Pediatric and Adolescent Oncofertility Best Practices and Emerging Technologies 1st edition by Teresa Woodruff, Yasmin Gosiengfiao ISBN 3319329734 9783319329734
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ISBN 10: 3319329734
ISBN 13: 9783319329734
Author: Teresa Woodruff, Yasmin Gosiengfiao
Reflecting the increasing interest in fertility management for pediatric and adolescent patients and fulfilling an urgent need to have a comprehensive guide to the management of these individuals, this is the first book of its kind to present a comprehensive discussion of pediatric and adolescent oncofertility. It carefully examines the impact of pediatric cancer and cancer therapy on fertility and presents both current and emerging fertility preservation techniques for both males and females, such as cryopreservation. Fertility concerns beyond cancer are also discussed, including disorders of sexual differentiation, gender dysphoria and thalassemia. Practical chapters on pediatric oncofertility in the clinic round out the book, covering setting up a practice, counseling and consent, disclosure and insurance considerations. Concluding chapters document fertility preservation techniques and outcomes internationally, with contributions from Portuguese, Brazilian and Japanese authors. Timely and wide-ranging, Pediatric and Adolescent Oncofertility is an ideal resource for reproductive medicine specialists, pediatric oncologists, and primary care physicians treating pediatric and adolescent cancer patients looking to protect fertility options.
Pediatric and Adolescent Oncofertility Best Practices and Emerging Technologies 1st Table of contents:
Chapter 1: Fertility Risk with Cancer Therapy
Introduction
Estimating Risk
Males
Females
Minimizing Risk
Gonadotropin-Releasing Hormone Agonist
Imatinib
Bone Marrow-Derived Mesenchymal Stem Cells
Sphingosine-1-phosphate (S1P)
Tamoxifen
AS101
Granulocyte Colony-Stimulating Factor (G-CSF)
Conclusion
References
Chapter 2: Fertility Preservation Options for Female Pediatric and Adolescent Oncology Patients
Introduction
Protection of Ovarian Function
Ovarian Transposition
Ovarian Suppression
Assisted Reproductive Endocrinology
Embryo and Oocyte Cryopreservation
Ovarian Tissue Cryopreservation and Transplantation
Assessment of Ovarian Reserve
Reproductive Options Post Therapy
Donor Oocytes and Embryos
Fertility Preservation Post Therapy
Gestational Carrier
Adoption
Access to Fertility Preservation
Ethical Considerations
Future Directions
Generation of Gametes from Somatic Cells
Coverage of Fertility Preservation by Insurance
Conclusion
References
Chapter 3: Assessing Ovarian Reserve
Background
Assessing Ovarian Reserve
Menstrual Cycles
Antral Follicle Counts and Ovarian Volume
Endocrine Hormones
Follicle-Stimulating Hormone (FSH), Inhibin B, and Estradiol
Anti-Mullerian Hormone (AMH)
Current Data on AMH in Children Receiving Cancer Therapy
Ovarian Reserve Testing as a Predictor of Menstrual Pattern and Fertility
Effect of Female Hormones on Ovarian Reserve Testing
References
Chapter 4: Contraception and Menstrual Suppression for Adolescent and Young Adult Oncology Patien
Contraception
Survivors
Menstrual Regulation and Suppression
GnRH Agonist
Progestin-Only Pills
Depot Medroxyprogesterone Acetate
Combined Hormonal Contraception (Pill, Patch, Ring)
Levonorgestrel IUD for Menstrual Suppression
Appendix: Medical Eligibility Criteria for Contraceptive Use
References
Chapter 5: Female Sexual Function in Childhood, Adolescent, and Young Adult Cancer Survivors
Scope of the Problem
Barriers to Care
Sexual Development
Infancy and Childhood
Preadolescence
Adolescence
Sexual Development in Survivors of Childhood Cancer
Risk Factors for Sexual Dysfunction
Long-Term and Late Effects of Cancer Treatment on Sexual Functioning
Physiologic Effects
