Textbook of Neuromodulation Principles Methods and Clinical Applications 1st edition by Helena Knotkova, Dirk Rasche – Ebook PDF Instant Download/Delivery: 1493914073, 978-1493914074
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ISBN 10: 1493914073
ISBN 13: 978-1493914074
Author: Helena Knotkova, Dirk Rasche
Until recently, it was thought that the adult brain is modifiable only during early stages of ontogenesis. However, neurophysiological and neuroimaging studies now indicate that the mature human brain is, under certain conditions, capable of substantial neuroplastic changes. Neuroplasticity reflects the ability of the human brain to alter the pattern of neural activation in response to previous experience, and recent findings indicate that the effects of experience can lead to both structural as well as functional reorganization. It has been shown that pathological neuroplastic changes can be reverted/normalized and that the modulation of the neuroplastic changes can be paralleled by improvement of the patient’s status. However, there is a gap between the potential of neuromodulation, technical progress and actual preparedness of medical personnel to provide this type of treatment. A prevalent opinion among medical professionals indicates that training programs and educational materials in neuromodulatory techniques are well needed and appreciated. Neuromodulation will focus on the description and discussion of methods currently available for invasive and non-invasive neuromodulation, their clinical potential, significance and practical applications. In order to facilitate understanding of the topic, the initial part of the textbook will review neurophysiological systems involved in neuromodulation and will provide readers with basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine. Additionally, the clinical use of these techniques will be described with special regard to safety and avoidance of complications.
Textbook of Neuromodulation Principles Methods and Clinical Applications 1st Table of contents:
Part I: Basic Aspects
1: Principles of Neuromodulation
Neuroplasticity and Neuromodulation
Cortical Reorganization
References
2: Methods and Technologies for Low-Intensity Transcranial Electrical Stimulation: Waveforms, Termin
Scope and Approach
Historical Development
Developments from Electrosleep to Cranial Electrotherapy Stimulation
Developments from Electroanesthesia to Limoge Currents and Other Related Methods
Direct Current Stimulation
Electroconvulsive Therapy
Contemporary Approaches
Transcranial Alternating Current Stimulation
Noncranial Therapies
Dosage
Electrosleep and Derivative Techniques
Electroanesthesia and Derivative Techniques
Transcranial Direct Current Stimulation/Transcranial Random Noise Stimulation/Transcranial Alternati
High-Definition Transcranial Direct Current Stimulation
Transcranial Electrical Stimulation
Electroconvulsive Therapy
Conclusion
References
Part II: Methods
3: Peripheral Nerve Stimulation
Introduction
The Spectrum of Peripheral Nerve Stimulation
Transcutaneous Electrical Nerve Stimulation
Percutaneous Electrical Nerve Stimulation
Peripheral Nerve Stimulation
PNS/PNFS Techniques
Indications and Patient Selection
Neuropathic Limb Pain
Neuropathic Facial Pain
Neuropathic Trunk Pain
Peripheral Nerve Field Stimulation of the C2 Nerve
Indications for C2 PNFS
Headache
Headache: Occipital Neuralgia
Headaches: Chronic Migraine
Headaches: Cluster Headache
Fibromyalgia
Peripheral Pain
Tinnitus
Device Choice
Procedural Details
Occipital Nerve Stimulation Techniques
PNS Complications
Outcomes
Conclusions
References
4: Spinal Cord Stimulation
Introduction
Mechanisms of Action of Spinal Cord Stimulation
Local Effects at the Spinal Level
Effects at Cerebral Level
Peripheral Effects on Vasculature
Indications for Spinal Cord Stimulation
Spinal Cord Stimulation for Treatment of Peripheral Neuropathic Pain
Characterization of Neuropathic Pain
Failed Back Surgery Syndrome
Spinal Cord Stimulation for Treatment of Complex Regional Pain Syndrome
Spinal Cord Stimulation for Treatment of Painful Ischemic Disorders
Spinal Cord Stimulation Stem Components and Implantation Technique
Safety Profile of Spinal Cord Stimulation
Evidence-Based Support for Efficacy of Spinal Cord Stimulation
