Microfluidic Cell Culture Systems 1st edition by Jeffrey Borenstein, Vishal Tandon, Sarah Tao, Joseph Charest 0128136715 978-0128136713

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ISBN-10 ‏ : ‎ 0128136715

ISBN-13 ‏ : ‎ 978-0128136713

Author: Jeffrey T. Borenstein, Vishal Tandon, Sarah L. Tao, Joseph L. Charest

Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems.

This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems.

 

Microfluidic Cell Culture Systems 1st Table of contents:

Chapter 1 – Design principles for dynamic microphysiological systems

Chapter 2 – Microfluidic systems for controlling stem cell microenvironments

Chapter 3 – Microfluidic platforms with nanoscale features

Chapter 4 – Microfabricated kidney tissue models

Chapter 5 – Application of complex in vitro models (CIVMs) in drug discovery for safety testing and disease modeling

Chapter 6 – Hepatic microphysiological systems: Current and future applications in drug discovery and development

Chapter 7 – Microphysiological models of human organs: A case study on microengineered lung-on-a-chip systems

Chapter 8 – Cardiac tissue models

Chapter 9 – Neural tissue microphysiological systems in the era of patient-derived pluripotent stem cells

Chapter 10 – A high-throughput system to probe and direct biological functions driven by complex hemodynamic environments

Chapter 11 – Body-on-a-chip systems: Design, fabrication, and applications

Chapter 12 – On-chip disease models of the human retina

 

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