Essential Pharmacokinetics A Primer for Pharmaceutical Scientist 1st edition by Thorsteinn Loftsson ISBN 0128014113 9780128014110
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ISBN 10: 0128014113
ISBN 13: 9780128014110
Author: Thorsteinn Loftsson
Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.
- Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products
- Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes
- Illustrates how to write and evaluate drug registration files
Essential Pharmacokinetics A Primer for Pharmaceutical Scientist 1st Table of contents:
Chapter 1. Introduction
1.1 Some Basic Concepts
1.2 Pharmacokinetic Models
1.3 Population Pharmacokinetics
References
Chapter 2. Basic Concepts of Pharmacokinetics
2.1 One-Compartment Open Model
2.2 Two-Compartment Open Model
2.3 Three-Compartment Open Model
2.4 Pharmacokinetics of Drug Absorption
2.5 Bioavailability
2.6 Drug Distribution, Protein Binding, and Clearance
2.7 Multiple-Dose Regimens
2.8 Nonlinear Pharmacokinetics
2.9 Drug Metabolism
2.10 Drug Permeation Through Biomembranes and Drug Transporters
References
Chapter 3. Physicochemical Properties and Pharmacokinetics
3.1 Lipinski’s Rule of Five
3.2 The Biopharmaceutics Classification System
3.3 The Biopharmaceutics Drug Disposition Classification System
3.4 Metabolizability, Soft Drugs, and Prodrugs
3.5 Pharmacokinetics of Excipients
References
Chapter 4. Drug Pharmacokinetics After Alternative Routes of Administration
4.1 Fentanyl Transdermal Patch
4.2 Estradiol Sublingual Tablets
4.3 Diazepam Suppositories
4.4 Midazolam Nasal Spray
4.5 Pulmonary Delivery (Inhalation) and Subcutaneous Injection of Insulin
4.6 Topical Delivery of Dexamethasone to the Eye
References
Chapter 5. Pharmacologic Response and Drug Dosage Adjustments
5.1 Therapeutic Drug Monitoring
5.2 Dosage Adjustments
5.3 Pharmacodynamics
Chapter 6. The Effect of Food and Excipients on Drug Pharmacokinetics
References
Chapter 7. Practice Problems
7.1
7.2
7.3
7.4
7.5
7.6
7.7
7.8
7.9
7.10
7.11
7.12
7.13
7.14
7.15
7.16
7.17
References
Appendix I. Answers to Problems in Chapter 7
7.1
7.2
7.3
7.4
7.5
7.6
7.7
7.8
7.9
7.10
7.11
7.12
7.13
7.14
7.15
7.16
7.17
Appendix II. Symbols and Abbreviations
Index
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Tags: Thorsteinn Loftsson, Essential Pharmacokinetics, Pharmaceutical Scientist