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ISBN 10: 0133463583
ISBN 13: 9780133463583
Author: Margaret Schenkman, James Bowman, Robyn Gisbert, Russell BButler
Clinical Neuroscience for Rehabilitation
Clinical Neuroscience for Rehabilitation 1st Table of contents:
Part I Fundamentals: The Relationships and Development of Structures and the Basis of Their Communication
- Basic Design and Development of the Nervous System
Learning Outcomes
Acronyms
Introduction
Basic Design of The Adult Nervous System
Cells of the Nervous System
Divisions of the Nervous System
Central and Peripheral Nervous System
Somatic and Autonomic Nervous System
Organizing Principles
Regions
Directions and Planes
Ventricles, Gray Matter, and White Matter
Ventricles
Gray Matter Names
White Matter Names
Development
Morphogenesis
Gastrulation and Neurulation
Vesiculation
Brain Flexures
Ventricular System
Regional Development of the Nervous System
Alar and Basal Plates
Spinal Cord
Medulla
Pons
Cerebellum
Mesencephalon
Diencephalon
Telencephalon
Somites: Development of Vertebrae
Clinical Connections
Neural Tube Defects
Spina Bifida
Arnold-Chiari Malformation
Anencephaly
Summary
Applications
References
- Regional Anatomy and Blood Supply
Learning Outcomes
Acronyms
Introduction
Spinal Cord
Surface Features
Spinal Cord Segments and Enlargements
Segmental Innervation: Dermatomes and Myotomes
Internal Organization
Gray Matter
White Matter
Commissures
Level Variation in Cord Structure
Clinical Connections
Relationship of Symptoms to Lesions within the Pyramidal Tract
Brainstem
Surface Features
Medulla and Pons: Anterior Aspect
Medulla and Pons: Posterior Aspect
Midbrain: Anterior and Posterior Aspects
Internal Organization
Cerebellum
Cerebrum
Surface Features
Lobes of the Cerebral Hemisphere
Diencephalon
Internal Organization
Ventricular System
White Matter and the Basal Ganglia
White Matter of the Cerebral Hemisphere
Basal Ganglia
Centrals and Cs
Clinical Connections
Association Neurons of the Cortex and Language Deficits
Blood Supply of the CNS
Summary
Applications
References
- Cells of the Nervous System
Learning Outcomes
Acronyms
Introduction
Neurons
Properties Associated with Neurons
The Plasma Membrane
Classification of Neurons
Parts of the Neuron Defined According to Function
Soma (Cell Body)
Axon
Dendrites
Nerve Terminals
Organelles
Axoplasmic Transport and Axoplasmic Flow
Clinical Connections
Peripheral Nerve Regeneration
Retrograde Axonal Transport and Nervous System Pathology
Neuroglia
Astrocytes
Oligodendrocytes
Microglia
Ependymal Cells
Schwann Cells and Satellite Cells
Clinical Connections
Summary
Applications
References
- Cellular Neurobiology
Learning Outcomes
Acronyms
Introduction
Ion Channels and Electrical Activity in Neurons
The Resting Membrane Potential
Factors That Determine Flow of Current across the Membrane
Membrane Potential
Electrical Signals of Neurons
Receptor (Generator) Potential
Action Potential
Propagation of the Action Potential
Myelin and Conduction in Myelinated Axons
Postsynaptic Potentials
Clinical Connections
Multiple Sclerosis
Synapses and Synaptic Transmission
The Synapse
The Presynaptic Neuron
The Postsynaptic Neuron
Chemical Synaptic Transmission
Synthesis
Storage
Release
Transmitter-Receptor Interaction
Transmitter-Gated Ion Channels
Glutamate-Gated Channels
GABA-Gated and Glycine-Gated Channels
G-Protein-Coupled Receptors and Effector Systems
Direct Modulation of Ion Channels by G-Proteins
Second-Messenger Cascades
Postsynaptic Responses Involving Gene Expression
Inactivation
Gap Junctions and Electrical Synapses
Clinical Connections
Parkinson’s Disease
