DNA Methylation and Complex Human Disease 1st edition by Michel Neidhart – Ebook PDF Instant Download/Delivery: 0124201946, 978-0124201941
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ISBN 10: 0124201946
ISBN 13: 978-0124201941
Author: Michel Neidhart
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies.
This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease.
Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.
- Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity
- Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field
- Describes wholly new concepts, including the linking of metabolic pathways with epigenetics
- Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
DNA Methylation and Complex Human Disease 1st Table of contents:
Chapter 1. DNA Methylation – Introduction
1.1 Epigenetics
1.2 Histone Modifications
1.3 DNA Methylation
1.4 Methyl-Binding Domain Proteins
1.5 DNA Demethylation
1.6 DNA Hydroxymethylation
1.7 Differentially Methylated Regions
1.8 Nutriepigenomics
References
Chapter 2. DNA Methylation and Epigenetic Biomarkers in Cancer
2.1 Introduction
2.2 Cancerogenesis
2.3 Epimutations in Cancer
2.4 Conclusion
References
Chapter 3. DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases
3.1 Introduction
3.2 Autoimmunity
3.3 Metabolic Diseases
3.4 Developmental Diseases
3.5 Psychiatric Diseases
3.6 Conclusion
References
Chapter 4. DNA Methylation and Environmental Factors
4.1 Introduction
4.2 Impact of the Environment in Early Life
4.3 Nutritional Factors
4.4 Adverse Environmental Factors
4.5 Immune Activation
4.6 Maternal Mood and Experience in Early Life
4.7 Physical Exercise
4.8 Conclusion
References
Chapter 5. DNA Methylation and Epidemiology
5.1 Introduction
5.2 Endocrine Disrupting Chemicals
5.3 Epigenomics and Breast Cancer
5.4 Tobacco Smoking
5.5 Conclusion
References
Chapter 6. DNA Methylation and Viral Infections
6.1 Introduction
6.2 Virus Infection and Methylation Changes
6.3 Virus Infections, Dna Methylation, and Cancer
6.4 Endogenous Retroviruses
6.5 Conclusion
References
Chapter 7. DNA Methylation and Cancer
7.1 Introduction
7.2 Maintenance and Plasticity of the Epigenome
7.3 DNA Methylation, CpG Islands and CpG Shores
7.4 Aberrant DNA Methylation in Cancer
7.5 Epimutations, Heritable Alterations in Cancer
7.6 Epimutations of Epigenetic Regulators
7.7 Epigenetic Interplays
7.8 Reactivation of Silenced Tumor Suppressor Genes
7.9 Conclusion
References
Chapter 8. DNA Methylation in Breast and Ovarian Carcinomas
8.1 Introduction
8.2 Hormonal Receptors
8.3 Hypomethylated Genes
8.4 Hypermethylated Genes
8.5 Conclusion
References
Chapter 9. DNA Methylation in Acquired Drug Resistance
9.1 Introduction
9.2 DNA Methylation and Acquired Drug Resistance
9.3 Mechanisms of Acquired Drug Resistance
9.4 Conclusion
References
Chapter 10. DNA Methylation and Endocrinology
10.1 Introduction
10.2 Imprinted Disorders
10.3 Rapid Promoter Methylation/Demethylation Processes
10.4 Exposure to Stress
10.5 Maternal and Sexual Behavior
10.6 Exposure to Endocrine Disruptors
10.7 Obesity and Type 2 Diabetes
10.8 Conclusion
References
Chapter 11. DNA Methylation in Metabolic Diseases
11.1 Introduction
11.2 Obesity
11.3 Type 2 Diabetes
11.4 Epigenome-Metabolism Crosstalk
11.5 Conclusion
References
Chapter 12. DNA Methylation in Pituitary Diseases
12.1 Introduction
12.2 Hypothalamo-Pituitary Axis
12.3 Pituitary Development
12.4 Pituitary Adenoma
12.5 Pro-Opiomelanocortin Gene
12.6 Prolactin and Growth Hormone
12.7 Gonadotropins (Luteinizing Hormone, Follicle Stimulating Hormone)
12.8 Thyroid Stimulating Hormone
12.9 Arginine Vasopressin and Atrial Natriuretic Peptide
12.10 Conclusion
References
Chapter 13. DNA Methylation and Development
13.1 Introduction
13.2 Different Embryonic Lineages
13.3 Mesoderm Development
13.4 Ectoderm Development
13.5 Endoderm Development
13.6 Hematopoietic Stem Cells
13.7 Conclusion
References
Chapter 14. DNA Methylation in Growth Retardation
14.1 Introduction
14.2 Silver-Russell Syndrome
14.3 Beckwith-Wiedemann Syndrome
14.4 Transient Neonatal Diabetes Mellitus
14.5 Pseudohypoparathyroidism Type 1b (PHP1b)
14.6 Prader-Willi and Angelman Syndromes
