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MacSween’s Pathology of the Liver 7th edition by Alastair Burt, Linda Ferrell, Stefan Hubscher ISBN 0702066974 970702066979

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MacSween’s Pathology of the Liver 7th edition by Alastair D. Burt, Linda D. Ferrell, Stefan G. Hübscher  – Ebook PDF Instant Download/Delivery: 0702066974, 978-0702066979
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ISBN 10:     0702066974
ISBN 13: 978-0702066979
Author:      Alastair D. Burt, Linda D. Ferrell, Stefan G. Hübscher  

Since its first publication more than 35 years ago, MacSween’s Pathology of the Liver, by Drs. Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher, has established itself as the definitive reference on liver pathology. The 7th Edition continues the tradition of excellence with more than 1,000 high-quality illustrations, coverage of the new and emerging diagnostic applications and techniques that pathologists must be familiar with, an up-to-date review of drug-induced injury, and much more. A must-have for every surgical pathologist, MacSween’s remains the most authoritative and comprehensive book in its field.

  • Provides comprehensive, state-of-the-art coverage of all malignant and benign hepatobiliary disorders from an international “who’s who” in the field.
  • Helps you quickly recognize the wide variety of liver appearances that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins.
  • Features 1,000+ full-color illustrations that provide a complete visual guide to each tumor or tumor-like lesion and assist in the recognition and diagnosis of any tissue sample you’re likely to encounter.
  • Incorporates relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools required to master the latest breakthroughs in diagnostic technology.
  • Includes an updated chapter on mechanisms of liver disease, including coverage of regression and remodeling of disease and new information on next generation sequencing; an up-to-date review of drug-induced injury, including the effects of herbal and alternative medicines.
  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

MacSween’s Pathology of the Liver 7th Table of contents:

1. Structure, Function, and Responses to Injury

  • Development of the liver
  • Macroanatomy of the liver
  • Microanatomy of the liver
  • General concepts of liver injury and repair
  • Hepatocellular injury
  • Cell death
  • Regeneration
  • Fibrosis
  • Vascular remodelling
  • Evolution of chronic liver diseases
  • The liver in biopsy and autopsy specimens
  • References

2. Cellular and Molecular Techniques

  • Liver biopsy
  • Routine handling, fixation and staining of liver specimens
  • Immunohistochemistry
  • Molecular techniques
  • Other microscopic and optical techniques
  • References

3. Developmental and Inherited Liver Disease

  • Diagnostic approach to histology
  • Neonatal hepatitis
  • Biliary atresia
  • Paucity of intrahepatic bile ducts
  • Bile duct anomalies, congenital dilations and ductal plate malformation disorders
  • Cystic fibrosis
  • Hereditary disorders of bile acid synthesis and bilirubin metabolism
  • Disorders of porphyrin metabolism
  • Disorders of carbohydrate metabolism and related conditions
  • Disorders of glycoprotein and glycolipid metabolism
  • Endoplasmic reticulum storage diseases
  • Disorders of amino acid metabolism
  • Disorders of lipoprotein and lipid metabolism
  • Peroxisomal disorders
  • Mitochondrial cytopathies and related conditions
  • Disorders of copper metabolism
  • Primary immunodeficiencies
  • Histiocytic and haemophagocytic syndromes
  • Miscellaneous disorders
  • Anatomical anomalies
  • References

4. Disorders of Iron Overload

  • Iron metabolism and homeostasis
  • Hereditary iron overload
  • Miscellaneous iron overload
  • Acquired and secondary iron overload
  • Role of liver biopsy in iron overload
  • References

5. Fatty Liver Disease

  • Spectrum of fatty liver disease
  • Alcoholic liver disease
  • Pathology of alcoholic liver disease
  • Diagnosis and prognosis of ALD: role of liver biopsy
  • Treatment of ALD and histopathological features of resolution
  • Nonalcoholic fatty liver disease
  • Pathology of nonalcoholic fatty liver disease
  • Differential diagnosis of NAFLD
  • NAFL and NASH concurrent with other liver disease
  • Histopathological features of prognostic significance
  • NAFL and NASH in other clinical settings
  • Treatment of NAFLD
  • References

