Filaggrin Basic Science Epidemiology Clinical Aspects and Management 1st edition by Springer 9783642543784 3642543782

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ISBN 10: 3642543782

ISBN 13: 9783642543784

Author: Springer

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

 

 

Filaggrin Basic Science Epidemiology Clinical Aspects and Management 1st Table of contents: 

1. Basic Science

1. Function of Filaggrin and Its Metabolites

2. Morphology of Filaggrin-Depleted Epidermis

3. Stratum Corneum Lipids and Filaggrin

4. Inflammatory-Driven Depletion of Filaggrin Proteins

5. Immune Activity and Vitamin D

6. Filaggrin-2

2. Identification and Study Methods

7. Animal Models

8. In Vitro Models of Filaggrin-Associated Diseases

9. Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics

10. Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy

11. Filaggrin Genotyping

3. Epidemiology and Environmental Exposures

12. Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective

13. Filaggrin Gene Mutations in Asian Races

14. Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals

4. Filaggrin and Atopic Disease

15. Filaggrin Mutations and the Atopic March

16. Atopic Dermatitis

17. Asthma

18. Filaggrin Mutations, Skin Barrier Dysfunction, and Sensitization in Allergic Rhinitis

19. Filaggrin and Non-cutaneous Disease: Food Allergy

20. Filaggrin in Canine Skin

5. Filaggrin and Cutaneous Disease

21. Ichthyosis Vulgaris and Other Disorders of Cornification

22. Xerosis Means “Dry Skin”: Mechanisms, Skin Conditions, and Its Management

23. Allergic Contact Dermatitis

24. Irritant Contact Dermatitis

25. Hand Eczema

26. Filaggrin in Psoriasis

27. Filaggrin and Skin Infections

28. Atopic Dermatitis and Skin Cancer

29. Filaggrin Gene Mutations: A Clinician’s Perspective

6. Filaggrin and Non-cutaneous Disease

30. Filaggrin, the Skin Barrier, and Diabetes

31. The Eye and Filaggrin

32. Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract

33. Filaggrin, Human Papillomavirus, and the Cervix

34. Antibodies Against Citrullinated Proteins and Filaggrin

35. Filaggrin and the Oral Mucosa

7. Management

36. Therapeutics and Other Interventions

 

 

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