.7 Vessel Wounds
7.7.1 Test 3 — hole in a saphenous vein
7.7.2 Test 4 — a cut to an artery
7.8 Discussion
Problems
8 Wound Healing
8.1 Healing Process
8.2 Immune System
8.3 Post-Operative Observation of Wound Healing After APS Plasma Treatment
8.4 A Plausible Mechanism
8.5 Discussion
8.6 Chronic Wounds
8.7 Burn Wounds
8.8 Wound Care
Problems
9 Advanced Bleeding Control
9.1 Background
9.2 Hemostasis in Combat Casualties
9.3 APS as an Advanced First Aid Tool
9.4 Animal Model Trials
9.4.1 Trial 1 — a deep cut at back
9.4.2 Trial 2 — a curved large cut in hind quarters area
9.4.3 Trial 3 — amputated leg
9.5 Proposed Battlefield Simulation Trials
9.5.1 Proposed Trial 1 — close range shotgun wound to rear leg
9.5.2 Proposed Trial 2 — close range 7.62 mm gunshot through upper rump with large exit wound through groin
9.5.3 Proposed Trial 3 — dissection and laceration of femoral artery
9.5.4 Proposed Trial 4 — dissection and complete severing of brachial artery
9.6 Discussion
9.7 Summary
Problems
Bibliography
Index
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Tags: Spencer Kuo, Cold Atmospheric, Their Use