Psychosocial Effects
Social Effects
Female Sexual Dysfunction
Female Sexual Interest/Arousal Disorder (FSIAD)
Female Orgasmic Disorder
Genito-pelvic Pain/Penetration Disorder (GPPPD)
Screening and Assessment
Treatment
Education and Setting of Expectations
Non-pharmacologic Therapies
Pharmacologic Therapies
When to Refer
Conclusion
References
Chapter 6: Vitrification of Ovarian Tissue for Fertility Preservation
Introduction
Vitrification: Facts and Fallacies
Development of Ovarian Tissue Vitrification Based on Cryobiological Principles
Endpoints of Vitrification Success
Nonhuman Primate Models of Ovarian Tissue Vitrification
Successful Vitrification of Human Ovarian Tissue
References
Chapter 7: Opportunities for Enabling Puberty
Introduction
Normal Initiation of Puberty
Effects of Sex Hormone on Other Organ Systems
Primary Hypogonadism from Natural Causes
Primary Hypogonadism from Gonadotoxic Reagents
Current Practices for Restoring Endocrine Function
Current Practices of Fertility Preservation and Restoration in Females
Experimental Practices for Fertility and Endocrine Restoration in Females
Current Practices of Fertility Preservation in Males
Experimental Procedures for Fertility Preservation and Endocrine Restoration in Males
Summary
References
Chapter 8: Male Fertility Preservation: Current Options and Advances in Research
Introduction
Sperm Banking: The Gold Standard Procedure for Male Fertility Preservation
Testicular Sperm Extraction (TESE)
TESE for Men and Adolescent Boys with Klinefelter Syndrome
Gonadal Shielding
Testicular Tissue Banking: An Experimental Procedure for Fertility Preservation
Considerations for Testicular Tissue Collection, Processing, and Freezing
Testicular Cell-Based Methods to Preserve and Restore Male Fertility
Spermatogonial Stem Cell Transplantation
Translating Spermatogonial Stem Cell Transplantation into the Clinic: Challenges and Opportuniti
Spermatogonial Stem Cell Culture
Malignant Contamination
De Novo Testicular Morphogenesis
Testicular Tissue-Based Methods to Preserve and Restore Male Fertility
Testicular Tissue Grafting and Xenografting
Testicular Tissue Organ Culture
Induced Pluripotent Stem Cell-Based Methods to Preserve and Restore Male Fertility
Conclusions
References
Chapter 9: Assessing Testicular Reserve in the Male Oncology Patient
Overview
Evaluation
Hormones
Semen Testing
Future Direction
References
Chapter 10: Male Sexuality
Normal Sexual Development and Function
Erectile Dysfunction (ED)
Etiology
Diagnosis
Sexual History
Medical History
Physical Examination
Laboratory Testing
Specialized Diagnostic Tests
Treatment Options
Ejaculatory Dysfunction
Premature Ejaculation
Etiology
Diagnosis
Treatment
Inhibited Ejaculation
Etiology
Treatment
Retrograde Ejaculation (RE)
Etiology
Diagnosis
Treatment
Painful Ejaculation
Psychosexual Problems
Sexuality in Survivors of Childhood Cancer
Risk for Sexual Dysfunction in Survivors of Childhood Cancer
Erectile Dysfunction
Etiology in Survivors
Incidence in Survivors
Ejaculatory Problems
Etiology in Survivors
Incidence in Survivors
Psychosexual Issues in Survivors
Cancer’s Impact on Normal Sexual Development
Relationships and Intimacy
How to Approach Cancer Survivors
Challenges and Future Directions
References
Chapter 11: Fertility Preservation in Patients with Disorders of Sex Development
References
Chapter 12: Fertility Preservation in Patients with Gender Dysphoria
Introduction
Nomenclature
Current Treatment Guidelines
Psychological Evaluation
Puberty Suppression
Cross-Sex Hormones
Testosterone Treatment for Trans-boys and Trans-men
Estrogen Treatment for Trans-girls and Trans-women
Cross-Sex Hormones Effect on Fertility
Estrogen and Fertility in Trans-women
Animal Data
Evidence in Humans
Environmental Estrogens
Elevated Estrogen in Obese Men
Summary