14.7 Syndromes Mimicking Uniparental Disomy 14 (UPD14)
14.8 Familial Biparental Hydratidiform Mole
14.9 Conclusion
References
Chapter 15. DNA Methylation in Cardiology
15.1 Introduction
15.2 Atherosclerosis
15.3 Arrhythmia
15.4 Ischemic Heart Disease
15.5 Hypertension
15.6 Conclusion
References
Chapter 16. DNA Methylation and Neurology
16.1 Introduction
16.2 Co-Adaptation of Imprinted Genes
16.3 Memory
16.4 Alcoholism
16.5 Drug Addiction
16.6 Schizophrenia
16.7 Conclusion
References
Chapter 17. DNA Methylation in Psychiatric Diseases
17.1 Introduction
17.2 Major Psychosis
17.3 Alzheimer’s Disease
17.4 Autism
17.5 Parkinson’s Disease
17.6 Huntington’s Disease
17.7 Amyotrophic Lateral Sclerosis
17.8 Conclusion
References
Chapter 18. DNA Methylation in Cellular Mechanisms of Neurodegeneration
18.1 Introduction
18.2 Protein Misfolding
18.3 Protein Degradation
18.4 Membrane Damage
18.5 Mitochondrial Dysfunction
18.6 Axonal Transport
18.7 Programmed Cell Death
18.8 Early Life Experiences
18.9 Conclusion
References
Chapter 19. DNA Methylation and Autoimmunity
19.1 Introduction
19.2 Environmental Factors
19.3 Changes in DNA Methylation
19.4 Conclusion
References
Chapter 20. DNA Methylation in Lymphocyte Development
20.1 Introduction
20.2 Hematopoietic Cells
20.3 T-cell Subpopulations
20.4 T-cell Functions
20.5 B-cell Development
20.6 Infection and Inflammation
20.7 Tumor Clearance
20.8 Environmental Factors and Autoimmunity
20.9 Conclusion
References
Chapter 21. DNA Methylation in Stem Cell Diseases
21.1 Introduction
21.2 Stem Cell Differentiation
21.3 Induced Pluripotent Stem Cells
21.4 Environmental Factors and Aging
21.5 Disruption of Differentiation and Development
21.6 Conclusion and Outlook
References
Chapter 22. DNA Methylation and Rheumatology
22.1 Introduction
22.2 Systemic Lupus Erythematosus
22.3 Systemic Sclerosis
22.4 Osteoarthritis
22.5 Rheumatoid Arthritis
22.6 Juvenile Rheumatoid Arthritis
22.7 Dermatomyositis
22.8 Hypermobility Syndromes
22.9 Conclusion
References
Chapter 23. DNA Methylation in Synovial Fibroblasts
23.1 Introduction
23.2 Endogenous Retroviruses
23.3 DNA Hypomethylation
23.4 DNA Methyltransferase 1
23.5 S-Adenosylmethionine and Adenosylhomocysteine
23.6 Recycling Pathway of Polyamines
23.7 Differential Methylation of Specific Promoters
23.8 MicroRNAs Interfering with DNA Methylation
23.9 Conclusion
References
Chapter 24. DNA Methylation in Osteoporosis
24.1 Introduction
24.2 Early Development
24.3 Osteoblast Differentiation
24.4 Variations in the Response to Vitamin D
24.5 Conclusion
References
Chapter 25. Epigenetic Therapies
25.1 Introduction
25.2 Demethylating Agents
25.3 Cancer Stem Cells – Targeted Therapies
25.4 Methyl Donors
25.5 Polyamine Recycling Inhibitors
25.6 Conclusion
References
Chapter 26. Demethylating Agents
26.1 Introduction
26.2 Mechanism of Action
26.3 New Drug Development
26.4 Combination Therapies
26.5 Stem Cell Differentiation
26.6 Induction of Autoimmunity
26.7 Conclusion
References
Chapter 27. Methyl Donors
27.1 Introduction
27.2 L-Methionine
27.3 Betaine
27.4 S-Adenosylmethionine
27.5 Methionine Metabolism
27.6 Polyamine Metabolism
27.7 Conclusion
References
Chapter 28. Methylome Analysis of Complex Diseases
28.1 Introduction
28.2 Global DNA Methylation Analysis
28.3 Gene-Specific Methylation Analysis
28.4 Methylome-Wide Analysis
28.5 Sequencing Approaches
28.6 Conclusion
References
Chapter 29. Methylome Analysis in Cancer
29.1 Introduction
29.2 Bisulfite-Based Methods
29.3 Non-Bisulfite Methods
29.4 Methylated DNA Binding Column
29.5 Combination with MeDiP-seq or RRBS
29.6 DNA Methylation in Formalin-Fixed Paraffin-Embedded Tissues
29.7 Conclusion
References
Chapter 30. Methylome Analysis in Non-Neoplastic Disease
30.1 Introduction
30.2 Environmental Factors
30.3 Cardiovascular Diseases
30.4 Inflammatory Skin Diseases
30.5 Asthma
30.6 Inflammatory Bowel Disease
30.7 Rheumatic Diseases
30.8 Metabolic Diseases
30.9 Neurodegenerative Diseases
30.10 Psychiatric Disorders
30.11 Neurological Disorders
30.12 Conclusion
References
Chapter 31. Outlook
Concluding Thoughts
References
Glossary
Index
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