Cost-Effectiveness of Spinal Cord Stimulation
New Technology, Techniques, and Indications
The Future
References
5: Dorsal Root Ganglion Stimulation: A Target for Neuromodulation Therapies
Role of the Dorsal Root Ganglion in Chronic Pain
Interventional Techniques Targeting the DRG
Case 1: Neuropathic Groin Pain
Case 2: Postamputation Pain
Case 3: Complex Regional Pain Syndrome
Case 4: Failed Back Surgery Syndrome
Conclusions
References
6: Deep Brain Stimulation
Introduction
Mechanism of Action
Stimulation of the Lateral Somatosensory Thalamus
Stimulation of the Periventricular or Periaqueductal Grey
Stimulation of CM-PF Thalamic Nuclei
Stimulation of the Posteromedial Hypothalamus
Operative Technique
Step 1: Preoperative Imaging (Without Frame)
Step 2: Stereotactic Frame Placement
Step 3: Magnetic Resonance Imaging with Frame
Step 4: Presurgical Target Planning
Step 5: Presurgical Trajectory Planning
Step 6: Prepare the Patient for the OR
Step 7: Stereotactic Arc Fixation
Step 8: Incision and Making the Burrhole
Step 9: Attachment of Lead Fixation Device on Burrhole
Step 10: Stereotactic Arc Fixation
Step 11: Physiological Confirmation of Anatomical Target
Step 12: Intraoperative Testing with Microelectrode Recording System
Step 13: DBS Lead Placement
Step 14: Intraoperative Clinical Testing with DBS Lead
Step 15: DBS Lead Fixation
Step 16: Intraoperative Final Lead Confirmation
Step 17: Dismantle Equipment and Suturing Incision
Step 18: Postoperative Final Lead Confirmation
Step 19: IPG Placement
Clinical Results
Conclusion
References
7: Motor Cortex Stimulation
Introduction and History of Invasive Cortical Stimulation
Mode of Action
Patient Selection
Perioperative Management
Operative Procedure
Post-operative Test Trial
Follow-Up Visits
Complications
Discussion and Review of the Literature
MCS in the Treatment of Chronic Pain
ICS in the Treatment of Non-painful Conditions/Syndromes
Parkinson´s Disease and Movement Disorders
Depression
Tinnitus
Stroke
Epilepsy
Conclusion
References
8: Physiological Basis of Transcranial Magnetic Stimulation
Introduction
History of Motor Cortical Stimulation
Neuronal Elements Activated by TMS
TMS Methodology and Measurements
Coil Types
Circular Coil
Figure-of-Eight Coil
Double Cone Coil
Batwing Coil
TMS Coil Orientations
PA Orientation
LM Orientation
AP Orientation
Neurophysiological Measurements Examined by TMS
SICI
IHI
Therapeutic Uses of TMS: Repetitive TMS
Conclusions
References
9: Transcranial Direct Current Stimulation: Protocols and Physiological Mechanisms of Action
Introduction
tDCS Protocols
Impact of Stimulation Polarity/Electrode Position on the Effects of tDCS
Impact of Current Density on the Effects of tDCS
Impact of Stimulation Duration on the Effects of tDCS
Impact of Electrode Configurations on the Focality of tDCS
Mechanisms of Action of tDCS
Regional Effects of tDCS on Cortical Excitability
Acute Effects of tDCS on Cortical Activity and Excitability
Aftereffects of tDCS on Cortical Activity, and Excitability
Interregional Effects of tDCS: Impact on Functional Connectivity
Conclusion
References
10: A Role of Computational Modeling in Customization of Transcranial Direct Current Stimulation for
Introduction to Computational Models of Noninvasive Neuromodulation
Methods and Protocols in the Generation of Computational Forward Models of tDCS
Pitfalls and Challenges in the Application and Interpretation of Computational Model Predictions
Example Results of Computational Analysis in Susceptible Populations
Case 1: Skull Defects
Case 2: Brain Lesions (Stroke)
Case 3: Pediatric Populations
Case 4: Obesity
Case 5: Skin Properties
Conclusion
References
11: Cranial Electrical Stimulation
Introduction
Contemporary Devices and Clinical Applications
Evidence of CES Efficacy from Open and Randomized Clinical Trials
Contraindications for Use and Safety of CES
CES Regulatory Status (FDA)
Proposed Mechanisms of Action of CES
Brain Structures Impacted by CES
Evidence for Effects on Endogenous Brain Oscillations and Cortical Excitability
Evidence for Impact on Neurotransmitters, Hormones, and Endorphins
Evidence for Impact on Autonomic Nervous System
CES and Alternative Medicine
Barriers and Future Directions
Conclusion
References
12: The Mechanisms and Actions of Motor Imagery Within the Clinical Setting
What Is Motor Imagery?
