Dynamics of Engineered Artificial Membranes and Biosensors 1st Edition by William Hoiles, Vikram Krishnamurthy, Bruce Cornell ISBN 1108423507 978-1108423502

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Product details: 

ISBN 10: 1108423507

ISBN 13: 978-1108423502

Author: William Hoiles, Vikram Krishnamurthy, Bruce Cornell

Learn about the state of the art in building artificial membranes and synthetic biological devices, and in constructing mathematical models for their dynamics at multiple time and spatial scales with this comprehensive book. Drawing on recent advances in bioengineering and biochemistry, it describes how to engineer tethered bilayer lipid membranes, bioelectronic interfaces, high-resolution biosensors, and diagnostic devices for non-invasive cellular measurements and electroporation. Multi-physics models combining atomistic (molecular dynamics and coarse-grained molecular dynamics), mesoscopic (Poisson–Nernst–Planck), and macroscopic (reaction-rate theory) dynamics provide a complete structure-to-function description of these devices. Experiments and dynamic models explain how anti-microbial peptides penetrate membranes, how molecular machine biosensors built out of artificial membranes can detect femtomolar concentrations, and how electroporation can be controlled. Supported by atomistic simulation code online, this is essential reading for researchers, students and professionals in bioengineering, chemical engineering, biophysics, applied mathematics, and electrical engineering.

Table of contents: 

Part I. Background:

1. Motivation and outline

2. Biochemistry for engineers: a short primer

3. Engineered artificial membranes

Part II. Building Engineered Membranes, Devices and Experimental Results

4. Formation of engineered tethered membranes

5. Ion-channel switch biosensor

6. Physiochemical membrane platforms

7. Experimental measurement methods for engineered membranes

Part III. Dynamic Models for Artificial Membranes: Atoms-to-Device

8. Reaction-rate constrained models for engineered membranes

9. Reaction-rate constrained models for the ICS biosensor

10. Diffusion constrained continuum models of engineered membranes

11. Electroporation models in engineered artificial membranes

12. Electroporation measurements in engineered membranes

13. Electrophysiological response of ion channels and cells

14. Coarse-grained molecular dynamics

15. All-atom molecular dynamics simulation models

16. Closing summary for part III: from atoms to device

Appendices

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William Hoiles,Vikram Krishnamurthy,Bruce Cornell,Dynamics,Artificial Membranes,Biosensors