Exploring Bioinformatics A ProjectBased Approach 2nd Edition by Caroline Clair – Ebook PDF Instant Download/Delivery: 9781284082012, 1284082016
Full dowload Exploring Bioinformatics 2nd Edition after payment
Product details:
• ISBN 10:1284082016
• ISBN 13:9781284082012
• Author:Caroline Clair
Exploring Bioinformatics
Exploring Bioinformatics A ProjectBased Approach 2nd Table of contents:
Chapter 1 Bioinformatics and Genomic Data: Investigating a Complex Genetic Disease
Understanding the Problem: Parkinson Disease, A Complex Genetic Disorder
Bioinformatics Solutions: Databases and Data Mining
Understanding Genomic Databases
Primary Databases
Metadatabases
Database Searching
Genome Browsers
Chapter Project: Genomic Regions Associated with Parkinson Disease
Web Exploration: Data Mining in the Genome Databases
On Your Own Project: Clues to a Genetic Disease
References and Supplemental Reading
Chapter 2 Computational Manipulation of DNA: Genetic Screening for Disease Alleles
Understanding the Problem: Genetic Screening and the Inheritance of Cystic Fibrosis
Bioinformatics Solutions: Computational Approaches to Genes
Understanding the Algorithm: Decoding DNA
A DNA Manipulation Algorithm
A Transcription Algorithm
A Translation Algorithm
A Mutation Detection Algorithm
Chapter Project: Genetic Screening for Carriers of CF Mutations
Web Exploration
Guided Programming Project: Working with DNA and Protein Strings
On Your Own Project: Identifying Insertions and Deletions
References and Supplemental Reading
Chapter 3 Sequence Alignment: Investigating an Influenza Outbreak
Understanding the Problem: The 2009 H1N1 Influenza Pandemic
Bioinformatics Solutions: Sequence Alignment and Sequence Comparison
Understanding the Algorithm: Global Alignment
Optimal Alignment and Scoring
Needleman-Wunsch Algorithm
Generating the Alignment
Chapter Project: Investigation of Influenza Virus Strains
Web Exploration
Guided Programming Project: The Needleman-Wunsch Global Alignment Algorithm
On Your Own Project: A Local Alignment Algorithm
References and Supplemental Reading
Chapter 4 Database Searching and Multiple Alignment: Investigating Antibiotic Resistance
Understanding the Problem: Antibiotic Resistance
Bioinformatics Solutions: Advanced Sequence Comparison Algorithms
Understanding the Algorithm: Database Searching and Multiple Alignment
BLAST: A Heuristic Approach to Database Searching
ClustalW: Multiple Sequence Alignment
Chapter Project: Horizontal Gene Transfer of Antibiotic Resistance
Searching for Erythromycin Resistance Genes with BLAST
Multiple Sequence Alignment with ClustalW
References and Supplemental Reading
Chapter 5 Substitution Matrices and Protein Alignments: Virulence Factors in E. coli
Understanding the Problem: Virulence Factors in E. coli Outbreaks
Bioinformatics Solutions: Protein Alignment and Clues to Function
Understanding the Algorithm: Protein Alignment and Substitution Matrices
Substitution Matrices
Protein Alignment Algorithm: Scoring with the Substitution Matrix
Chapter Project: Using Protein Alignment to Investigate Functions of Virulence Factors
Web Exploration
Guided Programming Project: Using a Substitution Matrix in a Protein Alignment Program
On Your Own Project: Building Your Own Substitution Matrix
References and Supplemental Reading
Chapter 6 Distance Measurement in Molecular Phylogenetics: Evolution of Mammals
Understanding the Problem: Mammalian Evolution
Bioinformatics Solutions: Molecular Phylogenetics and Distance Measurement
Understanding the Algorithm: Measuring Distance
Jukes-Cantor Model
Kimura’s Two-Parameter Substitution Model
Tamura’s Three-Parameter Model
Other Models
Chapter Project: Evolution of the Whale
Web Exploration: Evolution of Marine Mammals
Guided Programming Project: Using Distance Metrics to Measure Similarity
On Your Own Project: Alignment and Evolutionary Distance
References and Supplemental Reading
