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Antibody Drug Conjugates and Immunotoxins From Pre Clinical Development to Therapeutic Applications Cancer Drug Discovery and Development 2013th Edition by Gail Lewis Phillips ISBN 1489997008 978-1489997005

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Product details: 

ISBN 10: 1489997008

ISBN 13: 978-1489997005

Author: Gail Lewis Phillips

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Table of contents: 

Antibody Directed Delivery for Treatment of Cancer: Antibody Drug Conjugates and Immunotoxins.
Antibody-Drug Conjugate Development.
Components of ADC Development: Assay Methodologies and Challenges.
Clinical Pharmacology Strategies in the Development of Antibody-Drug Conjugates.
Predictive Biomarkers for Antibody-Drug Conjugates.
Factors Involved in the Design of Cytotoxic Payloads for Antibody-Drug Conjugates.
Linker Technology and Impact of Linker Design on ADC Properties.
Antibody-drug conjugates for the treatment of B-cell malignancies.
Targeting CD19 with SAR3419, an anti-CD19-Maytansinoid Conjugate for the Treatment of B Cell Malignancies.
Brentuximab Vedotin (SGN-35) for CD30 Positive Malignancies.
Trastuzumab Emtansine (T-DM1) for the Treatment of HER2-Positive Cancer.
CDX-011 (Glembatumumab Vedotin, CR011-vcMMAE).
Case Study: An Antibody-Drug Conjugate Targeting MUC16 for Ovarian Cancer.
EphA2 Immunoconjugate.
Anti-PSMA

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Gail Lewis Phillips,Antibody Drug,Conjugates,Immunotoxins,Clinical,Therapeutic,Applications Cancer

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