Handbook of Parkinson’s Disease 5th Edition Edited By Rajesh Pahwa, Kelly Lyons – Ebook PDF Instant Download/Delivery: 1841849089, 9781841849089
Full download Handbook of Parkinson’s Disease 5th edition after payment
Product details:
ISBN 10: 1841849089
ISBN 13: 9781841849089
Author: Rajesh Pahwa, Kelly Lyons
This volume has long prevailed as one of the leading resources on Parkinson’s disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD.
Reflecting the many advances that have taken place in the management of PD, this volume promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies.
Handbook of Parkinson’s Disease 5th Table of contents:
1. Early iconography of Parkinson’s disease
Historical and Literary Precedents
James Parkinson
Jean-Martin Charcot and The Salpêtrière School
Other Nineteenth Century Contributions
References
2. Epidemiology
Introduction
Case Definition In Epidemiology: Parkinsonism and Parkinson’s Disease
Prevalence and Incidence of Parkinson’s Disease
Survival and Cause of Death In Parkinson’s Disease
Comorbidity In Parkinson’s Disease
Cancer
Gout/Uric Acid
Diabetes, Hypertension, Hypercholesterolemia, and Other Vascular Diseases
Etiology of Parkinson’s Disease: Genetics, Environment, and Gene–Environment Interaction
Genetics
Environment
Gene–Environment Interaction
References
3. Differential diagnosis
Idiopathic Parkinson’s Disease
Conditions Mimicking Parkinsonism
Other Causes of Parkinsonism
Drug-Induced Parkinsonism
Progressive Supranuclear Palsy
Multiple System Atrophy
Dementia with Lewy Bodies
Corticobasal Degeneration
Frontotemporal Dementia with Parkinsonism
Toxin-Induced Parkinsonism
Posttraumatic Parkinsonism
Multi-Infarct Parkinsonism
Parkinsonism with Hydrocephalus
Parkinsonism Due to Structural Lesions of the Brain
Infectious and Postinfectious Causes of Parkinsonism
Psychogenic Parkinsonism
Parkinsonism In Young Adults
Dopa-Responsive Dystonia
Wilson’s Disease
Neurodegeneration with Brain Iron Accumulation 1
Juvenile Huntington’s Disease
Hemiparkinsonism–Hemiatrophy Syndrome
X-linked Dystonia Parkinsonism (Lubag)
Neuroacanthocytosis
Diagnostic Criteria For Parkinson’s Disease
The Emerging Role of Neuroimaging in the DifferentialDiagnosis of Parkinson’s Disease
References
4. Pathophysiology and clinical assessment
Introduction
Bradykinesia
Tremor
Rigidity and Postural Abnormalities
Postural Instability
Freezing and Other Gait Abnormalities
Other Motor Manifestations
Assessment of Disability
References
5. Premotor symptoms
Introduction
Pathologic Basis and Timeline of Symptoms
Premotor Symptoms of Parkinson’S Disease
Olfactory Dysfunction
Constipation
Sleep Disorders
Depression and Anxiety
Autonomic and Cardiac Dysfunction
Neuroimaging Methods
Screening For Pd With Premotor Symptoms
References
6. Autonomic dysfunction and management
Frequency of Autonomic Dysfunction in PD
Diagnostic Testing For Autonomic Dysfunction In PD
[123I]Metaiodobenzylguanidine ScintigraphyAutonomic Testing
Symptoms and Management of Autonomic Dysfunction In PD
Orthostatic Hypotension
Dysphagia
Sialorrhea
Constipation
Urinary Bladder Dysfunction
Sexual Dysfunction
Sweating Dysfunction
Summary
References
7. Sleep dysfunction
Introduction
Epidemiology
Pathophysiology
Symptoms
Nocturnal Akinesia
Parasomnias
REM Sleep Behavior Disorder and Differential Diagnosis with Other Parasomnias
Excessive Daytime Somnolence and Sudden Onset of Sleep
Driving, Excessive Daytime Sleepiness, and Sudden Onset of Sleep
Restless Legs Syndrome and Periodic Limb Movements