Testosterone and Fertility in Trans-men
Animal Data
Evidence in Humans
PCOS Data
Reports of Pregnancy in Trans-men
Summary
Ethics of Fertility Preservation Options for Trans-individuals
Fertility Preservation Options Prior to Initiation of Cross-Sex Hormones
Trans-women
Trans-men
Special Considerations
Fertility Preservation After Puberty Suppression
Fertility Preservation Options at Time of Gonadectomy
Future Research Priorities
References
Chapter 13: The Importance of Disclosure for Sexual Minorities in Oncofertility Cases
Overview
LGBTQ Populations and Cancer
Disclosure of Gender Identify and Sexual Orientation in Healthcare
Discussion of Fertility Considerations for LGBTQ AYA Cancer Patients
Availability of and Challenges to Accessing FP and Biological Parenting Options for LGBTQ AYA
Policy and Practice
Conclusion
References
Chapter 14: Fertility Issues in Transfusion-Dependent Thalassemia Patients: Pathophysiology, Assess
Introduction
Pathophysiology and Evaluation of Fertility in TDT
Iron Overload, Hypogonadism, and Infertility
Mechanism of Iron Toxicity in Thalassemia
Iron, Oxidative Stress, and the Reproductive System
Thalassemia Women
Thalassemia Men
Pituitary Siderosis and Fertility in Thalassemia
Fertility Issues in Thalassemia Women
Conception and Obstacles for Attaining Pregnancy
Ovarian Reserve and Fertility Preservation
Prepregnancy Planning in Transfusion-Dependent Thalassemia Women
Pregnancies: Management, Outcomes, and Complications
Fertility Issues in Thalassemia Men
Assessment of Reproductive Potential
Hormonal Assessment
Sperm Analysis
Paternity and Fertility Evaluation
Induction of Spermatogenesis and Fertility Preservation
References
Chapter 15: Setting Up a Pediatric Oncofertility Practice
Introduction
The Oncofertility Team
Primary Team Members
Oncofertility Consultation Process
Laboratory Management
Financial Concerns
Shared Decision-Making Tool
Documentation
Communication and Institutional Awareness
Cultural Considerations
Reference
Chapter 16: Optimal Technique for Laparoscopic Oophorectomy for Ovarian Tissue Cryopreservation in
Preoperative Considerations
Operative Technique
Summary
References
Chapter 17: The Fertility Preservation (FP) Consult
The Primary Treatment Team
Assessing Risk of Infertility
Counseling Children and Adolescents
Discussing Cost, Consent, and Disposal of Tissue in Event of Death
Fertility Preservation and Sexual Health Counseling After Treatment Is Completed
Conclusion
References
Chapter 18: Ethical Issues in Pediatric and Adolescent Fertility Preservation
Introduction
Assent/Consent
Best Interest Standard
Parental and Provider Pressure
Cost and Insurance Coverage
Experimental Treatment
Conclusion
References
Chapter 19: Optimizing the Decision-Making Process About Fertility Preservation in Young Female Ca
Introduction
Brief Notes on Female Fertility Preservation Methods
The Decision-Making Process About Female FP
Research with Female Cancer Patients
Research with Female Cancer Survivors
The Prospective Intervention Model of the Portuguese Centre for Fertility Preservation
Clinical Practice
Adaptation and Development of Information Resources for Shared Decision-Making About FP
Research Projects
Oncofertility Consortium® Global Partner
Discussion
Implications for Research and Clinical Practice
References
Chapter 20: Fertility Preservation in Japanese Children and Adolescents with Cancer
Chapter 21: Managing Fertility Preservation in Childhood Cancer Patients in Brazilian Scenario
Introduction
Fertility Preservation for Cancer Patients
Childhood Cancer and Fertility Preservation
Experience of Brazilian Oncofertility Consortium Centers Members
Conclusion
References
Index
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Tags: Teresa Woodruff, Yasmin Gosiengfiao, Adolescent Oncofertility, Emerging Technologies