CLINICAL CHEMISTRY Principles Techniques and Correlations 7th edition by Michael Bishop ISBN 1451189192 978-1451189193
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ISBN 10: 1451189192
ISBN 13: 978-1451189193
Author: Michael Bishop
In its Seventh Edition, this acclaimed Clinical Chemistry continues to be the most student-friendly clinical chemistry text available. This edition not only covers the how of clinical testing but also places greater emphasis on the what, why, and when in order to help today’s students fully understand the implications of the information covered, as well as the applicability of this crucial topic in practice. With clear explanations that strike just the right balance of analytic principles, techniques, and correlation of results with disease states, this edition has been fully updated with the latest information to help keep today’s students at the forefront of today’s science. New case studies, practice questions, and exercises provide ample opportunities to review and apply the topics covered through the text.
CLINICAL CHEMISTRY Principles Techniques and Correlations 7th Table of contents:
PART 1. Basic Principles and Practice of Clinical Chemistry
Chapter 1. Basic Principles and Practices
Units of Measure
Reagents
Clinical Laborat ory Suplies
Basic Separation Techniques
Laboratory Mathematics and Calculations
Specimen Considerat ions
QUESTIONS
REFERENCES
Chapter 2. Laboratory Safety and Regulations
LABORATORY SAFETY AND REGULATIONS
SAFETY AWARENES FOR CLINICAL LABORATORY PERSONEL
SAFETY EQUIPMENT
BIOLOGIC SAFETY
CHEMICAL SAFETY
RADIATION SAFETY
FIRE SAFETY
CONTROL OF OTHER HAZARDS
DISPOSAL OF HAZARDOUS MATERIALS
ACCIDENT DOCUMENTATION AND INVESTIGATION
QUESTIONS
BIBLIOGRAPHY AND SUGGESTED READING
Chapter 3. Method Evaluation
Basic Concepts
Method Evaluation
Quality Control
Reference Interval Studies
Diagnostic Efficiency
Practice Problems
QUESTIONS
Online Resources
REFERENCES
Chapter 4. Lean Six Sigma Methodology for Quality Improvement in the Clinical Chemistry Laboratory
LEAN SIX SIGMA METHODOLOGY
ADOPTION AND IMPLEMENTATION OF LEAN SIX SIGMA
PROCES IMPROVEMENT
MEASUREMENTS OF SUCCES USING LEAN AND SIX SIGMA
LEAN SIX SIGMA APPLICATIONS IN THE LABORATORY AND THE GREATER HEALTH-CARE SYSTEM
PRACTICAL APPLICATION OF SIX SIGMA METRICS
CONCLUSIONS
ACKNOWLEDGMENTS
QUESTIONS
REFERENCES
Chapter 5. Analytic Techniques
SPECTROPHOTOMETRY
ELECTROCHEMISTRY
ELECTROPHORESIS
OSMOMETRY
QUESTIONS
REFERENCES
Chapter 6. Chromatography and Mass Spectrometry
Chromat ography
Mass Spectrometry
APPLICATIONS OF MS IN THE CLINICAL LABORATORY
Questions
REFERENCES
Chapter 7. Principles of Clinical Chemistry Automation
HISTORY OF AUTOMATED ANALYZERS
DRIVING FORCES TOWARD MORE AUTOMATION
BASIC APPROACHES TO AUTOMATION
STEPS IN AUTOMATED ANALYSIS
SELECTION OF AUTOMATED ANALYZERS
TOTAL LABORATORY AUTOMATION
FUTURE TRENDS IN AUTOMATION
QUESTIONS
REFERENCES
Chapter 8. Immunochemical Techniques
Imunoassays
Questions
references
Chapter 9. Molecular Theory and Techniques
NUCLEIC ACID-BASED TECHNIQUES
QUESTIONS
REFERENCES
Chapter 10. Point-of-Care Testing
INTRODUCTION
LABORATORY REGULATIONS
IMPLEMENTATION
QUALITY MANAGEMENT
POC APPLICATIONS
INFORMATICS AND POCT
QUESTIONS
REFERENCES
