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Prostate Cancer Signaling Networks Genetics and New Treatment Strategies 1st Edition by Richard Pestell, Marja Nevalainen ISBN 0367331409 9780367331400

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Product details:
ISBN 10: 0367331409
ISBN 13: 9780367331400
Author: Richard Pestell, Marja Nevalainen

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies”, the authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies” provides a comprehensive translational resource as well as an important source of information for prostate cancer patients.

Prostate Cancer Signaling Networks Genetics and New Treatment Strategies 1st Edition Table of contents:

  1. Introduction to Prostate Cancer

    • Epidemiology and Risk Factors
    • Biology and Pathogenesis of Prostate Cancer
    • Overview of Current Therapies

  2. Molecular Signaling Pathways in Prostate Cancer

    • Androgen Receptor Signaling
    • PI3K/Akt/mTOR Pathway
    • Ras/Raf/MEK/ERK Pathway
    • Wnt/β-catenin Signaling

  3. Genetic and Epigenetic Changes in Prostate Cancer

    • Genetic Mutations and Chromosomal Aberrations
    • Role of Oncogenes and Tumor Suppressors
    • Epigenetic Alterations in Prostate Cancer

  4. Prostate Cancer Stem Cells

    • Stem Cell Hypothesis in Prostate Cancer
    • Molecular Markers of Prostate Cancer Stem Cells
    • Targeting Stem Cells for Treatment

  5. Tumor Microenvironment and Angiogenesis

    • Role of the Microenvironment in Cancer Progression
    • Prostate Cancer and Tumor Vasculature
    • Immune Cell Interactions in the Tumor Niche

  6. Metastasis in Prostate Cancer

    • Mechanisms of Prostate Cancer Metastasis
    • Molecular Drivers of Metastatic Spread
    • Diagnostic and Therapeutic Strategies for Metastasis

  7. Targeted Therapies and Novel Treatment Strategies

    • Targeting Androgen Receptor Signaling
    • Inhibition of PI3K/Akt/mTOR Pathway
    • Immunotherapy in Prostate Cancer
    • Gene Therapy and RNA-Based Therapies

  8. Advances in Biomarker Discovery for Prostate Cancer

    • Prognostic and Predictive Biomarkers
    • Liquid Biopsy and Non-invasive Diagnostics
    • Biomarkers for Therapeutic Response

  9. Clinical Trials and Emerging Therapies

    • Overview of Key Clinical Trials
    • New Drug Approvals and Treatment Combinations
    • Personalized Medicine in Prostate Cancer

  10. Future Directions and Challenges

  • Overcoming Resistance to Current Therapies
  • Advances in Immuno-oncology
  • Translating Basic Research into Clinical Practice

Appendix

  • Key Resources and Research Databases
  • Glossary of Terms
  • Index

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