Biologic Depression
Charcot-Marie-Tooth Disorder
Phenylketoneuria
Therapeutic Drugs Affecting Transmitter Inactivation
Synaptic Plasticity
Summary
Applications
References
Part II Anatomy of the Major Regions of the Central Nervous System and Their Blood Supply
- Spinal Cord and Brainstem
Learning Outcomes
Acronyms
Introduction
Spinal Cord
Meninges of the Spinal Cord
Dura Mater
Pia Mater
Arachnoid Mater
Nuclei of the Spinal Gray Matter and Rexed’s Lamina
Nuclei
Rexed’s Laminae
Fiber Tracts of the Spinal Cord
Spinospinal (Propriospinal) System
Dorsal Columns
Spinothalamic Tract
Spinocerebellar Tracts
Lateral Corticospinal (Pyramidal) Tract
Blood Supply of the Spinal Cord
Posterior Spinal Arteries
Anterior Spinal Artery
Spinal Veins
Spinal Cord–Vertebrae Relations
Vertebral Canal and Intervertebral Foramina
Position of the Spinal Cord within the Vertebral Column
The Vertebral Column and Intervertebral Discs
Spinal Cord Segments and Their Relation to Adjacent Vertebrae
Clinical Connections
Vascular Disorders of the Spinal Cord
Extrinsic–Intrinsic Spinal Cord Lesions
Herniation of the Vertebral Disc
Vertebral Fractures and Their Consequences for the Spinal Cord
Cervical Spondylosis
Brainstem
Cross-Section Correlations: Recognizing Level
Reticular Formation
Anatomicofunctional Zones
Connections of the Reticular Formation
Afferent Projections
Efferent Projections
Functions of the Reticular Formation
Clinical Connections
Control of the Level of Consciousness
Summary
Applications
References
- Diencephalon and Cerebellum
Learning Outcomes
Acronyms
Introduction
Diencephalon
Epithalamus
Thalamus
Topographical Organization
General Functional Organization
Functions of the Thalamus
Blood Supply
Hypothalamus
Subdivisions and Nuclei of the Hypothalamus
Input to the Hypothalamus
Output from the Hypothalamus
Structural Links to the Pituitary Gland
Blood Supply
Functions of the Hypothalamus
Subthalamus
Blood Supply
Clinical Connections
Thalamic Syndrome
Hypothalamic Syndromes
Cerebellum
Clinical Connections
Summary
Applications
References
- Cerebral Hemispheres and Vascular Supply
Learning Outcomes
Acronyms
Introduction
Cerebral Cortex
Gyri and Sulci of the Cerebral Cortex
Lateral Hemispheral Surface
Medial Hemispheral Surface
Inferior Hemispheral Surface
Further Organization of the Cortex
Layers of the Cerebral Cortex
Cells and Layers of the Neocortex
Cortical Columns
Brodmann’s Map
Functional Areas
Basal Ganglia
Gross Anatomy
General Anatomy of Circuits through the Basal Ganglia
Clinical Connections
Involuntary Movements Attributed to Basal Ganglia Dysfunction
Internal Capsule
Blood Supply of The Cerebral Hemisphere
Middle Cerebral Artery
Cortical Branches
Penetrating Branches
Anterior Cerebral Artery
Cortical Branches
Penetrating Branches
Internal Carotid Artery
Posterior Cerebral Artery
Cortical Branches
Penetrating Branches
Blood Supply of the Internal Capsule and Basal Ganglia
Internal Capsule
Basal Ganglia
Clinical Connections
Middle Cerebral Artery
Anterior Cerebral Artery
Internal Carotid Artery
Posterior Cerebral Artery
Summary
Applications
References
Part III Somatosensory and Motor Systems for the Extremities and Trunk
- Introduction to the Somatic Sensory and Motor Systems
Learning Outcomes
Acronyms
Introduction
Somatosensory Systems
General Anatomical Plan
Receptors
Primary Afferent Neurons
Prethalamic Relay
Decussations
Thalamic Relay
Cerebral Cortex
Topographic Organization
Other Connections of Sensory Pathways
General Functional Plan
Parallel Processing
Efferent Modulation
Somatic Motor Systems
General Anatomical Plan and Definitions
Upper Motor Neurons
Decussations and Laterality
