Analysis of Oligonucleotides and Their Related Substances 1st edition by Okafo George, Elder David, Webb Mike 1906799144 9781906799144
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Product details:
ISBN 10: 1906799144
ISBN 13: 9781906799144
Author: Okafo George, Elder David, Webb Mike
Oligonucleotides are growing in importance in the pharmaceutical and biotechnology industries as therapeutic medicines. However, their structure and analysis are challenging and require a different approach to existing medicinal products. This book reviews the most up-to-date analytical strategies for synthetic oligonucleotides. It discusses the importance of characterising impurities in oligonucleotides, the different chemical classes and their synthetic origins. It also focuses on current analytical methodologies and strategies for characterising synthetic oligonucleotides using modern techniques in chromatography and spectroscopy. This book will serve as an invaluable reference tool by giving guidance and tried-andtested approaches for characterising oligonucleotides.
Analysis of Oligonucleotides and Their Related Substances 1st Table of contents:
chapter 1 Introduction to oligonucleotides
chapter 2 Regulatory considerations and guidelines
chapter 3 Oligonucleotide synthesis and related substances
chapter 4 Analytical challenges and strategies
chapter 5 Chromatographic techniques
chapter 6 Mass spectrometry and structural characterization
chapter 7 Impurity profiling and control
chapter 8 Stability studies and degradation pathways
chapter 9 Method validation and lifecycle management
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Tags: Analysis, Oligonucleotides, Substances, Okafo George, Elder David, Webb Mike