Clinical Biochemistry and Metabolic Medicine 8th ediiton by Martin Crook ISBN 1482213974 9781482213973

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ISBN 10: 1482213974
ISBN 13: 9781482213973
Author: Martin Crook

Whether you are following a problem-based, an integrated, or a more traditional medical course, clinical biochemistry is often viewed as one of the more challenging subjects to grasp. What you need is a single resource that not only explains the biochemical underpinnings of metabolic medicine, but also integrates laboratory findings with clinical p

Clinical Biochemistry and Metabolic Medicine 8th Table of contents:

Part I: Principles

1. Epidemiology

   • Part 1: Global Perspective

     • Introduction and Scope

     • History

     • Global Prevalence of Head and Neck Cancer

     • Etiology of Head and Neck Cancer

     • Global Scenario of Oral Potentially Malignant Disorders and Laryngeal Leukoplakia

     • Salivary Gland Neoplasms

     • Malignant Melanoma

     • The Future of Head and Cancer Epidemiology

   • Part 2: Human Papillomavirus–Related Head and Neck Cancer

     • Epidemiology of Oral Human Papillomavirus Infection

     • Association Between Oral Human Papillomavirus Infection and Oropharyngeal Cancers

     • Incidence Trends for Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma

     • Demographic Profile of Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma

     • Risk Factors for Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma

     • Clinical Implications for Human Papillomavirus Tumor Status

     • Preventive Implications

     • Future Directions

2. Cellular and Molecular Pathology

   • Squamous Cell Carcinoma and Variants

   • Sinonasal and Nasopharyngeal Neoplasms

   • Salivary Gland Neoplasms

   • Newly Defined Head and Neck Neoplasms

   • Staging of Head and Neck Cancer

   • Molecular Pathology of Head and Neck Tumors

3. Molecular Biology

   • Alteration of Cell Cycle Control: TP53

   • Alteration of Cell Cycle Control: CDKN2a (P16) and the Rb Pathway

   • Human Papillomavirus

   • Abnormal Squamous Differentiation and the Notch Pathway

   • Cell Growth and Survival: EGFR, Ras, and PI3K Pathways

   • Epigenetic Phenomena

   • Additional Pathways

   • Implications of Recent Findings

   • Conclusion

4. Oncoviruses

   • Historical Background

   • Human Papillomavirus

   • Epstein-Barr Virus

   • Merkel Cell Carcinoma Polyomavirus

   • Kaposi Sarcoma Herpesvirus

   • Conclusion

5. Diagnostic Imaging

   • Anatomic Imaging: Computed Tomography and Magnetic Resonance Imaging

   • Primary Site Evaluation by Imaging

   • Lymph Node Evaluation by Imaging

   • Physiologic Imaging: Positron Emission Tomography

   • Post-therapy Imaging: Recognizing Normal Postoperative Changes

   • Post-therapy Imaging: Imaging of Radiation-Induced Inflammatory Changes

   • Conclusion

6. Endoscopic Evaluation of the Upper Aerodigestive Tract

   • Endoscopy Laboratory

   • Low Technology

   • Summary

7. Virtual Surgical Planning

   • CAD/CAM: Virtual Surgical Planning and Execution

   • Case Examples

   • Discussion

   • Summary

8. Intraoperative Navigation

   • 3D Imaging

   • Computer-Aided Surgery Systems

9. Management of the Neck

   • Part 1: Neck Dissection

     • Patterns of Nodal Metastasis by Site of Primary Tumor

     • Indications for Neck Dissection

     • Elective Neck Irradiation

     • Conclusion

   • Part 2: Sentinel Lymph Node Biopsy

     • The Concept of SNB

     • Pathologic Evaluation

     • Advantages of SNB

     • Disadvantages and Limitations of SNB

