Clinical Biochemistry Metabolic and Clinical Aspects 3rd Edition by William Marshall, Márta Lapsley, Andrew Day, Stephen Bangert, Ruth Ayling ISBN 0702057185 9780702057182

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ISBN 10: 0702057185
ISBN 13: 9780702057182
Author: William Marshall, Márta Lapsley, Andrew Day, Stephen Bangert, Ruth Ayling

Metabolic and clinical aspects

For Elsevier: Content Strategist: J er emy Bowes Senior Content D evelopment Specialist: Ailsa Laing Senior Project Manager: Beula Chr istopher D esigner: Miles H itchen Illustrator: Char twell Illustr ations

CLIN ICAL BIO CH EMIST RY Metabolic and clinical aspects THIRD EDITION

Clinical Biochemistry Metabolic and Clinical Aspects 3rd Table of contents:

Chapter 1: Uses of Biochemical Data in Clinical Medicine

• Introduction

• Specific Uses of Biochemical Tests

• Conclusion

Chapter 2: Acquisition and Interpretation of Biochemical Data

• Introduction

• The Test Request

• Factors Affecting Test Results

• Interpretation of Results

• The Predictive Value of Tests

• Conclusion

• Acknowledgment

Chapter 3: Quality Aspects of Laboratory Medicine

• Introduction

• What is Quality?

• Quality Standards

• Clinical Quality Indicators

• Evidence-Based Clinical Biochemistry

• Point-of-Care Testing

• Conclusion

Chapter 4: Sodium, Water, and Potassium

• Physiology

• Disorders of Sodium Metabolism

• Disorders of Water Metabolism

• Disorders of Potassium Metabolism

• Conclusion

• Appendix 4.1: Formulae

• Appendix 4.2: Dynamic Function Tests

Chapter 5: Hydrogen Ion Homoeostasis and Tissue Oxygenation and Their Disorders

• Introduction

• The Physiological Role of Hydrogen Ions

• Hydrogen Ion Homoeostasis

• The Assessment of Acid–Base Status

• Disorders of Hydrogen Ion Homoeostasis

• Tissue Oxygenation

• Conclusion

Chapter 6: Calcium, Phosphate, and Magnesium

• Calcium Metabolism

• Phosphorus Metabolism

• Magnesium Metabolism

• Conclusion

• Appendix 6.1: Calcium Absorption Test

• Appendix 6.2: Analysis of Tubular Handling of Calcium

• Appendix 6.3: Classification of Pseudohypoparathyroidism

• Appendix 6.4: Estimation of TMP/GFR

• Appendix 6.5: Magnesium Retention Test

• Appendix 6.6: Renal Tubular Reabsorption of Magnesium

Chapter 7: The Kidneys, Renal Function, and Kidney Disease

• Anatomy

• Renal Function

• Renal Disease and Its Presentation

• The Assessment of Renal Function

• Acute Kidney Injury (Acute Renal Failure)

• Chronic Kidney Disease

• Conclusion

• Acknowledgment

Chapter 8: Proteinuria

• Introduction

• Protein Conservation by the Kidneys

• Normal Urinary Protein Content

• Proteinuria in Kidney Disease

• Microalbuminuria as a Marker of Risk

• Clinical Investigation of Proteinuria

• Acknowledgment

Chapter 9: Renal Tubular Disorders and Renal Stone Disease

• Introduction

• Renal Tubular Disorders

• Renal Calculi

• Conclusion

• Acknowledgment

• Appendix 9.1: Diagnosis of Renal Tubular Acidosis

Chapter 10: Clinical Biochemistry of Nutrition

• Introduction

• Nutritional Requirements

• Assessment of Nutritional Status

• Conclusion

• Acknowledgment

Chapter 11: Nutritional Disorders and Their Management

• Introduction

• Malnutrition

• Obesity

• Eating Disorders

• Diet in the Aetiology of Disease

• Therapeutic Diets, Dietary Supplements, and Nutraceuticals

• Provision of Nutrition Support

• Conclusion

• Acknowledgment

Chapter 12: Clinical Biochemistry of the Gastrointestinal Tract

• Introduction

• Mouth and Oesophagus

• Stomach

• Pancreas

• Small Bowel Bacterial Overgrowth

• Maldigestion and Malabsorption

• Intestinal Permeability

• Faecal Tests of Intestinal Inflammation

• The Acute Abdomen

Chapter 13: Assessment of Hepatic Function and Investigation of Jaundice

• Introduction

• Anatomy of the Liver

• Hepatic Regeneration

• Physiological Functions

• Liver Function Tests

• Uses of Liver Function Tests

• Abnormal Liver Function Tests in Asymptomatic Patients

• Normal Liver Function Tests in the Presence of Overt Liver Disease

• Role of Liver Function Tests in Assessing Prognosis

• Conclusion

Chapter 14: Acute and Chronic Liver Disease

• Classification of Liver Disease

• Acute Hepatitis and Its Sequelae

• Acute Liver Failure

• Chronic Hepatitis

• Primary Biliary Cirrhosis (PBC)

• Primary Sclerosing Cholangitis (PSC)

• Alcoholic Liver Disease

• The Concept of Cirrhosis

• Drugs and the Liver

• Neoplastic Disease of the Liver and Biliary Tract

• Parenteral Nutrition

• Bacterial Infections

• Inherited Metabolic Disorders Involving the Liver

• Liver Transplantation

• Conclusion

Chapter 15: Glucose Metabolism and the Pathophysiology of Diabetes Mellitus

• Physiology and Pathophysiology of Glucose Homoeostasis

• Classification and Diagnosis of Diabetes Mellitus

• Endocrine Associations with Diabetes

• Diabetes, Nutrition, and Growth

• Mechanisms of Diabetic Tissue Damage

• Conditions Associated with Inadequately Controlled Diabetes Mellitus

• Biochemical Measurements in Diabetes Mellitus

• Conclusion

• Acknowledgment

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