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Pediatric Clinical Pharmacology 1st edition by Hannsjorg Seyberth ISBN 9783642201950 3642201954

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Product details:

ISBN 10: 3642201954
ISBN 13: 9783642201950 
Author:   Hannsjörg W. Seyberth

The objective of this volume is to give an overview of the present state of the art of pediatric clinical pharmacology including developmental physiology, pediatric-specific pathology, special tools and methods for development of drugs for children (assessment of efficacy, toxicity, long-term safety etc.) as well as regulatory and ethical knowledge and skills. In the future, structural and educational changes have to lead back to a closer cooperation and interaction of pediatrics with (clinical) pharmacology and pharmacy.
 

Table of contents:

Part I: General Considerations and Methodological Aspects

  1. Basics and Dynamics of Neonatal and Pediatric Pharmacology
  2. Developmental Pharmacokinetics
  3. Principles of Therapeutic Drug Monitoring
  4. Drug Delivery and Formulations

Part II: Development of Pediatric Medicines

  1. Development of Pediatric Medicines: Concepts and Principles
  2. Study Design and Simulation Approach
  3. Efficacy Assessment in Pediatric Studies
  4. Safety Assessment in Pediatric Studies
  5. Small Sample Approach and Statistical Aspects
  6. Sample Collection and Biobanking
  7. Ethical Considerations in Pediatric Research
  8. Pediatric Regulatory Initiatives

Part III: Specific Pediatric Pharmacology

  1. Fetal Medicine and Treatment
  2. Fetal Risks of Maternal Pharmacotherapy
  3. Antiepileptic Treatment in Pregnant Women
  4. Preventive Medicines
  5. Postmarketing Surveillance
  6. Global Aspects of Drug Development

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