Synapse on Lower Motor Neurons
Efferent Fibers
Neuromuscular Junction
Modulation of Upper Motor Neuron Systems
Topographic Organization
General Functional Plan
Parallel Operation and Locus of Control
Feedback and Feedforward Control Systems
Reciprocal Innervation
Synergistic Movements
Pattern Generator–Dependent Movements
Types of Motor Activity in Functional Movement
Background Muscular Activity (Tonus)
Types of Movement from Reflexive to Voluntary
Reflexes
Voluntary Movements
Clinical Connections
Summary
Applications
References
- The Somatosensory System for the Extremities and Trunk
Learning Outcomes
Acronyms
Introduction
Somatic Receptors
General Patterns of Organization
The Classification of Receptors
Classification by Structure
Classification by the Source of the Stimulus and Location of the Receptor
Classification by the Type of Stimulus Energy That Most Readily Excites the Receptor
Classification by the Rate of Adaptation
The Receptive Field
Specific Somatosensory Receptors
Pain and Thermal Receptors
Mechanoreceptors in the Skin and Subcutaneous Tissues
Mechanoreceptors in Deep Tissues: Proprioceptors
Mechanoreceptors in Joints
Function
Peripheral Receptor Information: Uses and Actions in the CNS
Information Coding in the Receptor and Its Axon
Cutaneous Receptive Fields
Point Localization and Two-Point Discrimination
Clinical Connections
Pressure and Vibration Sensitivity
Anatomical and Functional Organization of Somatic Sensory Pathways
Somatic Afferent Pathways
First-Order Neuron
Second-Order Neuron
Third-Order Neuron
Central Processing Centers
Generalized Processing of Somatic Sensory Information
Organization of Sensory Processing
Somatic Sensory Pathways for the Head
Trigeminal Nerve
Somatic Sensory Pathways for the Body
Posterior Column–Medial Lemniscal System
Anterolateral System
Clinical Connections
Lesions of the Sensory Pathways
Summary
Applications
References
- The Motor System for the Extremities and Trunk
Learning Outcomes
Acronyms
Introduction
Motor Pathways
General Plan of the Motor System
Upper Motor Neurons
Upper Motor Neurons of the Brain
Primary Motor Cortex
Premotor Area
Supplementary Motor Area
Precentral Gyrus
Corticospinal Tract
Anterior Corticospinal Tract
Lateral Corticospinal Tract
Crossing of the Motor Pathways
Lower Motor Neurons
Motor Units
Neuromuscular Junction
Reflexes
Spinal Reflexes
Monosynaptic Reflexes
Polysynaptic Reflexes
Central Pattern Generators
Voluntary Movement Control
Cerebellum and Basal Ganglia in Movement Control
Cerebellum
Basal Ganglia
Modulation of Voluntary Movement
Clinical Connections
Lesions of Upper Motor Neurons
Lesions of Lower Motor Neurons
Motor Pathway Dysfunction
Summary
Applications
References
- The Visual System
Learning Outcomes
Acronyms
Introduction
Anatomy of the Eye
Cornea
Pupil and Iris
Lens
Retina
Structure of the Retina
Retinal Cells
Retinal Pathways
Optic Nerve
Optic Chiasm
Optic Tract
Lateral Geniculate Nucleus
Optic Radiations
Primary Visual Cortex
Visual Association Areas
Visual Pathways
Visual Fields
Visual Perception
Color Vision
Depth Perception
Clinical Connections
Lesions in the Visual Pathway
Blindness
Hemianopia
Summary
Applications
References
- The Auditory System
Learning Outcomes
Acronyms
Introduction
Anatomy of the Ear
Outer Ear
Middle Ear
Inner Ear
Hair Cells and the Cochlea
Vestibular System
Central Auditory Pathways
Auditory Pathway
Cochlear Nerve
Brainstem Auditory Nuclei
Auditory Cortex
Tonotopic Organization
Binaural Cues
Auditory Localization
Auditory Perception
Clinical Connections
Lesions of the Auditory Pathway
Summary
Applications
References
