Molecular Genetics of Liver Neoplasia 1st edition by Xin Wei Wang, Joe Grisham, Snorri Thorgeirsson – Ebook PDF Instant Download/Delivery: 1461427312, 978-1461427315
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Product details:
ISBN 10: 1461427312
ISBN 13: 978-1461427315
Author: Xin Wei Wang, Joe Grisham, Snorri Thorgeirsson
Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.
Molecular Genetics of Liver Neoplasia 1st Table of contents:
1. Introduction
1. Biology of Hepatocellular Carcinoma: Past, Present and Beyond
2. Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum
2. Liver Development And Pathogenesis
3. Pathology of Hepatocellular Carcinoma
3. Genetics And Epidemiology Of Liver Cancer
4. Epidemiology of Hepatocellular Carcinoma
5. Genetics and Epidemiology of Cholangiocarcinoma
4. Molecular Basis Of Cancer Susceptibility
6. Signaling Pathways in Viral Related Pre-neoplastic Liver Disease and Hepatocellular Carcinoma
7. Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinoma
8. DNA Methylation Status in Chronic Liver Disease and Hepatocellular Carcinoma
5. Animal Models
9. Transgenic and Knockout Mouse Models of Liver Cancer
10. Mosaic Cancer Mouse Models and Functional Oncogenomics in Hepatocellular Carcinoma
11. The Zebrafish Model for Liver Carcinogenesis
6. Global Gene Expression Profiling Of Human Liver Cancer
12. Integrative and Functional Genomics of HCC
13. Molecular Signatures of Hepatocellular Carcinoma Metastasis
14. Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumors
7. Cancer Stem Cells
15. Cancer Stem Cells and Liver Cancer
16. Heterogeneity of Liver Cancer Stem Cells
17. Cancer Stem Cells in Liver Carcinoma
8. Liver Cancer Genetics In The Clinic
18. Molecular Signaling in Hepatocellular Carcinoma
19. Molecular Events on Metastasis of Hepatocellular Carcinoma
20. Molecular Pathogenesis of Hepatocellular Carcinoma
Backmatter
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Tags: Xin Wei Wang, Joe Grisham, Snorri Thorgeirsson, Molecular Genetics, Liver Neoplasia