Neurophysiology of Movement Initiation
Primary Motor Cortex
Premotor Cortex
Supplementary Motor Areas
Motor Imagery and Movement
Clinical Application of Motor Imagery (See Table12.1 for Summary of Studies)
Graded Motor Imagery
Outcome Measures in Motor Imagery
Questionnaires
Mental Chronometry
Mental Rotation
Conclusion
References
Recommended Reading
13: Neuroprosthesis and Sensorimotor Training
Introduction
Brain Changes in Chronic Pain
Injury-Related Brain Changes in Neuropathic Pain Disorders
Brain Changes in Musculoskeletal Pain Disorders
Interventions
Sensory and Motor Training
Mirror and Motor Imagery Training
Virtual Reality Approaches to Mirror Training and Robotic Applications
Conclusions
References
Part III: Clinical Potential and Applications
14: Clinical Applications of Neuromodulation in Psychiatry
Major Depressive Disorder
Pharmacotherapy
Neuromodulation Strategies
Electroconvulsive Therapy
Repetitive Transcranial Magnetic Stimulation (rTMS)
Transcranial Direct Current Stimulation
Deep Brain Stimulation (DBS)
Cranial Nerve Stimulation
Bipolar Disorder
Pharmacotherapy
Electroconvulsive Therapy
Repetitive Transcranial Magnetic Stimulation (rTMS)
Transcranial Direct Current Stimulation
Schizophrenia
Pharmacological Treatment for Schizophrenia
Electroconvulsive Therapy
Repetitive Transcranial Magnetic Stimulation
Transcranial Direct Current Stimulation
Eating Disorders
Pharmacotherapy
Neuromodulation Strategies
Obsessive Compulsive Disorder (OCD)
Pharmacotherapy
Cognitive-Behavioral Therapy
Transcranial Magnetic Stimulation
Attention Deficit Hyperactivity Disorder (ADHD)
Pharmacotherapy
Neuromodulation Strategies
Conclusion
References
15: Applications of Neuromodulation in Pain Management
Complex Regional Pain Syndrome (CRPS)
Treatment Strategies in CRPS
Neuromodulation
Repetitive Transcranial Magnetic Stimulation (rTMS)
Transcranial Direct Current Stimulation (tDCS)
Motor Imagery
Motor Cortex Stimulation (MCS)
Spinal Cord Stimulation (SCS)
Phantom-Limb Pain
Treatment Strategies in PLP
Neuromodulation
rTMS
Visual Feedback Therapy and Motor Imagery
MCS and DBS
SCS
Central Post-stroke Pain (CPSP)
Treatment Strategies in CPSP
Neuromodulation
rTMS
DBS
MCS
SCS
Facial Neuropathic Pain
Treatment Strategies in Facial Neuropathic Pain
Neuromodulation
rTMS and tDCS
DBS
MCS
Fibromyalgia
Treatment Strategies in Fibromyalgia
Neuromodulation
rTMS
tDCS
Cranial Electrotherapy Stimulation (CES)
ECT
Headaches
Treatment Approaches to Migraine and Cluster Headache
Neuromodulation
rTMS
tDCS
DBS
Occipital Nerve Stimulation (ONS)
SCS
Ganglion Sphenopalatinum Stimulation
Other Chronic Pain Syndromes
Post-herpetic Neuralgia
Low-Back Pain
Conclusions
References
16: Applications of Neuromodulation in Neurology and Neurorehabilitation
Movement Disorders
Parkinson´s Disease
Pharmacologic Treatment in PD
Non-pharmacologic Management of PD
Rehabilitation in PD
Neuromodulatory Approaches for the PD
Electroconvulsive Therapy (ECT)
Repetitive Transcranial Magnetic Stimulation (rTMS)
Transcranial Direct Current Stimulation (tDCS)