Part IV Somatosensory and Motor Systems of the Head and Neck
-
Brainstem I: Cranial Nerves Learning Outcomes
Acronyms
Introduction
Overview of the Cranial Nerves
Olfactory Nerve (I)
Clinical Connections
Clinical Evaluation of the Olfactory Nerve
Olfaction, Emotion, and Memory
Anosmia
Optic Nerve (II)
Cranial Nerves Innervating The Extraocular Muscles
Oculomotor Nerve (III)
Trochlear Nerve (IV)
Abducens Nerve (VI)
Combined Actions of Cranial Nerves III, IV, and VI
Clinical Connections
Clinical Evaluation of Eye Movement
Disorders of Eye Movements
Lesions of Cranial Nerves III, IV, and VI
Trigeminal Nerve (V)
Clinical Connections
Clinical Evaluation of the Trigeminal Nerve
Lesions of the Trigeminal Nerve
Facial Nerve (VII)
Clinical Connections
Clinical Evaluation of the Facial Nerve
Lesions of the Facial Nerve
Vestibulocochlear Nerve (VIII)
Glossopharyngeal Nerve (IX)
Clinical Connections
Clinical Evaluation of the Glossopharyngeal Nerve
Lesions of the Glossopharyngeal Nerve
Vagus Nerve (X)
Clinical Connections
Clinical Evaluation of the Vagus Nerve
Lesions of the Vagus Nerve
Accessory Nerve (XI)
Clinical Connections
Clinical Evaluation of the Accessory Nerve
Lesions of the Accessory Nerve
Hypoglossal Nerve (XII)
Clinical Connections
Clinical Evaluation of the Hypoglossal Nerve
Lesions of the Hypoglossal Nerve
Summary of The Clinical Examination of The Cranial Nerves
Summary
Applications
References -
Brainstem II: Systems and Pathways Learning Outcomes
Acronyms
Introduction
Somatosensory Systems For The Head and Neck
The Trigeminal Nerve and Associated Receptors
Second-Order Neurons
Trigeminal Lemniscus for Fine Touch and Dental Pressure
Trigeminal Thalamic Tract for Pain and Temperature as Well as Crude Touch
Third-Order Neurons of the Trigeminal System
Functions of the Trigeminal System
Clinical Connections
Somatic Motor Systems of the Head and Neck
Brainstem Reflexes
Jaw-Jerk Reflex
The Blink and Corneal Reflexes
Blink Reflex
Corneal Reflex
Stapedius Reflex
Swallowing Reflex
Corticobulbar Tract
Clinical Connections
Dysarthria
Progressive Bulbar Palsy
Pseudobulbar Palsy
Conditions Affecting the Blink Reflex
Reticular Formation
Anatomical Characteristics of Reticular Formation Neurons
Functional Characteristics of Reticular Formation Neurons
Functions of the Reticular Formation
Control of the Level of Consciousness
Modulation of Pain
Regulation of Motor Activity
Coordination of Vision (the Gaze Centers)
Control of Autonomic Activity
Clinical Connections
Summary
Applications
References -
Brainstem III: Organization, Blood Supply, and Clinical Correlates Learning Outcomes
Acronyms
Introduction
Organizational Principles For An Understanding Of Internal Brainstem Structure
Representative Cross Sections Through the Brainstem
Blood Supply of The Brainstem and Neurovascular Syndromes
Review of the Blood Supply
Clinical Connections
Medulla
Lateral Medullary Syndrome (Wallenberg’s Syndrome)
Medial Medullary Syndrome (Alternating Hypoglossal Hemiplegia)
Pons
Medial (Paramedian) Inferior Pontine Syndrome
Lateral Superior Pontine Syndrome (Syndrome of the Superior Cerebellar Artery)
Complete Basilar Syndrome
Locked-In Syndrome
Midbrain
Weber’s Syndrome
Benedikt’s Syndrome
Associated Signs
Summary
Applications
References
Part V Special Functional Systems of the CNS: Motor and Sensory Systems
-
Pain and Its Modulation Learning Outcomes
Acronyms
Introduction
Foundational Information
Anatomy and Function
The Periphery
Sensitization of the Pain System, Hyperalgesia, and Allodynia
Peripheral Sensitization
Peripheral Nerve Injury and Pain
The Spinal Cord
Central Sensitization
Ascending Systems
