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Management of Soft Tissue Sarcoma 2nd Edition by Murray Brennan, Cristina Antonescu, Kaled Alektiar, Robert Maki ISBN 3319419048 978-3319419046

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ISBN 10: 3319419048
ISBN 13: 978-3319419046
Author: Murray Brennan, Cristina Antonescu, Kaled Alektiar, Robert Maki 

Management of Soft Tissue Sarcoma, 2nd Edition provides the most comprehensive analysis of demographics and natural history currently available for these lesions, based on the authors’ experience with over 10,000 patients. Sections regarding radiation therapy not found in the previous text have been expanded, as have updates on molecular characteristics of sarcomas and chemotherapy studies published since the prior edition. Clinical and molecular diagnoses are addressed, and tumor histopathology is employed as the basis of treatment recommendations including surgery, radiation and systemic therapy. This is the first book to provide specific chemotherapy opinions for every sarcoma subtype. Written by four world-renowned experts, this book gives a practical, up-to-date approach to managing the many subtypes of adult soft tissue sarcoma.
Reviews from the first edition:
“This is an impressive book. Written by a surgeon, a pathologist and an oncologist, the book draws heavily on the Memorial Sloan-Kettering Cancer Center soft tissue sarcoma (STS) database. … it is a book that should be in the library of any sarcoma unit and will appeal to the sub-specialist in Orthopaedic Oncology.” (Robert U. Ashford, European Journal of Orthopaedic Surgery & Traumatology, Vol. 24, 2014)
“The book is laid out in 27 chapters, with an impressive inclusion of a wide array of sarcoma histology. One of the real strengths of the book is the quality and number of images, figures, tables, and graphs. … The overall outline of the text is well done. … This book is a unique and important addition to the sarcoma literature. … this edtion should find itself on every medical oncologist’s bookshelf … .” (Larry C. Daugherty and Sanjay P. Bagaria, Journal of Radiation Oncology, Vol. 3, 2014)

Management of Soft Tissue Sarcoma 2nd Table of contents:

Part I: Introduction

Chapter 1: General Description

1.1 Introduction

1.2 Incidence and Prevalence

1.3 Predisposing and Genetic Factors

References

Chapter 2: Natural History: Importance of Size, Site, Histopathology

2.1 Natural History

2.2 Influence of Site

2.3 Staging

2.4 Staging of Retroperitoneal and Visceral Sarcoma

2.5 Prognostic Factors for Extremity and Superficial Soft Tissue Sarcoma

2.6 Disease-Specific Survival

2.7 Prognostic Factors for Survival Following Local Recurrence of Extremity Sarcoma

2.8 AJCC Staging

2.9 Prognostic Factors—Nomograms

References

Chapter 3: General Statement as to Efficacy of Surgery, Chemotherapy, Radiation Therapy, and Imm

