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Pulmonary Circulation Diseases and Their Treatment 4th edition by Andrew Peacock ISBN 1498720005 9781498720007

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ISBN 10: 1498720005
ISBN 13: 9781498720007
Author: Andrew Peacock

 Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment. This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society. Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.

Pulmonary Circulation Diseases and Their Treatment 4th Table of contents:

Introduction

  • Overview of Pulmonary Circulation and Right Heart Function

  • Importance of Understanding Pulmonary Vascular Disorders

  • Advances and Challenges in Pulmonary Hypertension

Part I: Physiology of Pulmonary Circulation

Chapter 1: Evolution and Anatomy of Pulmonary Circulation

  • Evolutionary Perspective

  • Pulmonary Vascular Architecture

  • Capillary Structure and Fragility

Chapter 2: Pulmonary Vascular Function

  • Pulmonary Blood Flow and Distribution

  • Pulmonary Vascular Resistance (PVR)

  • Pulmonary Capillary Pressure and Gas Exchange

  • Effects of Exercise on Pulmonary Hemodynamics

Part II: Right Heart Function in Pulmonary Circulation

Chapter 3: The Role of the Right Ventricle

  • Right Ventricular Anatomy and Function

  • Right Heart Adaptation to Increased Afterload

  • Right Ventricular Failure: Causes and Consequences

Part III: Pathophysiology of Pulmonary Vascular Disease

Chapter 4: Pathobiology of Pulmonary Arterial Hypertension (PAH)

  • Endothelial Dysfunction and Vasoconstriction

  • Pulmonary Arterial Remodeling

    • Smooth Muscle Hypertrophy

    • Inflammation and Immune Responses

  • Genetic and Molecular Mechanisms in PAH

Chapter 5: Subtypes and Risk Factors

  • Classification of Pulmonary Hypertension (PH)

  • Idiopathic and Heritable PAH

  • Systemic Sclerosis-Associated PAH (SSc-PAH)

  • Drug-Induced and Anorexigen-Related PAH

  • Connective Tissue Disease and PAH

Part IV: Clinical Assessment and Diagnosis

Chapter 6: Diagnostic Modalities

  • Echocardiography

  • Pulmonary Function Testing

  • Imaging Techniques (CT, MRI, V/Q Scans)

  • Right Heart Catheterization

    • Hemodynamic Parameters

    • Interpretation and Clinical Utility

Chapter 7: Biomarkers and Clinical Evaluation

  • Biomarkers in Pulmonary Vascular Disease

  • Functional Classification and Prognostic Indicators

  • Exercise Testing and 6-Minute Walk Distance

Part V: Therapeutic Strategies and Outcomes

Chapter 8: Pharmacologic Management of PAH

  • Endothelin Receptor Antagonists

  • Phosphodiesterase Type-5 Inhibitors

  • Prostacyclin Analogs and Receptor Agonists

  • Emerging Therapies and Combination Strategies

Chapter 9: Survival and Prognosis in PAH

  • Survival Trends Post-2002

  • Comparative Outcomes by PAH Subtype

    • SSc-PAH vs. Idiopathic/Heritable PAH

    • Impact of Early Diagnosis and Treatment

  • Implications for Personalized Medicine

Conclusion

  • Integrating Pathophysiology with Clinical Practice

  • Gaps in Treatment Response and Future Directions

  • The Need for Subtype-Specific Therapeutic Approaches

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Tags: Andrew Peacock, Pulmonary Circulation, Their Treatment