Platelets and Megakaryocytes Volume 2 Perspectives and Techniques 1st edition by Jonathan Gibbins, Martyn Mahaut Smith ISBN 1592597833 978-1592597833

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ISBN 10: 1592597833
ISBN 13: 978-1592597833
Author: Jonathan Gibbins, Martyn Mahaut Smith

12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 

Platelets and Megakaryocytes Volume 2 Perspectives and Techniques 1st Table of contents:

Signaling Receptors on Platelets and Megakaryocytes
Donna Woulfe, Jing Yang, Nicola Prevost, Peter, Ryan Fortna, Maximilian Tognolinital Pages 3-11
Manipulation of Gene Expression in Megakaryocytes
Nikla R. Cambokas, George). Murphy, Johan Tampton
Pages 33-55
In Vitro Changes of Platelet Parameters
Jon Rivera, Maria L. Loran, Vicente Vicente
Pages 57-72
Pharmacological Approaches to Studying Platelet Function
Sunna M.C.Han
Pages 73-85
Inhibitors of Cellular Signalling Targets
Chris J. Vlahos, Louis F.Stancat
Pages 67-102
Signaling Techniques
Front Matter
Pages 103-103
Ligand-Binding Assays for Collagen
Stephanie M.Jung, Mad Mor
Pages 105-114
Download chapter PDF
Use of Radiolabeled 2-Methylthio-ADP to Study P2Y Receptors on Platelets and Cell Lines
Pierre Savi Jean-Marcbert
Pages 115-124
Ligand-Binding Assays
Derma Cos
Pages 125-137
Techniques for Analysis of Proteins by SDS-Polyacrylamide Gel Electrophoresis and Western Blotting
Jonathan M. Gibbins Pages 139-151
Study of Tyrosine Kinases and Protein Tyrosine Phosphorylation
Jonathan M. Gibbins
Pages 153-167
Protein Tyrosine Phosphatases
Matthew L.Jones, Alastair W. Pale
Pages 160-177
The Study of Serine-Threonine Kinases
Gertie Carter, We
Pages 179-199

Signaling Techniques
Evaluation of Nitrotyrosine-Containing Proteins in Blood Platelets
Khalid M. Nasen, Rocio Riba,Max Tre
Pages 301-312
Nitric Oxide Signaling in Platelets
Sylvia Y. Low, K. Richard Bruder
Pages 313-333
Snake Venom Toxins Affecting Platelet Function
Robert K. Andrews, Elizabeth C. Gardiner, Michael C. Berndt
Pages 335-347
Peptide Synthesis in the Study of Collagen-Platelet Interactions
C. Graham Knight, Catherine M.Only, Richard W. Farme
Pages 349-363
Platelet Permeabilization
Robert Flaumenta
Pages 365-378
Molecular and Post-Genomic Techniques
Front Matter
Pages 379-379
Downloa
Using Retroviruses to Express Genes in Primary Megakaryocyte Lineage Ce
Meenakshi Caur, George).Murphy, John Frampton, Andrew D. Leavitt
Pages 381-396
Use of Antisense Oligonucleotide Technology to Investigate Signaling Pati Megakaryocytes
Hava Avraham, Shalom Avraham, Radoslaw Za
Pages
397-406
GFP Fusion Proteins to Study Signaling in Live Cells
Simon A. Walker, Gyles. Cooler, Peter J.Cullen Pages 407-419
Two-Dimensional Polyacrylamide Gel Electrophoresis for Platelet Proteor
Katrin Marcus, Helmut.Meyer
Pages 421-433
Preparation of mRNA and cDNA Libraries From Platelets and Megakaryocy
Benjamin Z. S. Paul, Jiango Jin, Satya P. Kunapul
Pages 435-453
Platelet Receptor Structures and Polymorphisms
Thomas Kunicki, Steven lead,Daniel R.Salmon
Pages 455-476
Gene Array Technology and the Study of Platelets and Megakaryocytes
Lloyd T. Lam, Emeryk
Pages 479-490

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