Fundamentals of Clinical Trials 4th Edition by Lawrence Friedman, Curt Furberg, David DeMets – Ebook PDF Instant Download/Delivery: B008BA6JEC, 978-1441915863
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ISBN 10: B008BA6JEC
ISBN 13: 978-1441915863
Author: Lawrence Friedman, Curt Furberg, David DeMets
The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2–21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues.
Fundamentals of Clinical Trials 4th Table of contents:
1. Introduction to Clinical Trials
2. Ethical Issues
3. What Is the Question?
4. Study Population
5. Basic Study Design
6. The Randomization Process
7. Blindness
8. Sample Size
9. Baseline Assessment
10. Recruitment of Study Participants
11. Data Collection and Quality Control
12. Assessing and Reporting Adverse Events
13. Assessment of Health-Related Quality of Life
14. Participant Adherence
15. Survival Analysis
16. Monitoring Response Variables
17. Issues in Data Analysis
18. Closeout
19. Reporting and Interpreting of Results
20. Multicenter Trials
Backmatter
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Tags: Lawrence Friedman, Curt Furberg, David DeMets, Clinical Trials