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Clinical Chemistry Principles Techniques and Correlations 7th Edition by Michael Bishop ISBN 1496310179 9781496310170

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ISBN 10: 1496310179
ISBN 13: 9781496310170
Author: Michael Bishop

In its Seventh Edition, this acclaimed Clinical Chemistry continues to be the most student-friendly clinical chemistry text available. This edition not only covers the how of clinical testing but also places greater emphasis on the what, why, and when in order to help today’s students fully understand the implications of the information covered, as well as the applicability of this crucial topic in practice. With clear explanations that strike just the right balance of analytic principles, techniques, and correlation of results with disease states, this edition has been fully updated with the latest information to help keep today’s students at the forefront of today’s science. New case studies, practice questions, and exercises provide ample opportunities to review and apply the topics covered through the text.

Clinical Chemistry Principles Techniques and Correlations 7th Table of contents:

PART 1. Basic Principles and Practice of Clinical Chemistry

Chapter 1. Basic Principles and Practices

  • Units of Measure

  • Reagents

  • Clinical Laboratory Supplies

  • Basic Separation Techniques

  • Laboratory Mathematics and Calculations

  • Specimen Considerations

  • Questions

  • References

Chapter 2. Laboratory Safety and Regulations

  • Laboratory Safety and Regulations

  • Safety Awareness for Clinical Laboratory Personnel

  • Safety Equipment

  • Biologic Safety

  • Chemical Safety

  • Radiation Safety

  • Fire Safety

  • Control of Other Hazards

  • Disposal of Hazardous Materials

  • Accident Documentation and Investigation

  • Questions

  • Bibliography and Suggested Reading

Chapter 3. Method Evaluation

  • Basic Concepts

  • Method Evaluation

  • Quality Control

  • Reference Interval Studies

  • Diagnostic Efficiency

  • Practice Problems

  • Questions

  • Online Resources

  • References

Chapter 4. Lean Six Sigma Methodology for Quality Improvement in the Clinical Chemistry Laboratory

  • Lean Six Sigma Methodology

  • Adoption and Implementation of Lean Six Sigma

  • Process Improvement

  • Measurements of Success Using Lean and Six Sigma

  • Lean Six Sigma Applications in the Laboratory and the Greater Health-Care System

  • Practical Application of Six Sigma Metrics

  • Conclusions

  • Acknowledgments

  • Questions

  • References

Chapter 5. Analytic Techniques

  • Spectrophotometry

  • Electrochemistry

  • Electrophoresis

  • Osmometry

  • Questions

  • References

Chapter 6. Chromatography and Mass Spectrometry

  • Chromatography

  • Mass Spectrometry

  • Applications of MS in the Clinical Laboratory

  • Questions

  • References

Chapter 7. Principles of Clinical Chemistry Automation

  • History of Automated Analyzers

  • Driving Forces Toward More Automation

  • Basic Approaches to Automation

  • Steps in Automated Analysis

  • Selection of Automated Analyzers

  • Total Laboratory Automation

  • Future Trends in Automation

  • Questions

  • References

Chapter 8. Immunochemical Techniques

  • Immunoassays

  • Questions

  • References

Chapter 9. Molecular Theory and Techniques

  • Nucleic Acid-Based Techniques

  • Questions

  • References

Chapter 10. Point-of-Care Testing

  • Introduction

  • Laboratory Regulations

  • Implementation

  • Quality Management

  • POC Applications

  • Informatics and POCT

  • Questions

  • References

PART 2. Clinical Correlations and Analytic Procedures

Chapter 11. Amino Acids and Proteins

  • Amino Acids

  • Proteins

  • Plasma Proteins

  • Other Proteins of Importance

  • Total Protein Abnormalities

  • Methods of Analysis

  • Proteins in Other Body Fluids

  • Questions

  • References

Chapter 12. Nonprotein Nitrogen Compounds

  • Urea

  • Uric Acid

  • Creatinine/Creatine

  • Ammonia

  • Questions

  • References

Chapter 13. Enzymes

  • General Properties and Definitions

  • Enzyme Classification and Nomenclature

  • Enzyme Kinetics

  • Enzymes of Clinical Significance

  • Questions

  • References

Chapter 14. Carbohydrates

  • General Description of Carbohydrates

  • Hyperglycemia

  • Hypoglycemia

  • Role of Laboratory in Differential Diagnosis and Management of Patients with Glucose Metabolic Alterations