Sleep Disordered Breathing
Nocturia
Neuropsychiatric Comorbidites Complicating Sleep in PD
Drug Induced Sleep Disruption
Diagnostic Tools for Sleep Disorders in PD
Treatment
Sleep Hygiene
Nocturia
Nocturnal Akinesia
Excessive Daytime Sleepiness
Neuropsychiatric Problems
REM Behavior Disorder
Deep Brain Stimulation
The Future
Conclusion
References
8. Neuropsychological aspects
Introduction
Role of Neuropsychology In Parkinson’s Disease
Testing Considerations
Pathophysiology of Neurobehavioral Dysfunction In Parkinson’s Disease
Neurobehavioral Profile of Parkinson’s Disease
Attention/Working Memory
Executive Functioning
Language
Visuospatial Functioning
Learning and Memory
Parkinson’s Disease Versus Lewy Body Dementia
Effects of Emotional Functioning On Cognition In Parkinson’s Disease
Depression and Apathy
Anxiety
Effects of Pharmacologic and Surgical Treatment On Cognition and Behavior In Parkinson’s Disease
Pharmacologic Treatments
Neurosurgical Interventions
Ablation
Deep Brain Stimulation
Transplantation
Neuropsychological Aspects of Parkinson-Plus Syndromes
Progressive Supranuclear Palsy
Multiple System Atrophy
Corticobasal Degeneration
References
9. Management of anxiety and depression
Introduction
Anxiety
Epidemiology
Mechanisms
Detection and Recognition
Treatment
Benzodiazepines
Selective Serotonin Reuptake Inhibitors
Miscellaneous Agents
Depression
Epidemiology
Mechanisms
Detection and Assessment
Treatment
Pharmacologic Treatment
Selective Serotonin Reuptake Inhibitors
Tricyclic Antidepressants
Miscellaneous Agents
Dopamine Agonists
Assessment of Efficacy
Nonpharmacologic Treatment
Conclusion
References
10. Management of psychosis and dementia
Introduction
Psychosis
Pathophysiology of Psychosis and Risk Factors
General Treatment of Psychosis
Specific Treatments for Psychosis
Atypical Antipsychotics
Clozapine
Risperidone
Olanzapine
Quetiapine
Ziprasidone
Aripiprazole
Odansetron
Cholinesterase Inhibitors
Pimavanserin (ACP-103)
Patterns, Trends, and Recommendations in Antipsychotic Prescribing for Parkinson’s Disease Psychosis
Electroconvulsive Therapy
Long-Term Outcome of Treatment for Psychosis
Dementia
Incidence, Prevalence, and Risk Factors
Clinical Features and Progression of PD Dementia
Pathophysiology of PD Dementia
Pathology and Imaging
Biomarkers
General Treatment of Dementia
Treatment for Dementia
Cholinesterase Inhibitors
NMDA Antagonists
Other Pharmacologic Agents
References
11. Neuroimaging
Introduction
Structural Imaging
Magnetic Resonance Imaging
Transcranial Sonography
Functional Imaging
Parkinson’s Disease
The Presynaptic Dopaminergic System
Measuring Striatal Dopamine in PD
Detection of Preclinical PD
Mechanisms Underlying Motor Complications
Monitoring PD Progression with Molecular Imaging
Nonmotor Complications of PD
Cardiac Sympathetic Function
Atypical Parkinsonian Syndromes
Multiple System Atrophy
Progressive Supranuclear Palsy
Conclusions
References
12. Neuropathology of parkinsonism
Introduction
Parkinson’s Disease
Macroscopic Findings in PD
Microscopic Findings in PD
Distribution of α-Synuclein Pathology in PD
Neuropathology of Dementia in PD
Multiple System Atrophy
Macroscopic Findings in MSA
Microscopic Findings in MSA
Progressive Supranuclear Palsy
Macroscopic Findings in PSP
Microscopic Findings in PSP
Corticobasal Degeneration
Macroscopic Findings in CBD
Microscopic Findings in CBD
Guam Parkinson–Dementia Complex
Macroscopic Findings in PDC
Microscopic Findings in PDC
Chronic Traumatic Encephalopathy
