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MRI Negative Epilepsy Evaluation and Surgical Management 1st editon by Elson So ISBN 1316189015 9781316189016

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ISBN 10: 1316189015
ISBN 13: 9781316189016
Author: Elson L. So

Drug-resistant epilepsy with negative MRI is frequently seen in patients considered for epilepsy surgery; however, clinical evaluation and surgical treatment is very complex and challenging. Advanced imaging techniques are needed to detect the location of the epileptogenic zone. In most cases, intracranial EEG recording is required to delineate the region of seizure onset – this carries some risks of major complications. Moreover, the borders between the recorded seizure onset and the location of important brain functions are often indistinct in MRI-negative epilepsy. Overall, the outcome of MRI-negative surgery is less favorable than that of MRI-positive surgery, but it can significantly improve with optimal management. Each chapter critically appraises the role and value of specific diagnostic and treatment techniques to address the challenges of MRI-negative epilepsy surgery. Authors critique evidence and share their expertise on the diagnostic options and surgical approaches that make epilepsy surgery possible and worthwhile in patients with this condition.

MRI Negative Epilepsy Evaluation and Surgical Management 1st Table of contents:

1. Scope and implications of MRI-negative refractory focal epilepsy

2. Seizure semiology and scalp EEG in MRI-negative refractory focal epilepsy

3. Clinical and advanced techniques for optimizing MRI in refractory focal epilepsy

4. PET in MRI-negative refractory focal epilepsy

5. Advanced SPECT image processing in MRI-negative refractory focal epilepsy

6. MEG and magnetic source imaging in MRI-negative refractory focal epilepsy

7. Electric source imaging in MRI-negative refractory focal epilepsy

8. Functional MRI in MRI-negative refractory focal epilepsy

9. Multimodality image coregistration for MRI-negative epilepsy surgery

10. Subdural electrode implantation and recording in MRI-negative epilepsy surgery

11. Depth electrode and stereoelectroencephalography in MRI-negative epilepsy

12. Ultraslow and high-frequency recordings in MRI-negative refractory focal epilepsy

13. Cortical mapping in MRI-negative epilepsy surgery

14. Localization and surgery for MRI-negative temporal lobe and temporal-plus epilepsies

15. Localization and surgery in MRI-negative frontal lobe epilepsies

16. Localization and surgery in MRI-negative posterior cortex epilepsies

17. MRI-negative refractory focal epilepsy in childhood

18. Surgical approaches and techniques in MRI-negative focal epilepsy

19. Histopathology findings in MRI-negative focal epilepsy

20. Neuropsychological issues in MRI-negative focal epilepsy surgery: evaluation and outcomes

21. Conclusion

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