  • Questions

  • References

Chapter 15. Lipids and Lipoproteins

  • Lipid Chemistry

  • General Lipoprotein Structure

  • Lipoprotein Physiology and Metabolism

  • Lipid and Lipoprotein Population Distributions

  • Diagnosis and Treatment of Lipid Disorders

  • Lipid and Lipoprotein Analyses

  • Standardization of Lipid and Lipoprotein Assays

  • Questions

  • References

Chapter 16. Electrolytes

  • Water

  • The Electrolytes

  • Anion Gap

  • Electrolytes and Renal Function

  • Questions

  • References

Chapter 17. Blood Gases, pH, and Buffer Systems

  • Definitions: Acid, Base, and Buffer

  • Acid-Base Balance

  • Assessment of Acid-Base Homeostasis

  • Oxygen and Gas Exchange

  • Measurement

  • Quality Assurance

  • Questions

  • References

Chapter 18. Trace and Toxic Elements

  • Methods and Instrumentation

  • Aluminum

  • Arsenic

  • Cadmium

  • Chromium

  • Copper

  • Iron

  • Lead

  • Mercury

  • Manganese

  • Molybdenum

  • Selenium

  • Zinc

  • Questions

  • Bibliography

  • References

Chapter 19. Porphyrins and Hemoglobin

  • Porphyrins

  • Hemoglobin

  • Myoglobin

  • Questions

  • References

PART 3. Assessment of Organ System Functions

Chapter 20. Hypothalamic and Pituitary Function

  • Embryology and Anatomy

  • Functional Aspects of the Hypothalamic-Hypophyseal Unit

  • Hypophysiotropic or Hypothalamic Hormones

  • Anterior Pituitary Hormones

  • Pituitary Tumors

  • Growth Hormone

  • Prolactin

  • Hypopituitarism

  • Posterior Pituitary Hormones

  • Questions

  • References

Chapter 21. Adrenal Function

  • The Adrenal Gland: An Overview

  • Embryology and Anatomy

  • The Adrenal Cortex by Zone

  • Diagnosis of Primary Aldosteronism

  • Adrenal Cortical Physiology

  • Adrenal Insufficiency (Addison’s Disease)

  • Hypercortisolism

  • Cushing’s Syndrome

  • Adrenal Androgens

  • The Adrenal Medulla

  • Adrenal “Incidentaloma”