6. Viral Hepatitis

  • Acute viral hepatitis
  • Chronic viral hepatitis
  • Individual types of viral hepatitis
  • References

7. Non-Hepatotropic Viral, Bacterial, and Parasitic Infections of the Liver

  • RNA viral infections
  • DNA viral infections
  • Rickettsial and chlamydial infections
  • Bacterial infections
  • Mycobacterial infections
  • Mycotic infections
  • Protozoal infections
  • Helminth infections
  • HIV infection and AIDS
  • References

8. Autoimmune Hepatitis

  • Definition
  • Epidemiology
  • Demographic features
  • Pathogenesis
  • Clinical features
  • Diagnosis
  • Classification
  • Histopathology
  • Variant forms and cholestatic liver disease
  • Diagnostic difficulties
  • Treatment
  • Role of liver biopsy
  • References

9. Bile Duct Diseases

  • Normal morphology of biliary tree and peribiliary glands
  • Biliary epithelial injury
  • Cholangiopathy and cholangitis
  • Pathological features secondary to impaired bile flow
  • Diseases primarily affecting intrahepatic bile ducts
  • Diseases affecting extrahepatic and intrahepatic biliary tree
  • Pathology of the peribiliary glands
  • Diseases primarily affecting extrahepatic bile ducts
  • References

10. Diseases of the Gallbladder

  • Normal gallbladder
  • Routine specimen processing
  • Congenital anomalies
  • Gallstones
  • Cholecystitis
  • Other inflammatory diseases of the gallbladder
  • Diverticular disease
  • Ischaemia and infarction
  • Non-neoplastic mucosal alterations
  • Non-neoplastic tumour-like lesions
  • Preinvasive epithelial neoplasia (dysplasia)
  • Malignant neoplasms
  • Acknowledgment
  • References

11. Vascular Disorders

  • Portal vein lesions
  • Hepatic artery-related lesions
  • Sinusoidal lesions
  • Hepatic vein lesions
  • Paediatric and developmental vascular lesions
  • Nodular hyperplastic lesions
  • Vascular lesions in cirrhosis
  • References

12. Drugs and Toxins

  • Importance of drug-induced hepatic injury
  • Clinicopathological-mechanistic classification of hepatotoxic agents
  • Morphological patterns of toxic hepatic injury
  • Clinical presentation and outcome
  • Chemicals and environmental agents causing hepatic injury
  • Hepatotoxic herbal remedies, dietary supplements and weight loss products
  • Liver disease caused by medicinal agents
  • Diagnostic considerations in causality assessment of drug-induced liver injury
  • Treatment and prevention of drug-induced liver injury
  • References

13. Tumours and Tumour-like Lesions of the Liver

  • Diagnostic approach: morphological patterns
  • Benign hepatocellular tumours and tumour-like lesions
  • Malignant hepatocellular tumours and precursor lesions
  • Biliary tumours and tumour-like lesions
  • Vascular tumours
  • Nonvascular mesenchymal tumours and tumour-like lesions
  • Other tumours and tumour-like lesions
  • Leukaemia and myoproliferative disease
  • Lymphomas and lymphoreticular neoplasms
  • Metastatic tumours
  • References

14. Transplantation Pathology

  • General aspects of liver transplantation
  • Examination of native hepatectomy specimens
  • Pathological changes in post-reperfusion biopsies of donor liver and preservation/reperfusion injury
  • Liver allograft rejection
  • Infections
  • Vascular problems
  • Biliary complications
  • Disease recurrence
  • De novo disease
  • Other histological findings in post-transplant biopsies
  • Drug toxicity in liver allograft recipients
  • Liver disease after haematopoietic cell (bone marrow and peripheral stem cell) transplantation
  • References

15. The Liver in Systemic Disease

  • Nonspecific reactive hepatitis
  • Space-occupying lesions in the liver
  • Hepatic granulomas

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