Projections to the Brainstem and Thalamus
Cerebral Cortex
Pain Modulation
Theories of Pain Modulation
Clinical Connections
Pain Management from the Periphery
Touch and Massage
Heat and Cold
Transcutaneous Electrical Nerve Stimulation
Common Drugs for the Management of Pain
Acupuncture
Chronic Pain
Clinical Connections
Summary
Applications
References -
Auditory and Vestibular Systems Learning Outcomes
Acronyms
Introduction
Inner Ear
Labyrinth
Hair Cells
Auditory System
Foundational Information
The Peripheral Apparatus
Outer Ear
Middle Ear (Tympanic Cavity)
Inner Ear
Sensory End Organs
Primary Afferents
Projections
Second-Order Neurons
Third-Order Neurons
Fourth-Order Neurons
Decussations
Function
Auditory Reflexes
Clinical Connections
Vestibular System
Foundational Information
Sensory End Organs
Utricular and Saccular Maculae (Otolith Organs)
Semicircular Canals
Primary Afferents
Vestibular Nuclei
Commissural Inhibitory System
The Vestibular Sensory System
Projections
Cerebral Cortex
Function
The Vestibular Motor System
Spinal Cord Projections
Reticular Formation
Extraocular Projections
Cerebellum
Reflexes
Vestibulocollic (Neck) Reflexes
Vestibulospinal Reflexes
Vestibulo-ocular Reflexes
Integration in the Vestibular System
Role in Postural Control
Convergence onto Neurons of the Vestibular Nuclei
Convergence onto Neurons of the Cerebral Cortex
Vestibular and Neck Reflexes
Clinical Connections
Summary
Applications
References -
Visual System Learning Outcomes
Acronyms
Introduction
Sensory End Organs and Primary Afferents
The Retina
Cell Types and Connections
Sensory Transduction in Rods and Cones
Ganglion Cells
Optic Disk and the Blind Spot
Blood Supply
Clinical Connections
Projections
Overview of Terminology
Primary Afferents
Second-Order Neurons
Optic Nerve, Chiasm, and Tract
Third-Order Neurons
Other Projections of Second-Order Optic Tract Axons
Hypothalamic
Midbrain
Processing of Functional Information
Neurons of the Geniculocalcarine System
Retinal Ganglion Cells
Neurons of the Lateral Geniculate Body
Neurons of the Primary Visual Cortex
Extraction of the Visual Pattern by Cells of the Visual Cortex
Higher Visual Processing
Visual Reflexes
Pupillary Size
Fixation Reflex
The Accommodation–Convergence Reaction (Near Reflex)
Clinical Connections
Summary
Applications
References -
Cerebellum and Basal Ganglia Learning Outcomes
Acronyms
Introduction
Cerebellum
Circuitry of the Cerebellum
Layers
Peduncles, Inputs, and Outputs
Cerebellar Input–Output Connections in Relation to Function
Archicerebellar Connections and Function
Paleocerebellar Connections and Function
Five Tracts of the Paleocerebellum
Neocerebellar Connections and Function
Motor Learning and the Cerebellum
Clinical Connections
Syndromes
Archicerebellar Syndrome
Paleocerebellar Syndrome
Neocerebellar Syndrome
Cerebellar Dysarthria
Physical Rehabilitation
Examination Strategies
Intervention Strategies
Basal Ganglia
Anatomy and Function of Circuits through the Basal Ganglia
The Concept of Disinhibition
Direct and Indirect Pathways
Parallel Channels
Clinical Connections
Parkinson’s Disease
Etiology
The Brain Disorder in PD: Pathophysiology
Pharmacological Management
Levodopa (L-Dopa)
Dopamine Receptor Agonists
Dopamine Metabolism Inhibitors
Anticholinergic Agents
Amantadine
Neurotrophic Factors
Surgical Interventions
Modern Pallidotomy and Subthalamotomy
Deep Brain Stimulation
Fetal Nigral Transplantation
Physical Rehabilitation
Examination Strategies
Intervention Strategies
Huntington’s Disease (Chorea)
The Genetic Abnormality in HD
Medical Management
Physical Rehabilitation
Examination Strategies