  • Questions

  • References

Chapter 22. Gonadal Function

  • The Testes

  • The Ovaries

  • Questions

  • References

Chapter 23. The Thyroid Gland

  • The Thyroid

  • Tests for Thyroid Evaluation

  • Other Tools for Thyroid Evaluation

  • Disorders of the Thyroid

  • Drug-Induced Thyroid Dysfunction

  • Nonthyroidal Illness

  • Thyroid Nodules

  • Questions

  • References

Chapter 24. Calcium Homeostasis and Hormonal Regulation

  • Calcium Homeostasis

  • Hormonal Regulation of Calcium Metabolism

  • Organ System Regulation of Calcium Metabolism

  • Hypercalcemia

  • Hypocalcemia

  • Metabolic Bone Diseases

  • Secondary Hyperparathyroidism in Renal Failure

  • Questions

  • References

Chapter 25. Liver Function

  • Anatomy

  • Biochemical Functions

  • Liver Function Alterations During Disease

  • Assessment of Liver Function/Liver Function Tests

  • Questions

  • References

Chapter 26. Laboratory Markers of Cardiac Damage and Function

  • Cardiac Ischemia, Angina, and Heart Attacks

  • The Pathophysiology of Atherosclerosis

  • Markers of Cardiac Damage

  • Cardiac Injury Beyond MI

  • Laboratory Workup for Heart Failure

  • Use of Natriuretic Peptides and Troponins

  • Markers of CHD Risk

  • Markers of Pulmonary Embolism

  • Summary

  • Questions

  • References

Chapter 27. Renal Function

  • Renal Anatomy

  • Renal Physiology

  • Analytic Procedures

  • Pathophysiology

  • Questions

  • References

Chapter 28. Pancreatic Function and Gastrointestinal Function

  • Physiology of Pancreatic Function

  • Diseases of the Pancreas

  • Tests of Pancreatic Function

  • Physiology and Biochemistry of Gastric Secretion

  • Clinical Aspects of Gastric Analysis

  • Tests of Gastric Function

  • Intestinal Physiology

  • Clinicopathologic Aspects of Intestinal Function

  • Tests of Intestinal Function

  • Questions

  • Suggested Reading

  • References

Chapter 29. Body Fluid Analysis

  • Amniotic Fluid

  • Cerebrospinal Fluid

  • Sweat

  • Synovial Fluid

  • Serous Fluids

  • Questions

  • References

PART 4. Specialty Areas of Clinical Chemistry

Chapter 30. Therapeutic Drug Monitoring

  • Routes of Administration

  • Absorption

  • Drug Distribution

  • Free Versus Bound Drugs

  • Metabolism

  • Drug Elimination

  • Pharmacokinetics

  • Sample Collection

  • Pharmacogenomics

  • Cardioactive Drugs

  • Antibiotics

  • Antiepileptic Drugs

  • Psychoactive Drugs

  • Immunosuppressive Drugs

  • Antineoplastics

  • Questions

  • Suggested Readings

  • References

Chapter 31. Toxicology

  • Xenobiotics, Poisons, and Toxins

  • Routes of Exposure

  • Dose-Response Relationship

  • Analysis of Toxic Agents

  • Toxicology of Specific Agents

  • Toxicology of Therapeutic Drugs

  • Toxicology of Drugs of Abuse

  • Questions

  • References

Chapter 32. Circulating Tumor Markers: Basic Concepts and Clinical Applications

  • Types of Tumor Markers

  • Applications of Tumor Marker Detection

  • Laboratory Considerations for Tumor Marker Measurement

  • Frequently Ordered Tumor Markers

  • Future Directions

  • Questions

  • Suggested Reading

  • References

Chapter 33. Nutrition Assessment

  • Nutrition Care Process: Overview

  • Nutrition Assessment

  • Biochemical Markers: Macronutrients

  • Biochemical Markers: Miscellaneous

  • Biochemical Markers: Micronutrients

  • Questions

  • References

Chapter 34. Clinical Chemistry and the Geriatric Patient

  • The Aging of America

  • Aging and Medical Science

  • General Physiologic Changes with Aging

  • Effects of Age on Laboratory Testing

  • Establishing Reference Intervals for the Elderly

  • Preanalytical Variables Unique to Geriatric Patients

  • Diseases Prevalent in the Elderly

  • Age-Associated Changes in Drug Metabolism

  • Atypical Presentations of Common Diseases

  • Impact of Exercise and Nutrition on Chemistry Results in the Elderly

  • Questions

  • References

Chapter 35. Clinical Chemistry and the Pediatric Patient

  • Developmental Changes from Neonate to Adult

  • Phlebotomy and Instrumentation for Pediatric Samples

  • Point-of-Care Analysis in Pediatrics

  • Regulation of Blood Gases and pH in Neonates and Infants

  • Regulation of Electrolytes and Water: Renal Function

  • Development of Liver Function

  • Calcium and Bone Metabolism in Pediatrics

  • Endocrine Function in Pediatrics

  • Development of the Immune System

  • Genetic Diseases

  • Drug Metabolism and Pharmacokinetics

  • Questions

  • References

Index

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