How to Scale Up a Wet Granulation End Point Scientifically 1st edition by Michael Levin – Ebook PDF Instant Download/Delivery: 0128035603, 9780128035603
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Product details:
ISBN 10: 0128035603
ISBN 13: 9780128035603
Author: Michael Levin
How to Scale-Up a Wet Granulation End Point Scientifically
provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point.
Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process.
How to Scale Up a Wet Granulation End Point Scientifically 1st Table of contents:
- Chapter 1. Scale-Up Basics
- Abstract
- Chapter 2. Dimensional Analysis
- Abstract
- 2.1 Theory of Modeling and Principle of Similitude
- 2.2 Dimensionless Numbers
- 2.3 Π-Theorem
- 2.4 Relevance List
- 2.5 Dimensional Matrix
- 2.6 Examples
- 2.7 Comparison of Attainable Froude Numbers
- Chapter 3. Wet Granulation
- Abstract
- 3.1 Basics
- 3.2 What Can be Measured on a Mixer-Granulator?
- 3.3 End-Point Determination and Scale-Up: Semi-Empirical Methods
- Chapter 4. Recommended Procedures: Case Studies
- Abstract
- 4.1 Case Study I: Leuenberger et al. (1979, 1983)
- 4.2 Case Study II: Landin et al. (1996)
- 4.3 Case Study III: Faure et al. (1998)
- 4.4 Case Study IV: Landin et al. (1999)
- 4.5 Case Study V: Faure et al. (1999)
- 4.6 Case Study VI: Hutin et al. (2004)
- 4.7 Case Study VII: André et al. (2012)
- Chapter 5. Practical Considerations for End-Point Scale-Up
- Abstract
- 5.1 How to Define and Determine the End Point
- 5.2 How to Reproduce the End Point
- 5.3 How to Scale-Up the End Point
- Chapter 6. List of Symbols and Dimensions
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