3.1 Extent of Primary Surgery

3.2 Surgical Treatment of Local Recurrence

3.3 Diagnostic Imaging

3.4 Surgery for Metastatic Disease

3.4.1 Pulmonary Metastasis

3.4.1.1 The Role of Pulmonary Metastatic Resection

3.4.2 Surgery and Management of Sarcoma Liver Metastasis

3.5 Radiation Therapy

3.5.1 Adjuvant Radiation Therapy

3.5.2 Types of Radiation Therapy

3.5.3 Dose/Volume of Radiation Therapy

3.5.4 Morbidity of Adjuvant Radiation Therapy

3.5.5 Definitive Radiation Therapy

3.6 Adjuvant and Neoadjuvant Chemotherapy for Soft Tissue Sarcomas

3.6.1 Sarcomas More Common in Adults

3.6.2 Larger Randomized Studies

3.6.3 Selected Meta-analyses of Randomized Trials of Adjuvant Chemotherapy

3.6.4 Adjuvant Therapy for GIST

3.6.5 Sarcomas More Common in the Pediatric Setting

3.7 Brief Comments Regarding Chemotherapy for Metastatic Soft Tissue Sarcoma

3.8 Special Techniques for Primary and Locally Recurrent Disease

3.8.1 Intra-arterial Chemotherapy

3.8.2 Limb Perfusion and Hyperthermia

3.9 Immunotherapy for Sarcomas

References

Part II: Management by Histopathology

Chapter 4: Gastrointestinal Stromal Tumors

4.1 Imaging

4.2 Familial GIST

4.3 Natural History

4.4 Diagnosis, Molecular Pathology

4.5 Treatment

4.6 Adjuvant Imatinib for Primary GIST

4.7 Neoadjuvant Therapy for Primary Disease Not Amenable to Surgery

4.8 Treatment of Recurrence

4.9 First line Imatinib For Metastatic GIST

4.10 Dose Intensity Over Time

4.11 Imatinib Pharmacokinetics

4.12 Second Line Sunitinib for Imatinib-Resistant Metastatic GIST

4.13 Regorafenib in Third Line for Metastatic GIST

4.14 Other Tyrosine Kinase Inhibitors for Metastatic GIST Failing Imatinib and Sunitinib

4.15 Newer Agents for GIST

References

Chapter 5: Liposarcoma

5.1 Imaging

5.2 Diagnosis

5.3 Treatment

5.4 Radiation Therapy for Liposarcoma

5.5 Systemic Therapy: General Considerations

5.6 Adjuvant Therapy

5.7 Treatment of Metastatic Disease

5.8 Outcomes

5.9 Outcome Following Metastasis

References

Chapter 6: Leiomyosarcoma

6.1 Imaging

6.2 Diagnosis, Molecular Pathology

6.3 Primary Treatment

6.4 Radiation Therapy

6.5 Systemic Therapy

6.5.1 Adjuvant Chemotherapy for Leiomyosarcoma

6.6 Outcomes After Primary Therapy

6.7 Patterns of Recurrence

6.7.1 Treatment of Recurrence

6.8 Metastatic Disease

References

Chapter 7: Undifferentiated Pleomorphic Sarcoma (UPS) (Malignant Fibrous Histiocytoma (MFH) and Myx

7.1 Imaging

7.2 Diagnosis, Molecular Pathology

7.3 Natural History

7.4 Treatment

7.5 Radiation Therapy

7.6 Metastatic Disease

7.7 Adjuvant Chemotherapy

7.8 Outcome

References

Chapter 8: Synovial Sarcoma

8.1 Imaging

8.2 Diagnosis, Molecular Pathology

8.3 Treatment

8.4 Radiation Therapy

8.5 Chemotherapy

8.6 Treatment of Recurrence

8.6.1 Local Recurrence

8.7 Systemic Treatment

8.8 Outcome

References

Chapter 9: Malignant Peripheral Nerve Sheath Tumor (MPNST) and Triton Tumor

9.1 Presentation

9.2 Imaging

9.3 Diagnosis, Pathology

9.4 Neurofibromatosis Type 1 and Outcome

9.5 Treatment

9.6 Radiation Therapy

9.7 Chemotherapy for MPNST

9.8 Outcome

References

Chapter 10: Desmoid Tumor/Deep-Seated Fibromatosis (Desmoid-Type Fibromatosis)