PART 2. Clinical Correlations and Analytic Procedures
Chapter 11. Amino Acids and Proteins
AMINO ACIDS
PROTEINS
PLASMA PROTEINS
OTHER PROTEINS OF IMPORTANCE
TOTAL PROTEIN ABNORMALITIES
METHODS OF ANALYSIS
PROTEINS IN OTHER BODY FLUIDS
QUESTIONS
REFERENCES
Chapter 12. Nonprotein Nitrogen Compounds
UREA
URIC ACID
CREATININE/CREATINE
AMMONIA
QUESTIONS
REFERENCES
Chapter 13. Enzymes
GENERAL PROPERTIES AND DEFINITIONS
ENZYME CLASSIFICATION AND NOMENCLATURE
ENZYME KINETICS
ENZYMES OF CLINICAL SIGNIFICANCE
QUESTIONS
REFERENCES
Chapter 14. Carbohydrates
GENERAL DESCRIPTION OF CARBOHYDRATES
HYPERGLYCEMIA
HYPOGLYCEMIA
ROLE OF LABORATORY IN DIFERENTIAL DIAGNOSIS AND MANAGEMENT OF PATIENTS WITH GLUCOSE METABOLIC ALTERA
QUESTIONS
REFERENCES
Chapter 15. Lipids and Lipoproteins
LIPID CHEMISTRY
GENERAL LIPOPROTEIN STRUCTURE
LIPOPROTEIN PHYSIOLOGY AND METABOLISM
LIPID AND LIPOPROTEIN POPULATION DISTRIBUTIONS
DIAGNOSIS AND TREATMENT OF LIPID DISORDERS
LIPID AND LIPOPROTEIN ANALYSES
STANDARDIZATION OF LIPID AND LIPOPROTEIN ASSAYS
QUESTIONS
REFERENCES
Chapter 16. Electrolytes
WATER
THE ELECTROLYTES
ANION GAP
ELECTROLYTES AND RENAL FUNCTION
QUESTIONS
REFERENCES
Chapter 17. Blood Gases, pH, and Buffer Systems
DEFINITIONS: ACID, BASE, AND BUFFER
ACID-BASE BALANCE
ASSESSMENT OF ACID-BASE HOMEOSTASIS
OXYGEN AND GAS EXCHANGE
MEASUREMENT
QUALITY ASSURANCE
QUESTIONS
REFERENCES
Chapter 18. Trace and Toxic Elements
METHODS AND INSTRUMENTATION
ALUMINUM
ARSENIC
CADMIUM
CHROMIUM
COPPER
IRON
LEAD
MERCURY
MANGANESE
MOLYBDENUM
SELENIUM
ZINC
QUESTIONS
BIBLIOGRAPHY
REFERENCES
Chapter 19. Porphyrins and Hemoglobin
PORPHYRINS
HEMOGLOBIN
MYOGLOBIN
QUESTIONS
REFERENCES
PART 3. Assessment of Organ System Functions
Chapter 20. Hypothalamic and Pituitary Function
EMBRYOLOGY AND ANATOMY
FUNCTIONAL ASPECTS OF THE HYPOTHALAMIC-HYPOPHYSEAL UNIT
HYPOPHYSIOTROPIC OR HYPOTHALAMIC HORMONES
ANTERIOR PITUITARY HORMONES
PITUITARY TUMORS
GROWTH HORMONE
PROLACTIN
HYPOPITUITARISM
POSTERIOR PITUITARY HORMONES
QUESTIONS
REFERENCES
Chapter 21. Adrenal Function
THE ADRENAL GLAND: AN OVERVIEW
EMBRYOLOGY AND ANATOMY
THE ADRENAL CORTEX BY ZONE
DIAGNOSIS OF PRIMARY ALDOSTERONISM
ADRENAL CORTICAL PHYSIOLOGY
ADRENAL INSUFFICIENCY (ADDISON’S DISEASE)
HYPERCORT ISOLISM
CUSHING’S SYNDROME
ADRENAL ANDROGENS
THE ADRENAL MEDULLA
ADRENAL “INCIDENTA LOMA”
QUESTIONS
REFERENCES
Chapter 22. Gonadal Function
THE TESTES
THE OVARIES
QUESTIONS
REFERENCES
Chapter 23. The Thyroid Gland
The Thyroid
Tests For Thyroid Evaluation
Other Tools For Thyroid Evaluation
Disorders of The Thyroid
Drug-Induced Thyroid Dysfunction
Nonthyroidal Illness
Thyroid Nodules
Questions
References
Chapter 24. Calcium Homeostasis and Hormonal Regulation
CALCIUM HOMEOSTASIS
HORMONAL REGULATION OF CALCIUM METABOLISM
ORGAN SYSTEM REGULATION OF CALCIUM METABOLISM
HYPERCALCEMIA
HYPOCALCEMIA
METABOLIC BONE DISEASES
SECONDARY HYPERPARAT HYROIDISM IN RENAL FAILURE
QUESTIONS
REFERENCES
Chapter 25. Liver Function
ANATOMY
BIOCHEMICAL FUNCTIONS
LIVER FUNCTION ALTERATIONS DURING DISEASE
ASSESSMENT OF LIVER FUNCTION/LIVER FUNCTION TESTS
QUESTIONS
REFERENCES
Chapter 26. Laboratory Markers of Cardiac Damage and Function
CARDIAC ISCHEMIA, ANGINA, AND HEART ATTACKS
THE PAT HOPHYSIOLOGY OF ATHEROSCLEROSIS, THE DISEASE PROCESS UNDERLYING MI
