Fish Physiology Zebrafish Volume 29 1st edition by Steve Perry, Marc Ekker, Anthony Farrell, Colin Brauner ISBN ‎ 0123749832 ‎ 978-0123749833

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ISBN 10:‎ 0123749832
ISBN 13: ‎ 978-0123749833
Author: Steve Perry, Marc Ekker, Anthony Farrell, Colin Brauner

This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a “fully” sequenced genome, ii) rapid (~3 month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics to assess gene function. Gene knockdown in embryos and the production of transgenic strains are now standard techniques being used to assess physiology. This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists and developmental biologists.

• Integrates and synthesizes the biology of the zebrafish under one cover
• Features contributions from the leading researchers in their fields
• Reaches a wider audience of researchers and biologists with its broad inclusion of subjects relating to zebrafish physiology

Fish Physiology Zebrafish Volume 29 1st Table of contents:

Chapter 1. Genetic Tools

1. Introduction

2. Forward Genetics: From Large Screens to Targeted Screens

3. Reverse Genetics: Morpholino Knockdowns

4. Reverse Genetics: TILLING

5. Reverse Genetics: Zinc Finger Nucleases

6. Gain of Function: Targeted Misexpression of Genes

7. Genetic Ablation of Specific Cell Population

8. Concluding Remarks

Chapter 2. Organization and Physiology of the Zebrafish Nervous System

1. Introduction

2. Nervous System Development and General Organization

3. General Organization of the Zebrafish Nervous System, Subdivisions and Main Functions

4. The Peripheral Nervous System

5. Sensory Systems

6. Motor Systems and Integrative Centers

7. Monoaminergic and Related Regulatory Systems

8. Emotions and Cognition

9. Nervous System Plasticity

Chapter 3. Zebrafish Vision: Structure and Function of the Zebrafish Visual System

1. Visual Ecology

2. Structure of the Visual System

3. Retinal Projections

4. Optic Tectum

5. Visual Behavior

6. Complex Visual Behavior

7. Concluding Remarks

Chapter 4. The Zebrafish Inner Ear

1. Introduction

2. Development of the Inner Ear

3. Generation and Homeostasis of Endolymph in the Zebrafish Inner Ear

4. Zebrafish Sensory Hair Cells

5. Mechanotransduction

6. Neural Activity

7. Otoliths

8. Adult Hearing

9. Concluding Remarks

Chapter 5. Endocrinology of Zebrafish: A Small Fish with a Large Gene Pool

1. Introduction

2. Reproduction

3. Stress: The Cortisol Stress Axis

4. Growth

5. Thyroidal Regulation

6. Energy Homeostasis: Food Intake and Metabolism

7. Osmoregulation

8. Summary

Chapter 6. Developmental Physiology of the Zebrafish Cardiovascular System

1. Cardiovascular Disease: Models Wanted

2. Current Models for Cardiovascular System Studies

3. Filling a Niche with Zebrafish

4. Unique Advantages of the Zebrafish for Cardiovascular Studies

5. Vertebrate Cardiac Development

6. Origin and Lineage of Cells in the Cardiovascular System

7. Zebrafish Genetics and Development of the Cardiovascular System

8. Genetic Infrastructure and Tools for Zebrafish Studies

9. Zebrafish Cardiovascular Mutants

10. Mutants Affecting Rate, Rhythm and Contractile Properties of the Heart

11. Relationship Between Cardiovascular Function and Form

12. Endothelial Cell Specification and Differentiation

13. Specification of Artery and Vein

14. Cell Migration of Angioblasts and Vascular Patterning

15. Angiogenesis of the Intersegmental Vessels

16. Lumenization of Vessels

17. Vascular Stabilization, Mural Cells, and Extracellular Matrix

18. Angiogenesis of Organs

19. Chemical Biology Approaches to Study Cardiovascular Biology

20. Forces that Influence Cardiovascular Development

21. Endothelial Cell Survival

22. Zebrafish Models for Vascular Anomalies

23. Tools for the Study of Cardiovascular Physiology

24. Vessel Regeneration

25. Cardiac Regeneration

26. Summary

Chapter 7. Respiration

1. Introduction

2. The Principles of Gas Exchange

3. The Site of Gas Exchange

4. Convective Transport

5. Metabolic Activity

6. Hypoxic Effects

7. Temperature Effects

8. Future Perspectives

Chapter 8. Ionic and Acid–Base Regulation

1. Introduction

2. Identification of Ionocytes in Skin/gills

3. Sodium Uptake and Acid Secretion by Skin/gills

4. Chloride Uptake and Base Excretion

5. Calcium Uptake

6. Ammonia Excretion

7. Differentiation and Functional Regulation of Ionocytes

8. Neuroendocrine Control of Ion Uptake and Acid–Base Regulation

9. Renal Ionic and Acid–Base Regulation

10. Conclusions and Perspectives

Chapter 9. The Zebrafish as a Model for Human Disease

1. Introduction

2. Cancer

3. Hematopoietic Disorders

4. Cardiovascular Diseases

5. Chemical Screening in Zebrafish

6. Summary

Chapter 10. Perspectives on Zebrafish as a Model in Environmental Toxicology

1. Introduction

2. Current Issues in Environmental Toxicology

3. The Zebrafish Toxicology Landscape: Emergence of a New Model

4. Molecular Environmental Toxicology: The Defensome Concept

5. Advances and Insights with Zebrafish

6. Toxicity and Environmental Assessment with Zebrafish

7. Areas of Looming Significance and Promising Approaches

8. Some Conclusions

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Tags: Steve Perry, Marc Ekker, Anthony Farrell, Colin Brauner, Fish Physiology