Chapter 7 Tree-Building in Molecular Phylogenetics: Three Domains of Life
Understanding the Problem: Rooting the Tree
Bioinformatics Solutions: Tree-Building
Understanding the Algorithm: Clustering Algorithms
Chapter Project: Placing the Archaea in the Tree of Life
Web Exploration: Molecular Clocks and the Archaea
Guided Programming Project: Phylogenetic Trees Using Agglomerative Clustering
On Your Own Project: The Neighbor-Joining Method
References and Supplemental Reading
Chapter 8 DNA Sequencing: Identification of Novel Viral Pathogens
Understanding the Problem: Deep Sequencing of Clinical Samples
Bioinformatics Solutions: Assembly and Mapping of Short Sequence Reads
Understanding the Algorithm: Determining Overlap in Sequence Assembly
Chapter Project: Identifying Viruses Through Metagenomic Analysis of Clinical Samples
Web Exploration: Analysis of Virus Sequences in the Human Metagenome
Guided Programming Project: Sequencing and Assembly
On Your Own Project: A Mini-Assembly Program
References and Supplemental Reading
Chapter 9 Sequence-Based Gene Prediction: Annotation of a Resistance Plasmid
Understanding the Problem: Gene Discovery
Bioinformatics Solutions: Gene Prediction
Understanding the Algorithm: Pattern Matching in Sequence-Based Gene Prediction
Chapter Project: Gene Discovery in a Resistance Plasmid
Web Exploration: Prokaryotic Gene Prediction and Annotation
Guided Programming Project: Pattern Matching for Sequence-Based Gene Prediction
On Your Own Project: Sequence-Based Gene Discovery in Eukaryotes
References and Supplemental Reading
Chapter 10 Advanced Gene Prediction: Identification of an Influenza Resistance Gene
Understanding the Problem: Exon Prediction
Bioinformatics Solutions: Content- and Probability-Based Gene Prediction
Understanding the Algorithm: Codon Usage, Frequency Matching, HMMs, and Neural Networks
Using Codon Frequencies in Gene Prediction
Prediction of CpG Islands
HMMs for Gene Prediction
Neural Network Modeling
Chapter Project: Identifying an Influenza Resistance Gene
Web Exploration: Finding Genes in a Eukaryotic Genome Sequence
Guided Programming Project: Predicting CpG Islands
On Your Own Project: Hidden Markov Modeling in Gene Prediction
References and Supplemental Reading
Chapter 11 Protein Structure Prediction and Analysis: Rational Drug Design
Understanding the Problem: Structure Prediction
Bioinformatics Solutions: Predicting and Modeling Protein Structure
Understanding the Algorithm: The Chou-Fasman Algorithm for Secondary Structure Prediction
Chapter Project: Protein Structure Prediction
Web Exploration: Protein Structure Modeling and Drug Design
Guided Programming Project: Structure Prediction with the Chou-Fasman Algorithm
On Your Own Project: A Complete Chou-Fasman Program
References and Supplemental Reading
Chapter 12 Nucleic Acid Structure Prediction: Polymerase Chain Reaction and RNA Interference
Understanding the Problem: Nucleic Acid Structure Prediction
Bioinformatics Solutions: Secondary Structure Prediction
Understanding the Algorithm: The Nussinov-Jacobson Algorithm
Chapter Project: Nucleic Acid Structure Prediction
Web Exploration: Applications of Nucleic Acid Structure Prediction
Guided Programming Project: Structure Prediction with the Nussinov-Jacobson Algorithm
On Your Own Project: PCR Primer Analysis with Nussinov-Jacobson
References and Supplemental Reading
Appendix Introduction to Programming
Programming Basics
Five Main Programming Constructs
Assignment Statements
Input Statements
Output Statements
Decision Statements
Loop Statements
Data Structures
Arrays
Hash Tables
Functions
A Sample Program
Glossary
Index
People also search for Exploring Bioinformatics A ProjectBased Approach 2nd:
exploring bioinformatics caroline
exploring bioinformatics
exploring bioinformatics a project-based approach
an introduction to bioinformatics algorithms
an introduction to bioinformatics algorithms pdf