10.1 Clinical Presentation

10.2 Imaging

10.3 Diagnosis, Molecular Pathology

10.4 Natural History

10.5 Treatment

10.6 Treatment of Recurrence

10.7 Systemic Therapy

10.8 Treatment by Observation

10.9 Radiation Therapy

10.10 Patterns of Failure

10.11 Outcome

References

Chapter 11: Solitary Fibrous Tumor/Hemangiopericytoma

11.1 Doege–Potter Syndrome

11.2 Primary Therapy

11.3 Systemic Therapy for Metastatic Disease

11.4 Outcome

References

Chapter 12: Fibrosarcoma and Its Variants

12.1 Outcome

12.2 Dermatofibrosarcoma Protuberans

12.2.1 Outcome

12.3 Low-Grade Fibromyxoid Sarcoma (Also Termed Evans Tumor)

12.3.1 Outcome

12.4 Sclerosing Epithelioid Fibrosarcoma

12.5 Inflammatory Myofibroblastic Tumor

12.6 Infantile Fibrosarcoma

12.7 Myxoinflammatory Fibroblastic Sarcoma/Inflammatory Myxohyaline Tumor of Distal Extremities

12.8 Adult-Type Fibrosarcoma

References

Chapter 13: Vascular Sarcomas

13.1 Epithelioid Hemangioendothelioma

13.2 Angiosarcoma/Lymphangiosarcoma

13.3 Outcome

13.4 Kaposi Sarcoma

References

Chapter 14: Epithelioid Sarcoma

14.1 Outcome

References

Chapter 15: Sarcomas More Common in Children

15.1 Soft Tissue Sarcomas More Commonly Observed in Pediatric Patients

15.2 Ewing Sarcoma Family of Tumors

15.3 Demographics

15.4 Primary Therapy

15.5 Adjuvant Chemotherapy

15.6 High-Dose Systemic Therapy for Metastatic Disease

15.7 Standard Cytotoxic Chemotherapy After Disease Relapse

15.8 Investigational Approaches

15.9 Ewing Sarcoma-Like Small Blue Round Cell Tumors

15.10 Rhabdomyosarcoma

15.11 Demographics

15.12 Molecular Biology

15.13 Risk Stratification

15.14 Staging

15.15 Imaging

15.16 Primary Therapy

15.17 Chemotherapy for Metastatic Disease

15.18 Mesenchymal Chondrosarcoma

15.19 Embryonal Sarcoma

References

Chapter 16: Radiation-Induced Sarcoma

References

Chapter 17: Alveolar Soft Part Sarcoma

17.1 Imaging

17.2 Diagnosis, Molecular Pathology

17.3 Primary Treatment

17.4 Treatment of Metastatic Disease

17.5 Outcome

References

Chapter 18: Clear Cell Sarcoma/Melanoma of Soft Parts

18.1 Imaging

18.2 Diagnosis, Molecular Pathology

18.3 Treatment

18.4 Outcome

References

Chapter 19: Desmoplastic Small Round Cell Tumor

19.1 Imaging

19.2 Diagnosis

19.3 Treatment

19.4 Outcome

References

Chapter 20: Extraskeletal Myxoid Chondrosarcoma

20.1 Imaging

20.2 Diagnosis

20.3 Treatment

20.4 Outcome

References

Chapter 21: Other Uterine Sarcomas

21.1 Low Grade Endometrial Stromal Sarcoma

21.1.1 Diagnosis

21.1.2 Treatment

21.1.3 Outcome

21.2 High Grade Endometrial Stromal Sarcoma

21.2.1 Outcome

21.3 Undifferentiated Uterine Sarcoma (UUS)

21.4 PEComas

21.5 Uterine Carcinosarcomas and Other Malignant Mixed Müllerian Tumors

21.6 Outcome

References

Chapter 22: Extraskeletal Osteogenic Sarcoma

22.1 Imaging

22.2 Diagnosis

22.3 Treatment

22.4 Outcome

References

Chapter 23: Sustentacular Tumors of Lymph Tissue

23.1 Follicular Dendritic Cell Tumor and Interdigitating Reticulum Cell Tumor

23.2 True Histiocytic Sarcoma

23.3 Langerhans Cell Tumors

23.4 Outcome

References

Chapter 24: Uncommon/Unique Sites

24.1 Heart and Great Vessels

24.2 Primary Sarcomas of the Breast

24.2.1 Phyllodes Tumor

24.2.1.1 Diagnosis

24.2.1.2 Outcome

24.3 Head and Neck

24.3.1 Treatment

24.4 Primary Sarcomas of the Mediastinum

24.5 Liver

References

Part III: Benign and Less Aggressive Lesions

Chapter 25: Mostly Benign/Rarely Metastasizing

25.1 Ossifying Fibromyxoid Tumor

25.2 Perivascular Epithelioid Cell Tumor (PEComa) and Related Entities, Lymphangioleiomyomatosis, A

25.3 Therapy

25.4 Giant Cell Tumor of Tendon Sheath/Pigmented Villonodular Synovitis

25.5 Myoepithelial Tumors of Soft Tissue

25.6 Glomus Tumor

References

Chapter 26: Selected Benign Tumors

26.1 Lipoma

26.2 Lipomatosis

26.3 Lipoblastoma/Lipoblastomatosis

26.4 Angiolipomas

26.5 Angiomyolipoma

26.6 Angiomyelolipoma

26.7 Hibernoma

26.8 Elastofibroma

26.9 Granular Cell Tumors

26.10 Hemangioma

26.11 Leiomyoma

26.12 Schwannoma

26.13 Neurofibroma

26.14 Myxoma

26.15 Angiomyxoma

26.16 Angiofibroma

References

Chapter 27: Reactive Lesions

27.1 Myositis Ossificans

27.2 Nodular Fasciitis

27.3 Sarcoma Masquerade

References

Index

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Tags: Murray Brennan, Cristina Antonescu, Kaled Alektiar, Robert Maki, Soft Tissue