Intervention Strategies
Hemiballismus
Summary
Applications
References -
Voluntary Movement Learning Outcomes
Acronyms
Introduction
The Cerebral Cortex and Voluntary Movement
Cortical Areas Subserving Voluntary Movement
Frontal Cortex
Primary Motor Cortex (M1)
Premotor Cortex
Parietal Cortex
Limbic Areas
Connections of the Cortical Motor Areas
Cortical Connections
Subcortical Connections
The Control of Voluntary Movement
Perceptual Action System and Haptic Sensing
Independent Finger Movements in Other Functions
Grasping
Neuroanatomical Areas Controlling Grasping
Orienting Movements of the Eyes, Head, and Neck
Gait
Higher Cortical Processing and Control of Movement
Clinical Connections
Disorders of Gait
Apraxia
Ideational Apraxia
Ideomotor Apraxia
Kinetic Apraxia
Oral Apraxia (Facial-Oral Apraxia)
Apraxia and Aphasia
Hypothetical Scheme for the Learning and Execution of Goal-Directed Purposeful Movement
Motivation, the Decision to Act, and Learning
Planning
Execution
Automatization
Summary
Applications
References
Part VI Special Functional Systems of the CNS: Reflexes and Control
-
Autonomic Nervous System Learning Outcomes
Acronyms
Introduction
Autonomic System Overview
Basic Structure
Neurotransmitters
Sympathetic Nervous System
Parasympathetic Nervous System
Enteric Nervous System
Autonomic Reflexes
Baroreceptor Reflex
Vagal Reflexes
Sweating and Thermoregulation
Clinical Connections
Autonomic Dysfunction
Hypertension
Hypotension
Heart Rate Disorders
Asthma and Bronchospasm
Irritable Bowel Syndrome
Diabetes
Neurogenic Bladder Dysfunction
Summary
Applications
References -
Reflexes and Spinal Cord Mechanisms Learning Outcomes
Acronyms
Introduction
Spinal Reflexes
Monosynaptic Reflexes
Polysynaptic Reflexes
Somatic Reflexes
Flexor Reflex
Withdrawal Reflex
Crossed Extensor Reflex
Reciprocal Inhibition
Autonomic Reflexes
Defecation Reflex
Micturition Reflex
Baroreceptor Reflex
Clinical Connections
Reflex Testing
Summary
Applications
References -
Motor Control Systems Learning Outcomes
Acronyms
Introduction
Motor Control Hierarchy
Central Pattern Generators
Motor Cortex and Motor Planning
Basal Ganglia and Movement Regulation
Cerebellum and Coordination
Peripheral Motor Neurons
Spinal Motor Control
Reflexes in Motor Control
Movement Disorders
Clinical Connections
Parkinson’s Disease and Motor Control
Stroke and Motor Control
Cerebellar Lesions and Coordination Deficits
Motor Neuron Diseases
Examination and Diagnosis of Motor Control Disorders
Physical Rehabilitation
Summary
Applications
References -
Control of Posture and Locomotion Learning Outcomes
Acronyms
Introduction
Postural Control Systems
Sensory Inputs for Posture
Somatosensory Feedback
Vestibular Feedback
Visual Feedback
Motor Control of Posture
Spinal Mechanisms in Postural Control
Cerebellar and Basal Ganglia Contributions
Corticospinal Control
Balance Control and Gait
Gait Cycle and Phases of Locomotion
Central Pattern Generators for Locomotion
Postural Control in Walking
Clinical Connections
Gait Disorders
Parkinson’s Disease
Cerebellar Ataxia
Spinal Cord Injuries
Clinical Examination for Posture and Gait
Summary
Applications
References -
Sleep and Wakefulness Learning Outcomes
Acronyms
Introduction
Sleep States
Rapid Eye Movement (REM) Sleep
Non-REM (NREM) Sleep
Sleep Stages
Physiology of Sleep
Sleep-Wake Cycle Regulation
The Circadian Rhythm
Neurological Control of Sleep
Neurotransmitters Involved in Sleep
Sleep Disorders
Insomnia
Sleep Apnea
Narcolepsy
Parasomnias
Sleep Deprivation
Clinical Connections
Sleep and Cognitive Function
Summary
Applications
References
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