Macroscopic Findings in CTE
Microscopic Findings in CTE
Familial Parkinsonism
Acknowledgments
References
13. Neurophysiology
Overview
Introduction
The Dynamics of Lower Motor Neuron Control
Recruitment of Motor Unit Activity to Threshold for Movement
Motor Unit Recruitment Order and Rate of Change
Parallel and Distributed Control of Motor Unit Recruitment
Higher Levels of Motor Unit Control
Modulation of Ongoing Motor Unit Activity
Orchestration Among Muscles for Simple Single Joint Rotations
Orchestration Among Muscles for Complex Multijoint Rotations
Whole Body Orchestration
Integration of Multiple and Independent Dynamics
Role of The Basal Ganglia–Thalamic–Cortical System In Dynamics of Motor Unit Control
Evidence of Oscillatory Activity within the Basal Ganglia–Thalamic–Cortical System
Convergence and Divergence Between Oscillator States
Oscillator Mechanism
Anatomical Nature of The Basal Ganglia–Thalamic–Cortical Oscillators Network
Role of Inhibition and Postinhibitory Rebound Excitation
The Globus Pallidus Interna Rate Theory
The Beta Oscillation Theory
References
14. Animal models of Parkinson’s disease and related disorders
Introduction
Pharmacological/Neurotoxin-Induced Models of Parkinson’s Disease
Reserpine
Alpha-Methyl-Para-Tyrosine
Neurotoxin-Induced Models of Parkinson’s Disease
6-Hydroxydopmine
1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine
The MPTP-Lesioned Mouse Model
MPTP-Lesioned Nonhuman Primate
MPTP Lesioning in Other Species
Methamphetamine
Rotenone
Paraquat
Proteasome Inhibitors
Genetic Models of Parkinson’s Disease
Spontaneous Rodent Models For Parkinson’s Disease
Transgenic Mouse Models
α-Synuclein
Parkin
DJ-1
UCH-L1
LRRK2
PINK1
NURR1
Multiple Transgenic Mouse Models
Other Transgenic Mice
Transgenic Rat Models
Conditional Knockout and Vector Targeting
Invertebrate Genetic Models
Models of Pd Variants
Multiple System Atrophy and Striatonigral Degeneration
The Tauopathies Including Progressive Supranuclear Palsy and Other Tau-Related Disorders
Conclusions
Acknowledgments
References
15. Genetics
Introduction
Epidemiologic Studies
Studies of Twins
Evaluation of Kindreds
PD/Parkinsonism Genes/Loci with Autosomal Dominant Inheritance
PARK1: Alphα-Synuclein
PARK3: Gene Unknown
PARK5: Ubiquitin Carboxy-Terminal Hydrolase L1
PARK8: Leucine-Rich Repeat Kinase 2
PARK11: Grb10-Interacting GYF Protein 2
PARK13: Omi/High Temperature Requirement Protein A2
PARK17: Vacuolar Protein Sorting 35
PARK18: Eukaryotic Translation Initiation Factor 4-Gamma
PD/Parkinsonism Genes/Loci with Autosomal Recessive Inheritance
PARK2: Parkin
PARK6: PTEN-Induced Putative Kinase 1
PARK7: DJ-1
PARK9: ATPase Type 13A2
PARK14: Phospholipase A2, Group 6
PARK15: F-Box Only Protein 7
PD Gene Associated with X-Linked Inheritance
PARK12: Gene Unknown
PD Loci with Undetermined Mode of Inheritance
PARK10: Gene Unknown
PARK16: Gene Unknown
Genetic Variants/Susceptibility PD Genes in Mendelian Genes
LRRK2 Variants
SNCA Variants
MAPT: Microtubule-Associated Protein Tau
GBA: Glucocerebrosidase
Hereditary Parkinsonism with Non-PARK Genes/Loci
Association Studies and Genome-Wide Association Studies
Digenic Inheritance
Phenocopy
Clinical Molecular Genetic Testing
Summary
Acknowledgments
References
16. Environmental risk factors
Genes Versus Environment
Genetic and Family Studies
Geography and PD
Specific Environmental Toxins
Manganese
Lead
Pesticides/Herbicides
Carbon Disulfide
Solvents
Specific Occupations and Parkinsonism
Farming
Pesticide Applicators
