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Cancer Systems Biology 1st Edition by Edwin Wang ISBN 1138113298 9781138113299

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ISBN 10:    1138113298
ISBN 13: 978-1138113299
Author:       Edwin Wang

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorgenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and their applications in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.

Cancer Systems Biology 1st  Table of contents:

Section I. Cancer Systems Biology: Concepts and Applications

Chapter 1. A Roadmap of Cancer Systems Biology

Chapter 2. Network Biology, the Framework of Systems Biology

Chapter 3. Reconstructing Gene Networks Using Gene Expression Profiles

Chapter 4. Understanding Cancer Progression in Protein Interaction Networks

Chapter 5. From Tumor Genome Sequencing to Cancer Signaling Maps

Chapter 6. Ubiquitin-Mediated Regulation of Human Signaling Networks inNormal and Cancer Cells

Chapter 7. microRNA Regulation of Networks of Normal and Cancer Cells

Chapter 8. Network Model of Survival Signaling inT-Cell Large Granular Lymphocyte Leukemia

Chapter 9. Cancer Metabolic Networks

Chapter 10. Warburg Revisited

Chapter 11. Cancer Gene Prediction Using a Network Approach

Section II. Cancer Biology: Basic Concepts and Cutting-Edge Topics

Chapter 12. Cancer Genomics to Cancer Biology

Chapter 13. Epithelial-to-Mesenchymal Transition (EMT)

Chapter 14. Tumors and Their Microenvironments

Chapter 15. Tumor Angiogenesis

Section III. Data Resources and Software Tools for Cancer Systems Biology

Chapter 16. Modeling Tools for Cancer Systems Biology

Chapter 17. Advanced Visualization, Analysis, and Inference of Biological Networks Using VisANT

Chapter 18. Gene Set and Pathway-Based Analysis for Cancer Omics

Chapter 19. SH2 Domain Signaling Network and Cancer

Chapter 20. Data Sources and Computational Tools for Cancer Systems Biology

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