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Holes 1st edition by Louis Sachar 9780307798367 0307798364

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• ISBN 10:0307798364

• ISBN 13:9780307798367

• Author:Louis Sachar

Holes

This groundbreaking classic is now available in a special anniversary edition with bonus content. Winner of the Newbery Medal as well as the National Book Award, HOLES is a New York Times bestseller and one of the strongest-selling middle-grade books to ever hit shelves! Stanley Yelnats is under a curse. A curse that began with his no-good-dirty-rotten-pig-stealing-great-great-grandfather and has since followed generations of Yelnatses. Now Stanley has been unjustly sent to a boys’ detention center, Camp Green Lake, where the boys build character by spending all day, every day digging holes exactly five feet wide and five feet deep. There is no lake at Camp Green Lake. But there are an awful lot of holes. It doesn’t take long for Stanley to realize there’s more than character improvement going on at Camp Green Lake. The boys are digging holes because the warden is looking for something. But what could be buried under a dried-up lake? Stanley tries to dig up the truth in this inventive and darkly humorous tale of crime and punishment —and redemption. Special anniversary edition bonus content includes: A New Note From the Author!; “Ten Things You May Not Know About HOLES” by Louis Sachar; and more!

Holes 1st Table of contents:

CHAPTER 1
1.1: Ultrasonography and Magnetic Resonance Imaging: A Tale of Two 
Patients 6
CHAPTER 2
2.1: Radioactive Isotopes Reveal Physiology 54
2.2: Ionizing Radiation: From the Cold War to Yucca Mountain 56
2.3: CT Scanning and PET Imaging 70
b
3.1: Faulty Ion Channels Cause Disease 81
3.2: The Blood-Brain Barrier 82
3.3: Disease at the Organelle Level 88
3.1: Therapeutic Stem Cells 110
CHAPTER 4 
4.1: Overriding a Block in Glycolysis 123
4.2: Phenylketonuria 138
4.1: DNA Profiling Reveals History 129
4.2: Nucleic Acid Amplification 130
CHAPTER 5 
5.1: A New View of the Body?s Glue: The Extracellular Matrix 154
5.2: Abnormalities of Collagen 156
5.1: Tissue Engineering 166
CHAPTER 6 
6.1: Skin Cancer 175
6.2: Hair Loss 178
6.3: Acne 181
6.4: Elevated Body Temperature 183
CHAPTER 7 
7.1: Fractures 202
7.2: Osteoporosis 205
7.3: Disorders of the Vertebral Column 225
CHAPTER 8 
8.1: Replacing Joints 277
8.2: Joint Disorders 280
CHAPTER 9 
9.1: Myasthenia Gravis 292
9.2: Use and Disuse of Skeletal Muscles 302
9.3: TMJ Syndrome 311
CHAPTER 10 
10.1: Migraine 358
10.2: Multiple Sclerosis 363
10.3: Factors Affecting Impulse Conduction 375
10.4: Opiates in the Human Body 378
10.5: Drug Addiction 379
CHAPTER 11 
11.1: Cerebrospinal Fluid Pressure 390
 11.2: Uses of Reflexes 396
 11.3: Spinal Cord Injuries 400
 11.4: Cerebral Injuries and Abnormalities 408
 11.5: Parkinson Disease 410
 11.6: Brain Waves 417
 11.7: Spinal Nerve Injuries 428
Chapter 12 
  12.1: Treating Pain 449
 12.2: Mixed-up Senses?Synesthesia 450
 12.3: Smell and Taste Disorders 455
 12.4: Getting a Cochlear Implant 462
 12.5: Hearing Loss 464
 12.6: Refraction Disorders 478
Chapter 13 
 13.1: Using Hormones to Improve Athletic Performance 496
 13.2: Growth Hormone Ups and Downs 503
 13.3: Disorders of the Adrenal Cortex 516
 13.4: Diabetes Mellitus 519
CHAPTER 14 
 14.1: King George III and Porphyria Variegata 536
 14.2: Leukemia 542
 14.3: The Return of the Medicinal Leech 551
 14.4: Living with Hemophilia 552
CHAPTER 15 
 15.1: Arrhythmias 580
 15.2: Blood Vessel Disorders 589
 15.3: Measurement of Arterial Blood Pressure 592
 15.4: Space Medicine 594
 15.5: Hypertension 597
 15.6: Exercise and the Cardiovascular System 599
 15.7: Molecular Causes of Cardiovascular Disease 618
 15.8: Coronary Artery Disease 620
 15.1: Replacing the Heart 574
 15.2: Altering Angiogenesis 584
CHAPTER 16 
 16.1: Immunity Breakdown: AIDS 656
 16.1: Immunotherapy 646
 16.2: -Conquering Inherited Immune Deficiency?Children Who Made 
Medical History 650
CHAPTER 17
 17.1: Dental Caries 673
 17.2: Oh, My Aching Stomach! 683
 17.3: Hepatitis 691
 17.4: Gallbladder Disease 692
 17.5: Disorders of the Large Intestine 706
 17.6: Replacing the Liver 690
CHAPTER 18 
 18.1: Obesity 726
 18.2: Dietary Supplements?Proceed with Caution 741
 18.3: Nutrition and the Athlete 744
CHAPTER 19
19.1: The Effects of Cigarette Smoking on the Respiratory 
System 756
 19.2: Lung Irritants 767
 19.3: -Respiratory Disorders That Decrease Ventilation: Bronchial 
Asthma and Emphysema 773
 19.4: Exercise and Breathing 778
 19.5: Effects of High Altitude 781
 19.6: -Disorders That Impair Gas Exchange: Pneumonia, 
Tuberculosis, and Adult Respiratory Distress Syndrome 782
CHAPTER 20
 20.1: Chronic Kidney Failure 796
 20.2: Glomerulonephritis 800
 20.3: The Nephrotic Syndrome 810
 20.4: Urinalysis: Clues to Health 820
CHAPTER 21
 21.1: Water Balance Disorders 832
 21.2: Sodium and Potassium Imbalances 837
 21.3: Acid-Base Imbalances 842
CHAPTER 22
 22.1: Prostate Enlargement 858
 22.2: Male Infertility 860
 22.3: Female Infertility 879
 22.4: Treating Breast Cancer 882
CHAPTER 23
 23.1: Assisted Reproductive Technologies 896
 23.2: Preimplantation Genetic Diagnosis 900
 23.1: Some Causes of Birth Defects 912
 23.2: Joined for Life 921
 23.3: Human Milk?The Perfect Food for Human Babies 925
 23.4: Old Before Their Time 932
 CHAPTER 24
 24.1: It?s All in the Genes 942
 24.2: Down Syndrome 954
 24.3: Targets of Gene Therapy 958

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