Steel Industry
Welding
Conclusions
Acknowledgments
References
17. Disease modification
Introduction
The First Trials In Disease Modification: The Emergence of Selegiline
Neuroimaging As A Surrogate Biomarker
Levodopa: Toxic Or Disease Modifying
The Delayed Start Design and Rasagiline
A Road Map To The Future
Conclusion
References
18. Amantadine and anticholinergics
Introduction
Amantadine
History
Pharmacokinetics and Dosing
Clinical Uses
Early Parkinson’s Disease
Advanced Parkinson’s Disease
Miscellaneous Considerations
Side Effects
Mechanisms of Action
Summary
Anticholinergics
History
Pharmacokinetics and Dosing
Clinical Uses
Tremor-Predominant Parkinson’s Disease
Parkinson’s Disease-Associated Dystonia
Miscellaneous Considerations
Side Effects
Central Side Effects
Peripheral Side Effects
Mechanisms of Action
Summary
Conclusion
References
19. Levodopa
Introduction
Historical Overview
Pharmacology of Levodopa
Pharmacokinetics
Preparations
The Therapeutic Response of Levodopa
Efficacy and Side Effects
Response Fluctuations and Dyskinesia
Phenomenology of Motor and Nonmotor Fluctuations
Phenomenology of Dyskinesia
Prevalence and Pathopysiology of Motor Complications and Dyskinesia
Cognitive Effects and Neuropsychiatric Complications of Levodopa
Limitations of Levodopa Therapy and The Issue of Levodopa Toxicity
Practical Aspects of Levodopa Treatment
Initiating Treatment
Optimization of Levodopa Treatment In Moderate and Advanced-Stage Parkinson’s Disease
Wearing Off
Delayed on and Dose Failure
Unpredictable Motor Fluctuations
Management of Dyskinesia
Management of Psychiatric Side Effects
Recent Developments In Treatment With Levodopa
Intraduodenal Levodopa Therapy
Newer Levodopa Formulations
References
20. Dopamine agonists
Introduction
Dopamine Agonists and Dopamine Receptors
Apomorphine
Bromocriptine
Pergolide
Pramipexole
Ropinirole
Cabergoline
Rotigotine
Piribedil
Comparisons Between Dopamine Agonists
Initiation of Dopamine Agonist Therapy
Conclusions
References
21. Monoamine oxidase inhibitors
Introduction
Mechanisms of Action
Hypertensive Crisis
Neuroprotective Effects of Mao Inhibitors
Selegiline
Clinical Trials of Selegiline Datatop
Other Trials in Early PD
Advanced PD
Selegiline and Mortality
Zydis Selegiline
Rasagiline
Clinical Trials of Rasagiline Tempo
Adagio
Presto
Largo
Rasagiline Adverse Events
Conclusion
References
22. Catechol-O-methyltransferase inhibitors
First-Generation Comt Inhibitors
Second-Generation Comt Inhibitors
Nitecapone
Entacapone
Levodopa/Carbidopa/Entacapone (Stalevo)
Tolcapone
Nebicapone
Current Status of Comt Inhibitors
References
23. Investigational pharmacological treatments
Introduction
New Dopaminergic Agents
Levodopa Formulations
Levodopa Carbidopa Intestinal Gel
IPX066
XP21279
New Dopamine Agonists
Pardoprunox
Monoamine Oxidase Inhibitors
Safinamide
Adenosine A2A Receptor Antagonists
Istradefylline
Preladenant
Treatments Targeting Dyskinesia
ADS-5102
ADX48621
AFQ056
Novel Agents With Unique Mechanisms of Action
Isradipine
PYM50028
Pioglitazone
Gene Therapies
AAV2-GAD
AAV2-NTN
Treatment For Nonmotor Symptoms
Conclusion
Acknowlegments
References
24. Deep brain stimulation
History
Deep Brain Stimulation Hardware
Advantages and Disadvantages of Dbs
Deep Brain Stimulation of The Thalamus
Deep Brain Stimulation of The Globus Pallidus Interna
Deep Brain Stimulation of The Subthalamic Nucleus
Predictors of Outcome After Stn Dbs
Deep Brain Stimulation of The Globus Pallidus Interna Or The Subthalamic Nucleus?