     • Recent Developments

     • A Randomized Comparison with SND: The Need and the Hurdles

     • Conclusion

10. Microvascular Surgery

    • Selection of Method of Reconstruction

    • Surgical Planning and Preoperative Considerations

    • Intraoperative and Postoperative Considerations

    • Experience with Microvascular Head and Neck Reconstruction

    • Free Flaps Commonly Used in Head and Neck Reconstruction

    • Free Flap Complications and Outcomes

    • Microvascular Surgical Outcomes

    • Summary

11. Tissue Engineering

    • The Principles of Tissue Engineering

    • Developing the In Situ Engineering Graft at the Point of Care

    • Surgical Applications of In Situ Tissue Engineering Grafts

    • The Biologic Sequence of Bone Regeneration in In Situ Tissue-Engineered Grafts

    • Use of rhBMP-2/ACS and Purported Risk for Cancer

    • Conclusion

12. Maxillofacial Reconstruction and Prosthetic Rehabilitation

    • Virtual Surgical Planning

    • Classification for Reconstruction of Head and Neck Defects

    • Preoperative Assessment: Maxillary Defects

    • Preoperative Assessment: Mandibular Defects

    • Preoperative Assessment: Extraoral Defects

    • Summary

13. Radiation Therapy

    • Radiobiology in Head and Neck Cancer

    • Radiation Physics and Treatment Technique

    • Morbidity of Head and Neck Radiation

    • Radiotherapy for Specific Disease Sites

    • Conclusion

14. Chemotherapy

    • Early Chemotherapy Trials in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

    • Induction Chemotherapy Beyond Cisplatin/5-Fu

    • Human Papillomavirus–Positive Cancer of the Oropharynx

    • Summary Practice Guidelines

15. Immunotherapy

    • Immunology

    • Immunotherapy

16. Oral/Dental Oncology

    • The Role of the Oral/Dental Oncologist

    • Pretreatment Dental Evaluation

    • Oral and Mucosal Complications

    • Chronic Oral/Dental Complications

    • Removable Prosthetic Rehabilitation

    • Conclusion

17. Speech Pathology and Rehabilitation

    • The Role of the Speech Pathologist

    • Evaluation of the HNC Patient

    • Rehabilitation After HNC Treatment

Part II: Site-Specific Multidisciplinary Treatment

Section A: Oral Cavity

• 18. Early Tongue Cancer

• 19. Advanced Tongue Cancer

• 20. Advanced Tongue Cancer (Special Considerations Requiring Total Glossectomy)

• 21. Early Floor of Mouth Cancer

• 22. Advanced Floor of Mouth Cancer

• 23. Early Oromandibular Cancer

• 24. Advanced Oromandibular Cancer

• 25. Early Buccal Mucosa Cancer

• 26. Advanced Buccal Mucosa Cancer

• 27. Early Palatomaxillary Cancer

• 28. Advanced Palatomaxillary Cancer

• 29. Advanced Palatomaxillary Cancer (Special Considerations Related to Reconstruction)

• 30. Advanced Palatomaxillary Cancer (Special Considerations Related to Nasal Involvement)

• 31. Lip Cancer

Section B: Pharynx

• 32. Early HPV-Related Tonsil Cancer

• 33. Early HPV-Related Base of Tongue Cancer

• 34. Advanced HPV-Related Oropharynx Cancer

• 35. Advanced HPV-Unrelated Pharynx Cancer

  • Part 1: Advanced HPV-Negative Cancer of the Oropharynx and Hypopharynx

  • Part 2: Nasopharynx

• 36. Soft Palate Cancer

Section C: Larynx

• 37. Early Supraglottic Larynx Cancer

• 38. Advanced Supraglottic Larynx Cancer

• 39. Early Glottic Larynx Cancer

• 40. Advanced Larynx Cancer

• 41. Subglottic Larynx Cancer

Section D: Other

• 42. Major Salivary Gland Cancer

• 43. Melanoma

  • Cutaneous Melanoma

  • Mucosal Melanoma

• 44. Aggressive Non-melanoma Skin Cancer

• 45. Osteoradionecrosis

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