Proteins Structure and Function 1st edition by David Whitford – Ebook PDF Instant Download/Delivery: 0471498947 , 978-0471498940
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ISBN 10: 0471498947
ISBN 13: 978-0471498940
Author: David Whitford
Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability.
The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins.
An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
Proteins Structure and Function 1st Table of contents:
1: An Introduction to Protein Structure and Function
A Brief and Very Selective Historical Perspective
The Biological Diversity of Proteins
Proteins and the Sequencing of the Human and Other Genomes
Why Study Proteins?
2: Amino Acids: the Building Blocks of Proteins
The 20 Amino Acids Found in Proteins
The Acid–Base Properties of Amino Acids
Stereochemical Representations of Amino Acids
Peptide Bonds
The Chemical and Physical Properties of Amino Acids
Detection, Identification and Quantification of Amino Acids and Proteins
Stereoisomerism
Non-Standard Amino Acids
Summary
Problems
3: The Three-Dimensional Structure of Proteins
Primary Structure or Sequence
Secondary Structure
Tertiary Structure
Quaternary Structure
The Globin Family and the Role of Quaternary Structure in Modulating Activity
Immunoglobulins
Cyclic Proteins
Summary
Problems
4: The Structure and Function of Fibrous Proteins
The Amino Acid Composition and Organization of Fibrous Proteins
Keratins
Fibroin
Collagen
Summary
Problems
5: The Structure and Function of Membrane Proteins
The Molecular Organization of Membranes
Membrane Protein Topology and Function Seen Through Organization of the Erythrocyte Membrane
Bacteriorhodopsin and the Discovery of Seven Transmembrane Helices
The Structure of the Bacterial Reaction Centre
Oxygenic Photosynthesis
Photosystem I
Membrane Proteins Based on Transmembrane β Barrels
Respiratory Complexes
Complex III, the Ubiquinol-Cytochrome C Oxidoreductase
Complex IV or Cytochrome Oxidase
The Structure of ATP Synthetase
ATPase Family
Summary
Problems
6: The Diversity of Proteins
Prebiotic Synthesis and the Origins of Proteins
Evolutionary Divergence of Organisms and Its Relationship to Protein Structure and Function
Protein Sequence Analysis
Protein Databases
Gene Fusion and Duplication
Secondary Structure Prediction
Genomics and Proteomics
Summary
Problems
7: Enzyme Kinetics, Structure, Function, and Catalysis
Enzyme Nomenclature
Enzyme Co-Factors
Chemical Kinetics
The Transition State and the Action of Enzymes
The Kinetics of Enzyme Action
Catalytic Mechanisms
Enzyme Structure
Lysozyme
The Serine Proteases
Triose Phosphate Isomerase
Tyrosyl tRNA Synthetase
EcoRI Restriction Endonuclease
Enzyme Inhibition and Regulation
Irreversible Inhibition of Enzyme Activity
Allosteric Regulation
Covalent Modification
Isoenzymes or Isozymes
Summary
Problems
8: Protein Synthesis, Processing and Turnover
Cell Cycle
The Structure of Cdk and Its Role in the Cell Cycle
Cdk–Cyclin Complex Regulation
DNA Replication
Transcription
Eukaryotic Transcription Factors: Variation on a ‘Basic’ Theme
The Spliceosome and Its Role in Transcription
Translation
Transfer RNA (tRNA)
The Composition of Prokaryotic and Eukaryotic Ribosomes
A Structural Basis for Protein Synthesis
An Outline of Protein Synthesis
Antibiotics Provide Insight Into Protein Synthesis
Affinity Labelling and RNA ‘Footprinting’
Structural Studies of the Ribosome
Post-Translational Modification of Proteins
Protein Sorting or Targeting
The Nuclear Pore Assembly
Protein Turnover
Apoptosis
Summary
Problems
9: Protein Expression, Purification and Characterization
The Isolation and Characterization of Proteins
Recombinant DNA Technology and Protein Expression
Purification of Proteins
Centrifugation
Solubility and ‘Salting Out’ and ‘Salting in’
Chromatography
Dialysis and Ultrafiltration
Polyacrylamide Gel Electrophoresis
Mass Spectrometry
How to Purify a Protein?
Summary
Problems
10: Physical Methods of Determining the Three-Dimensional Structure of Proteins
Introduction
The Use of Electromagnetic Radiation
X-ray Crystallography
Nuclear Magnetic Resonance Spectroscopy
Cryoelectron Microscopy
Neutron Diffraction
Optical Spectroscopic Techniques
Vibrational Spectroscopy
Raman Spectroscopy
ESR and ENDOR
Summary
Problems
11: Protein Folding in Vivo and in Vitro
Introduction
Factors Determining the Protein Fold
Factors Governing Protein Stability
Folding Problem and Levinthal’s Paradox
Models of Protein Folding
Amide Exchange and Measurement of Protein Folding
Kinetic Barriers to Refolding
In Vivo Protein Folding
Membrane Protein Folding
Protein Misfolding and the Disease State
Summary
Problems
12: Protein Structure and a Molecular Approach to Medicine
Introduction
Sickle Cell Anaemia
Viruses and Their Impact on Health As Seen Through Structure and Function
HIV and AIDS
The Influenza Virus
p53 and Its Role in Cancer
Emphysema and α1-Antitrypsin
Summary
Problems
Epilogue
Glossary
Appendices
Bibliography
References
Index
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