Deep Brain Stimulation Vs Best Medical Management
Patient Selection For Pallidal and Subthalamic Deep Brain Stimulation
Adverse Effects of Dbs
Surgical Complications
Hardware-Related Complications
Stimulation Complications
Conclusions
References
25. Investigational surgical therapies
Introduction
Shortcomings of Current Surgical Therapies
New Stimulation Systems
Novel Stimulation Targets
Pedunculopontine Nucleus
Posterior Subthalamic Area
Motor Cortex Stimulation
Early Deep Brain Stimulation
Intracerebral Drug Infusion
Glial Cell Line-Derived Neurotrophic Factor
Neurturin
Fetal Transplantation
Stem Cell Therapy
Embryonic Stem Cells
Induced Pluripotent Stem Cells
Mesenchymal Stem Cells
Neuronal Stem Cells
Gene Therapy For PD
Strategies of Gene Therapy
Dopamine Synthesis Gene Therapy
Genetic Delivery of Neurotrophins
Gene Therapy to Alter Basal Ganglia Physiology
Parkin Gene Therapy
Intravenous Gene Delivery
Summary
References
26. Physical and occupational therapy
Introduction
International Classification of Functioning, Disability, Disability, and Health
Physical Therapy Domains
Gait
Balance and Falls
Transfers
Manual Activities
Physical Capacity
Occupational Therapy Domains
Restrictions in Participation
Limitations in Activities
Evidence-Based Clinical Guidelines
Referral To Physical Or Occupational Therapy
Assessment
General Treatment Considerations
Self-Management and Patient-Centeredness
Considering Fluctuations in Daily Functioning
Advising and Training Caregivers
Treatment Site
Interdisciplinary Collaboration
Specific Treatment Strategies
Cueing Strategies
Replacing Internal Control
Patient-Specific Cues
Cognitive Movement Strategies
Exercises to Increase Physical Capacity, Gait, and Balance
Optimizing Day Structure and Routine
Adjusting the Patient’s Home Environment
Illustrative Case Study
References
27. Voice, speech, and swallowing disorders
Introduction
Speech and Voice Characteristics
Perceptual and Phonetic Characteristics of Voice and Speech Disorders In PD
Acoustic Measures of Abnormal Voice and Speech In PD
Physiologic Measures of Laryngeal Dysfunction In PD
Respiratory Dysfunction In PD
Articulatory and Velopharyngeal Disorders: Acoustic and Kinematic Correlates of Articulatory Abnormalities In PD
Disordered Versus Compensated Rate of Speech In PD
Resonance Problems In PD
Sensorimotor and Perceptual Deficits Underlying Motor Dysfunction In PD
Disordered Language and Cognitive–Linguistic Functions
Swallowing Disorders
Effect of Medical Treatments For Pd On Speech and Swallowing
Deep Brain Stimulation
Transcranial and Extradural Brain Stimulation
Ablative Surgery
Pallidotomy
Thalamotomy and Subthalamotomy
Peripheral Surgery for Voice and Swallowing Problems
Collagen Augmentation of Vocal Folds for Hypophonia
Cricopharyngeal Myotomy for Swallowing
Hypotheses Regarding Neural Mechanisms Underlying Voice and Speech Disorders in PD
Scaling Movement Amplitude
Sensory Processing
Internal Cueing
Attention to Action (Vocal Vigilance)
Behavioral Speech, Voice, and Swallowing Treatment for Parkinson’s Disease
Intensive Voice Treatment for Parkinson’s Disease
Effectiveness of Lsvt Loud On Voice
Effects of Lsvt Loud On The Orofacial System
Effects of Lsvt Loud On Brain Activity
Swallowing Treatment For Parkinson’s Disease
Effects of Lsvt Loud On Facial Expression In PD
Administration of Lsvt Loud By Electronic Devices and Virtual Clinicians
Acknowledgment
References
28. Complementary and alternative medicine in Parkinson’s disease
Introduction
Definition of Complementary and Alternative Medicine
Prevalence of Complementary and Alternative Medicine Use In Parkinson’s Disease
Classification of Complementary and Alternative Medicine
Medicinal Therapies
Nutritional Therapy
Ketogenic Diets
Dietary Supplements
Ayurveda
Chinese Herbal Medicine
Green Tea and Other Plant Polyphenols
Other Herbs with Bioactive Agents in Parkinson’s Disease
Homeopathy
Manipulative and Touch Therapies
Traditional Chinese Medicine
Acupuncture
Cupping Therapy
Massage
Chiropractic
Reflexology
Aromatherapy
Reiki
People also search for Handbook of Parkinson’s Disease 5th :
parkinson’s disease handbook
handbook of parkinson’s disease fifth edition
parkinson handbook
parkinson’s disease pdf free download
parkinson’s pdf