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Principles of Molecular Diagnostics and Personalized Cancer Medicine 1st edition by Dongfeng Tan ISBN 9781451131970 1451131976

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Product details:

ISBN 10: 1451131976
ISBN 13: 9781451131970
Author:  Dongfeng Tan 

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
 

Table of contents:

Section I: Introduction of Cancer Biology and Cancer GeneticsExpandable section

Chapter 1: Cell Proliferation and Apoptosis
Chapter 2: Cancer Stem Cells
Chapter 3: Cell Signal Transduction
Chapter 4: Oncogenes
Chapter 5: Tumor Suppressor Genes
Chapter 6: Viruses and Human Cancers: Pathogenesis and Therapeutic Implication

Section II: Molecular TechniquesExpandable section

Chapter 7: Introduction to Molecular Techniques and Instrumentation
Chapter 8: Transcriptome Analysis
Chapter 9: Immunohistochemistry
Chapter 10: Cancer Genomic Sequencing
Chapter 11: Mass Spectrometry: Principles and Applications in Cancer Diagnosis and Management
Chapter 12: Cancer Proteomics
Chapter 13: Morphoproteomics
Chapter 14: Flow Cytometry
Chapter 15: Cancer Cytogenomics
Chapter 16: DNA Hypermethylation in Cancer
Chapter 17: Single Nucleotide Polymorphisms

Section III: Molecular Tests and Cancer ManagementExpandable section

Chapter 18: Overview of Molecular Tests and Cancer Management
Chapter 19: Molecular Screening, Genetic Counseling, and Cancer Prevention: Lynch Syndrome as a Model
Chapter 20: Molecular Imaging and Cancer Management: PET and MR Agents for Molecular Imaging of Cancer Metabolism
Chapter 21: Detection and Molecular Monitoring of Minimal Residual Diseases in Myeloid Neoplasms
Chapter 22: Molecular Assessment of Cancer Prognosis
Chapter 23: Quality Control, Assurance, and Standardization of Molecular Diagnostics
Chapter 24: Biostatistics and Bioinformatics
Chapter 25: In Vitro Companion Diagnostic and Anti-cancer Drug Co-development: Regulatory Perspectives

Section IV: Molecular Diagnostics of Common MalignanciesExpandable section

Chapter 26: Molecular Biology and Pathology of Lung Cancer: Genotype–Morphology Correlation
Chapter 27: Molecular Diagnosticsof Breast Cancer
Chapter 28: Molecular Diagnostics of Colorectal Cancer
Chapter 29: Molecular Diagnostics of Esophageal and Gastric Cancers
Chapter 30: Molecular Biology of Prostate Cancer: Practical Considerations for Diagnosis and Prognosis
Chapter 31: Molecular Diagnostics of Hepatocellular Carcinoma
Chapter 32: Molecular Diagnostics of Pancreatic Cancer
Chapter 33: Molecular Diagnostics of Head and Neck Cancer
Chapter 34: Immunohistochemical and Molecular Diagnosis of Melanoma
Chapter 35: Molecular Diagnostics of Hematopoietic Neoplasms
Chapter 36: Molecular Diagnostics of Lymphomas
Chapter 37: Molecular Diagnostics of Gynecologic Neoplasms
Chapter 38: Molecular Diagnostics of Bladder and Kidney Cancers
Chapter 39: Molecular Diagnosis of Soft Tissue Sarcomas
Chapter 40: Molecular Diagnosis of Glioma
Chapter 41: Molecular Diagnostics of Pediatric Neoplasms
Chapter 42: Molecular Diagnostics of Metastatic Malignancies

Section V: Molecular Basis of Cancer TherapeuticsExpandable section

Chapter 43: DNA Repair and Cancer Therapeutics
Chapter 44: Monoclonal Antibodies for the Treatment of Cancer
Chapter 45: Vaccines and Cancer Therapy
Chapter 46: Cancer Gene Therapy: Nucleic Acids as Therapeutic Agents
Chapter 47: Anti-angiogenesis Therapy of Cancer
Chapter 48: MicroRNAs and Cancer Therapeutics
Chapter 49: Molecular Basis of Cancer Radiation Treatment
Chapter 50: Nanotechnology and Cancer Therapy
Chapter 51: New Approaches to Integration of Personalized Medicine in Early Cancer Drug Development

Section VI: Personalized Medicine and Targeted Therapy of CancerExpandable section

Chapter 52: Personalized Medicine and Targeted Therapy of Lung Cancer
Chapter 53: Personalized Medicine and Targeted Therapy of Breast Cancer
Chapter 54: Personalized Medicine and Targeted Therapy for Colorectal Cancer
Chapter 55: Personalized Medicine and Targeted Therapy of Esophageal Cancer
Chapter 56: Personalized Medicine and Targeted Therapy of Gastric Cancer
Chapter 57: Personalized Medicine and Targeted Therapy for Prostate Cancer
Chapter 58: Personalized Medicine and Targeted Therapy of Hepatocellular Carcinoma
Chapter 59: Personalized Medicine and Targeted Therapy of Pancreatic Cancer: Current Status and Proposed Strategies
Chapter 60: Personalized Medicine and Targeted Therapy of Neuroendocrine Neoplasms
Chapter 61: Personalized Medicine and Targeted Therapy of Head and Neck Cancer
Chapter 62: Personalized Medicine and Targeted Therapy for Melanoma
Chapter 63: Personalized Medicine and Targeted Therapy of Leukemia
Chapter 64: Personalized Medicine and Targeted Therapy of Gynecologic Cancers
Chapter 65: Personalized Medicine and Targeted Therapy of Renal Cell Carcinoma
Chapter 66: Personalized Medicine and Targeted Therapy of Gliomas
Chapter 67: Personalized Medicine and Targeted Therapy for Osteosarcoma
Chapter 68: Molecular Basis of Chemoradiotherapy and High-Precision Radiotherapy

Section VII: Future of Molecular Diagnostics and Personalized Cancer MedicineExpandable section

Chapter 69: New Approaches to Personalized Medicine and Targeted Drug Discovery
Chapter 70: The Future of Molecular Diagnostics in Oncology

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