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Optogenetics From Neuronal Function to Mapping and Disease Biology 1st Edition by Krishnarao Appasani 1107053013 9781107053014

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ISBN 10: 1107053013

ISBN 13: 9781107053014

Author: Krishnarao Appasani

Discovered little more than a decade ago, optogenetics – a revolutionary technique combining genetic and optical methods to observe and control the function of neurons – is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson’s disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

Optogenetics From Neuronal Function to Mapping and Disease Biology 1stTable of contents: 

Part I Optogenetics in Model Organisms

1 Introduction to Optogenetics: From Neuronal Function to Mapping and Disease Biology

2 Uncovering Key Neurons for Manipulation in Mammals

3 From Connectome to Function: Using Optogenetics to Shed Light on the Caenorhabditis elegans Nervou

4 From Synapse to Behavior: Optogenetic Tools for the Investigation of the Caenorhabditis elegans Ne

5 Using Optogenetics In Vivo to Stimulate Regeneration in Xenopus laevis

Part II Opsin Biology, Tools, and Technology Platform

6 Sodium and Engineered Potassium Light-Driven Pumps

7 Methods for Simultaneous Electrophysiology and Optogenetics In Vivo

8 Application of an Optogenetic Technique to a Study of Activity-dependent Axon Growth in the Develo

9 Development of an Optogenetic Tool to Regulate Protein Stability In Vivo

10 Photoactivatable Nucleotide Cyclases for Synthetic Photobiology Applications

11 Bioluminescence Activation of Light-sensing Molecules

Part III Optogenetics in Neurobiology, Brain Circuits, and Plasticity

12 Optogenetics for Neurological Disorders: What Is the Path to the Clinic?

13 Optogenetic Control of Astroglia

14 Optogenetics for Neurohormones and Neuropeptides: Focus on Oxytocin

15 Optogenetic Approaches to Investigating Brain Circuits

16 Optogenetic Mapping of Neuronal Connections and their Plasticity

Part IV Optogenetics in Learning, Neuropsychiatric Diseases, and Behavior

17 Optogenetics to Study Reward Learning and Addiction

18 Optogenetics and the Dissection of Neural Circuits Underlying Depression and Substance-use Disord

19 Optogenetics Research in Behavioral Neuroscience: Insights into the Brain Basis of Reward Learnin

20 Toward an Optogenetic Therapy for Epilepsy

21 Using Optogenetics and Stem Cell-derived Neural Engraftment Techniques to Restore Lost Motor Func

Plates

Part V Optogenetics in Vision Restoration and Memory

22 Optogenetics in Treating Retinal Disease

23 Optogenetics for Vision Recovery: From Traditional to Designer Optogenetic Tools

24 A Promise of Vision Restoration

25 Holographic Optical Neural Interfacing with Retinal Neurons

26 Strategies for Restoring Vision by Transducing a Channelrhodopsin Gene into Retinal Ganglion Cell

27 Optogenetic Dissection of a Top-down Prefrontal to Hippocampus Memory Circuit

Part VI Optogenetics in Sleep, Prosthetics, and Epigenetics of Neurodegenerative Diseases

28 Optogenetic Dissection of Sleep–Wake Control: Evidence for a Thalamic Control of Sleep Architec

29 Optogenetics and Auditory Implants

30 Optogenetic Stimulation for Cochlear Prosthetics

31 The Role of Amino Acids in Neurodegenerative and Addictive Diseases

32 Optogenetics in Deep Brain Stimulation: Ethical Considerations

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