Principles and Practice of Skin Toxicology

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Product details:

• ISBN 10: 0470511729
  
• ISBN 13: 978-0470511725
  
• Author: Robert Chilcott, Shirley Price

Taking a “bottom up” approach to studying skin toxicology, this basic introduction to the principles and practice of dermal toxicology explores skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity, and in vitro alternatives. Coverage of global legislation and regulatory aspects, a user-friendly layout with learning boxes, and summaries of each chapter round out the coverage and will appeal to practitioners of toxicology, clinical researchers, researchers in industry and academia as well as MSc and PhD students of toxicology.

Table contents:

PART I: Introduction

1. Cutaneous anatomy and function

2. Biochemistry of the skin

3. Skin photobiology

PART II: Skin Absorption

4. Skin as a route of entry

5. Physicochemical Factors Affecting Skin Absorption

6. Principles of Diffusion and Thermodynamics

7. In vivo measurements of skin absorption

8. In vitro percutaneous absorption measurements

PART III: Toxicological Assessment

9. Skin immunology and sensitisation

10. In vitro phototoxicity assays

11. In vitro alternatives for irritation and corrosion assessment

12. Instruments for measuring skin toxicity

PART IV: Clinical Aspects

13. Introduction to dermatology

14. Clinical aspects of phototoxicity

15. Occupational skin diseases

16. Prevention of occupational skin disease

PART V: Regulatory

17. Occupational skin exposures: legal aspects

18. Safety assessment of cosmetics: an EU perspective

20. Glossary of main terms and abbreviations

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