Clinical Chemistry With STUDENT CONSULT Access 7th edition by William Marshall, Stephen K Bangert, Márta Lapsley ISBN 0702056468 9780702056468

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ISBN 10: 0702056468
ISBN 13: 9780702056468
Author:  William Marshall, Stephen K Bangert, Márta Lapsley

Clinical Chemistry considers what happens to the body’s chemistry when affected by disease. Each chapter covers the relevant basic science and effectively applies this to clinical practice. It includes discussion on diagnostic techniques and patient management and makes regular use of case histories to emphasise clinical relevance, summarise chapter key points and to provide a useful starting point for examination revision.

The clear and engaging writing style appreciated by generations of readers has been retained in this new seventh edition, while the content has been thoroughly updated throughout. The approach and scope of this trusted text makes it ideal for integrated medical curricula for medical training and for students and practitioners of clinical and biomedical science. The complementary online version of the book, including additional self-assessment material, completes this superb learning package.

Clinical Chemistry With STUDENT CONSULT Access 7th Table of contents:

Biochemical Tests in Clinical Medicine

1. Water, Sodium, and Potassium

   • Water Balance: Fluid compartments in the body (intracellular, extracellular) and mechanisms controlling water balance (ADH, thirst).

   • Sodium: Main extracellular cation involved in fluid balance and blood pressure regulation.

   • Potassium: Major intracellular cation important for muscle and nerve function, and acid-base balance.

2. Hydrogen Ion Homeostasis and Blood Gases

   • Acid-Base Balance: Regulation of pH in the body (buffer systems, lungs, kidneys).

   • Blood Gas Analysis: Measurement of oxygen, carbon dioxide, pH, and bicarbonate to assess respiratory and metabolic function.

3. The Kidneys

   • Renal Function: Regulation of electrolytes, acid-base balance, and fluid homeostasis.

   • Tests: Creatinine, urea, urine tests, glomerular filtration rate (GFR).

4. The Liver

   • Liver Function Tests (LFTs): Measurement of enzymes (ALT, AST), bilirubin, albumin, and clotting factors to assess liver health.

   • Metabolism: Detoxification, protein synthesis, glycogen storage, and bile production.

5. The Gastrointestinal Tract

   • Digestive Function: Assessment of enzymes (amylase, lipase), liver function, and nutrient absorption.

   • Markers: Tests like stool analysis for pathogens or malabsorption syndromes.

6. The Hypothalamus and Pituitary Gland

   • Endocrine Regulation: Secretion of hormones (e.g., ACTH, TSH, growth hormone) that regulate other endocrine glands.

   • Tests: Hormonal assays to assess pituitary and hypothalamic function.

7. The Adrenal Glands

   • Hormone Production: Cortisol, aldosterone, catecholamines.

   • Tests: Measurement of adrenal hormones for disorders like Cushing’s syndrome, Addison’s disease, or pheochromocytoma.

8. The Thyroid Gland

   • Thyroid Function: Regulation of metabolism via thyroid hormones (T3, T4, and TSH).

   • Tests: Measurement of thyroid function for hypothyroidism, hyperthyroidism, or thyroiditis.

9. The Gonads

   • Sex Hormones: Estrogen, progesterone, testosterone, and their role in reproductive health.

   • Tests: Hormonal assays for fertility and sexual function.

10. Disorders of Carbohydrate Metabolism

    • Glucose Regulation: Insulin and glucagon in glucose homeostasis.

    • Tests: Fasting blood glucose, HbA1c, glucose tolerance test for diagnosing diabetes mellitus.

11. Calcium, Phosphate, and Magnesium

    • Mineral Metabolism: Regulation of bone health, muscle function, and nervous system.

    • Tests: Measurement of calcium, phosphate, and magnesium levels in the blood.

12. Plasma Protein and Enzymes

    • Protein Synthesis: Albumin, globulin, and fibrinogen for evaluating liver function and immune response.

    • Enzymatic Activity: Enzyme markers for tissue damage (e.g., ALT, AST, alkaline phosphatase).

13. Lipids, Lipoproteins, and Cardiovascular Disease

    • Lipid Profile: Cholesterol (HDL, LDL), triglycerides.

    • Tests: Blood lipid analysis to assess cardiovascular risk.

14. The Locomotor and Nervous Systems

    • Neurotransmission and Muscle Function: Involvement of neurotransmitters, ions, and muscle enzymes.

    • Tests: Enzyme assays (e.g., creatine kinase) and neurochemical analysis.

15. Inherited Metabolic Disease

    • Genetic Disorders: Inborn errors of metabolism (e.g., phenylketonuria, galactosemia).

    • Tests: Screening and diagnostic tests for inherited metabolic conditions.

16. Disorders of Haemoproteins, Porphyrins, and Iron

    • Hemoglobinopathies: Disorders of hemoglobin and heme biosynthesis (e.g., sickle cell anemia, porphyria).

    • Tests: Blood tests for hemoglobin levels, iron studies, and porphyrin profiling.

17. Metabolic Aspects of Malignant Disease

    • Cancer Metabolism: Altered metabolic pathways in cancer cells (e.g., glycolysis, oxidative phosphorylation).

    • Tests: Tumor markers and metabolic profiling in cancer patients.

18. Therapeutic Drug Monitoring and Chemical Aspects of Toxicology

    • Drug Levels: Monitoring of therapeutic drug levels to ensure efficacy and prevent toxicity.

    • Toxicology: Detection of toxic substances (e.g., heavy metals, drugs, poisons).

19. Clinical Nutrition

    • Nutritional Assessment: Macronutrients, micronutrients, and vitamins.

    • Tests: Serum tests for nutritional deficiencies and metabolic responses.

20. Clinical Chemistry at the Extremes of Age

    • Age-Related Changes: Biochemical changes in elderly and pediatric patients.

    • Tests: Age-specific reference ranges and tests for growth, aging, and developmental disorders.

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Tags: William Marshall, Stephen K Bangert, Márta Lapsley, Clinical Chemistry, STUDENT CONSULT