MARKERS OF CARDIAC DAMAGE
CARDIAC INJURY OCURS IN MANY DISEASE PROCESSES, BEYOND MI
THE LABORAT ORY WORKUP OF PAT IENTS SUSPECTED OF HEART FAILURE AND THE USE OF CARDIAC BIOMARKERS IN
THE USE OF NATRIURETIC PEPTIDES AND TROPONINS IN THE DIAGNOSIS AND RISK STRATIFICATION OF HEART FAIL
MARKERS OF CHD RISK
MARKERS OF PULMONARY EMBOLISM
SUMARY
QUESTIONS
REFERENCES
Chapter 27. Renal Function
RENAL ANATOMY
RENAL PHYSIOLOGY
ANALYTIC PROCEDURES
PATHOPHYSIOLOGY
QUESTIONS
REFERENCES
Chapter 28. PANCREATIC FUNCTION AND GASTROINTESTINAL FUNCTION
PHYSIOLOGY OF PANCREATIC FUNCTION
DISEASES OF THE PANCREAS
TESTS OF PANCREATIC FUNCTION
PHYSIOLOGY AND BIOCHEMISTRY OF GASTRIC SECRETION
CLINICAL ASPECTS OF GASTRIC ANALYSIS
TESTS OF GASTRIC FUNCTION
INTESTINAL PHYSIOLOGY
CLINICOPAT HOLOGIC ASPECTS OF INTESTINAL FUNCTION
TESTS OF INTESTINAL FUNCTION
QUESTIONS
SUGGESTED READING
REFERENCES
Chapter 29. Body Fluid Analysis
AMNIOTIC FLUID
CEREBROSPINAL FLUID
SWEAT
SYNOVIAL FLUID
SEROUS FLUIDS
QUESTIONS
REFERENCES
PART 4. Specialty Areas of Clinical Chemistry
Chapter 30. Therapeutic Drug Monitoring
ROUTES OF ADMINISTRATION
ABSORPTION
DRUG DISTRIBUTION
FREE VERSUS BOUND DRUGS
METABOLISM
DRUG ELIMINATION
PHARMACOKINETICS
SAMPLE COLLECTION
PHARMACOGENOMICS
CARDIOACTIVE DRUGS
ANTIBIOTICS
ANTIEPILEPTIC DRUGS
PSYCHOACTIVE DRUGS
IMUNOSUPRESSIVE DRUGS
ANTINEOPLASTICS
QUESTIONS
SUGGESTED READINGS
REFERENCES
Chapter 31. Toxicology
XENOBIOTICS, POISONS, AND TOXINS
ROUTES OF EXPOSURE
DOSE-RESPONSE RELATIONSHIP
ANALYSIS OF TOXIC AGENTS
TOXICOLOGY OF SPECIFIC AGENTS
TOXICOLOGY OF THERAPEUTIC DRUGS
TOXICOLOGY OF DRUGS OF ABUSE
QUESTIONS
REFERENCES
Chapter 32. Circulating Tumor Markers: Basic Concepts and Clinical Applications
TYPES OF TUMOR MARKERS
APPLICATIONS OF TUMOR MARKER DETECTION
LABORAT ORY CONSIDERATIONS FOR TUMOR MARKER MEASUREMENT
FREQUENTLY ORDERED TUMOR MARKERS
FUTURE DIRECTIONS
QUESTIONS
SUGGESTED READING
REFERENCES
Chapter 33. Nutrition Assessment
NUTRITION CARE PROCESS: OVERVIEW
NUTRITION ASSESSMENT
BIOCHEMICAL MARKERS: MACRONUTRIENTS
BIOCHEMICAL MARKERS: MISCELLANEOUS
BIOCHEMICAL MARKERS: MICRONUTRIENTS
QUESTIONS
REFERENCES
Chapter 34. Clinical Chemistry and the Geriatric Patient
THE AGING OF AMERICA
AGING AND MEDICAL SCIENCE
GENERAL PHYSIOLOGIC CHANGES WITH AGING
EFFECTS OF AGE ON LABORATORY TESTING
ESTABLISHING REFERENCE INTERVALS FOR THE ELDERLY
PREANALYTICAL VARIABLES UNIQUE TO GERIATRIC PATIENTS
DISEASES PREVALENT IN THE ELDERLY
AGE-ASSOCIATED CHANGES IN DRUG METABOLISM
ATYPICAL PRESENTATIONS OF COMMON DISEASES
THE IMPACT OF EXERCISE AND NUTRITION ON CHEMISTRY RESULTS IN THE ELDERLY
QUESTIONS
REFERENCES
Chapter 35. Clinical Chemistry and the Pediatric Patient
DEVELOPMENTAL CHANGES FROM NEONATE TO ADULT
PHLEBOTOMY AND CHOICE OF INSTRUMENTATION FOR PEDIATRIC SAMPLES
POINT-OF-CARE ANALYSIS IN PEDIATRICS
REGULATION OF BLOOD GASES AND PH IN NEONATES AND INFANTS
REGULATION OF ELECTROLYTES AND WATER: RENAL FUNCTION
DEVELOPMENT OF LIVER FUNCTION
CALCIUM AND BONE METABOLISM IN PEDIATRICS
ENDOCRINE FUNCTION IN PEDIATRICS
DEVELOPMENT OF THE IMUNE SYSTEM
GENETIC DISEASES
DRUG METABOLISM AND PHARMACOKINETICS
QUESTIONS
REFERENCES
Index
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