Deep Brain Stimulation (DBS)
Dystonia
Dopamine Therapy
Antidopaminergic Therapy
Anticholinergic Therapy
Anticonvulsants
Other Pharmacologic Agents
Botulinum Toxin
Surgical Procedures Except DBS
Neuromodulatory Approaches for Dystonia
Repetitive Transcranial Magnetic Stimulation (rTMS)
Transcranial Direct Current Stimulation (tDCS)
Deep Brain Stimulation (DBS)
Essential Tremor
Beta Blockers
Anticonvulsants
Benzodiazepines
Botulinum Toxin
Neuromodulatory Approaches for ET
Electroconvulsive Therapy
Repetitive Transcranial Magnetic Stimulation (rTMS)
Deep Brain Stimulation (DBS)
Tics or Tourette´s Syndrome
Dopamine Antagonists
Dopamine Agonists
Other Drugs
Botulinum Toxin Injection
Neuromodulatory Approaches for Tics and Tourette´s Syndrome
Electroconvulsive Therapy (ECT)
Repetitive Transcranial Magnetic Stimulation (rTMS)
Deep Brain Stimulation (DBS)
Chorea
Neuromodulatory Approaches for Chorea
Electroconvulsive Therapy
Repetitive Transcranial Magnetic Stimulation (rTMS)
Deep Brain Stimulation (DBS)
Neurodegenerative Disorders
Alzheimer´s Disease
Pharmacologic Treatment
Acetylcholinesterase Inhibitors
Neuromodulatory Approaches for the AD
Electroconvulsive Therapy (ECT)
Repetitive Transcranial Magnetic Stimulation (rTMS)
Transcranial Direct Current Stimulation (tDCS)
Deep Brain Stimulation (DBS)
Neurodegenerative Disorder Associated With Human Immunodeficiency Virus (HIV) Infection
Conventional Treatment in HIV
Zidovudine
Antiretroviral Agents
Immune-Based and Neuroprotective Therapies
Neuromodulatory Approaches for the HIV
Post-stroke Rehabilitation
Motor Recovery
Visuospatial Neglect
Aphasia
Dysphagia
Cognitive Decline
Post-amputation Rehabilitation
Neuromodulatory Approaches for the Amputation
Conclusion
References
17: Neuromodulation for Addiction
Introduction
Epidemiological Significance
Neurobiology of Reward and Addiction
Effects of Therapeutic Neurosurgical Lesions on Addictive Behavior
Noninvasive Neuromodulatory Techniques and Addiction
The Scientific Rationale Behind Deep Brain Stimulation for Treating Addiction
DBS to Treat Addictive Patterns in Animal Models
Cocaine
Ethyl Alcohol
Opioids
DBS for Influencing Substance Dependencies in Humans
Hypotheses Pertinent to the Effects of DBS on Addiction, viz. Substance Addiction
Conclusion
References
18: Enhancement of Sensory and Cognitive Functions in Healthy Subjects
Introduction
Transcranial Magnetic Stimulation (TMS)
TMS: Modes of Operation
TMS Protocols
TMS and Cognitive Enhancement
TMS: Major Caveats
Electrical Brain Stimulation: tDCS
Enhancing Language with tDCS
Neural Underpinning of DC Effects
Enhancing Cognitive Control With tDCS
Enhancing Other PFC-Related Functions
Enhancing Learning and Memory with tDCS
tACS: Harnessing Oscillatory Brain Activity to Explore and Improve Sensory and Cognitive Functions
Discussion
Enhancing Cognitive Functions: Methodological Considerations
Future Direction: tDCS Use in Clinical Contexts and Combining With Training
References
19: Conclusive Overview
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