Rang & Dale’s Pharmacology 9th Edition by James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang – Ebook PDF Instant Download/Delivery: 0702074489, 978-0702074486
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Product details:
ISBN 10: 0702074489
ISBN 13: 978-0702074486
Author: James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang
Comprehensive yet easy to use, Rang and Dale’s Pharmacology has been providing core basic and clinical science information to students and healthcare practitioners worldwide for more than 25 years. The fully revised 9th Edition keeps you up to date with all that’s new in the field, including new and emerging drugs and recent studies. From cover to cover, you’ll progressively increase your knowledge of all relevant aspects of pharmacology, from a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs.
- Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more.
- Includes access to unique features online, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment.
- Features a color-coded layout for faster navigation and cross-referencing.
- Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Rang & Dale’s Pharmacology 9th Table of contents:
Section 1 General principles
1 What is pharmacology?
What Is a Drug?
Origins and Antecedents
Pharmacology in the 20Th and 21St Centuries
References and Further Reading
2 How drugs act
Introduction
Protein Targets for Drug Binding
Desensitisation and Tolerance
Quantitative Aspects of Drug–Receptor Interactions
The Nature of Drug Effects
References and Further Reading
3 How drugs act
Protein Targets for Drug Action
Receptor Proteins
Ion Channels as Drug Targets
Control of Receptor Expression
Receptors and Disease
References and Further Reading
4 How drugs act
Regulation of Intracellular Calcium
Excitation
Muscle Contraction
Release of Chemical Mediators
Epithelial Ion Transport
References and Further Reading
5 How drugs act
Introduction
Protein and Oligonucleotide Biopharmaceuticals
Oligonucleotides
Gene Therapy
Safety and Societal Issues
Therapeutic Applications
Concluding Remarks
References and Further Reading
6 Cell proliferation, apoptosis, repair and regeneration
Cell Proliferation
Angiogenesis
Apoptosis and Cell Removal
Pathophysiological Implications
Therapeutic Prospects
References and Further Reading
7 Cellular mechanisms
Introduction
The Innate Immune Response
The Adaptive Immune Response
Systemic Responses in Inflammation
References and Further Reading
8 Method and measurement in pharmacology
Bioassay
Animal Models of Disease
Pharmacological Studies in Humans
Clinical Trials
References and Further Reading
9 Absorption and distribution of drugs
Introduction
Physical Processes Underlying Drug Disposition
Drug Absorption and Routes of Administration
Distribution of Drugs in the Body
Special Drug Delivery Systems
References and Further Reading
10 Drug metabolism and elimination
Introduction
Drug and Metabolite Excretion
References and Further Reading
11 Pharmacokinetics
Introduction: Definition and Uses of Pharmacokinetics
Drug Elimination Expressed as Clearance
Single-Compartment Model
More Complicated Kinetic Models
Population Pharmacokinetics
Limitations of Pharmacokinetics
References and Further Reading
12 Individual variation, pharmacogenomics and personalised medicine
Introduction
Epidemiological Factors and Inter-Individual Variation of Drug Response
Genetic Variation in Drug Responsiveness
Therapeutic Drugs and Clinically Available Pharmacogenomic Tests
Conclusions
References and Further Reading
Section 2 Chemical mediators
13 Chemical mediators and the autonomic nervous system
Historical Aspects
The Autonomic Nervous System
Some General Principles of Chemical Transmission
Basic Steps in Neurochemical Transmission: Sites of Drug Action
References and Further Reading
14 Cholinergic transmission
Muscarinic and Nicotinic Actions of Acetylcholine
Acetylcholine Receptors
Nicotinic Receptors
Physiology of Cholinergic Transmission
Effects of Drugs on Cholinergic Transmission
References and Further Reading
15 Noradrenergic transmission
Catecholamines
Classification of Adrenoceptors
Physiology of Noradrenergic Transmission
Drugs Acting on Noradrenergic Transmission
References and Further Reading
16 5-Hydroxytryptamine and the pharmacology of migraine
5-Hydroxytryptamine
Migraine and Other Clinical Conditions in Which 5-HT Plays a Role
References and Further Reading
17 Purines
Introduction
Purinergic Receptors
Adenosine as a Mediator
ADP as a Mediator
ATP as a Mediator
Future Prospects
References and Further Reading
18 Local hormones 1
Introduction
What Is a ‘Mediator’?
Histamine
Eicosanoids
Leukotrienes
Other Important Fatty Acid Derivatives
Platelet-Activating Factor
Concluding Remarks
References and Further Reading
19 Local hormones 2
Introduction
General Principles of Protein and Peptide Pharmacology
Biosynthesis and Regulation of Peptides
Bradykinin
Neuropeptides
Cytokines
Proteins and Peptides That Down-Regulate Inflammation
Concluding Remarks
References and Further Reading
20 Cannabinoids
Plant-Derived Cannabinoids and Their Pharmacological Effects
Cannabinoid Receptors
Endocannabinoids
Synthetic Cannabinoids
Clinical Applications
References and Further Reading
21 Nitric oxide and related mediators
Introduction
Biosynthesis of Nitric Oxide and Its Control
Degradation and Carriage of Nitric Oxide
Effects of Nitric Oxide
Therapeutic Aspects
Clinical Conditions in Which Nitric Oxide May Play A Part
Related Mediators
References and Further Reading
Section 3 Drugs affecting major organ systems
22 The heart
Introduction
Physiology of Cardiac Function
Autonomic Control of the Heart
Cardiac Natriuretic Peptides
Ischaemic Heart Disease
Drugs That Affect Cardiac Function
References and Further Reading
23 The vascular system
Introduction
Vascular Structure and Function
Control of Vascular Smooth Muscle Tone
Vasoactive Drugs
Clinical Uses of Vasoactive Drugs
References and Further Reading
24 Atherosclerosis and lipoprotein metabolism
Introduction
Atherogenesis
Lipoprotein Transport
Prevention of Atheromatous Disease
Lipid-Lowering Drugs
References and Further Reading
25 Haemostasis and thrombosis
Introduction
Blood Coagulation
Drugs That Act on the Coagulation Cascade
Platelet Adhesion and Activation
Fibrinolysis (Thrombolysis)
References and Further Reading
26 Haematopoietic system and treatment of anaemia
Introduction
The Haematopoietic System
Types of Anaemia
Haematinic Agents
Haematopoietic Growth Factors
Haemolytic Anaemia
References and Further Reading
27 Anti-inflammatory and immunosuppressant drugs
Introduction
Cyclo-Oxygenase Inhibitors
Antirheumatoid Drugs
Anticytokine Drugs and Other Biopharmaceuticals
Drugs Used in Gout
Antagonists of Histamine
Possible Future Developments IN ANTIINFLAMMATORY THERAPY
References and Further Reading
28 Skin
Introduction
Structure of Skin
Common Diseases of the Skin
Drugs Acting on Skin
Principal Drugs Used in Skin Disorders
Agents Acting by Other Mechanisms
Concluding Remarks
References and Further Reading
29 Respiratory system
The Physiology of Respiration
Pulmonary Disease and Its Treatment
References and Further Reading
30 The kidney and urinary system
Introduction
Outline of Renal Function
The Structure and Function of the Nephron
Drugs Acting on the Kidney
Drugs That Alter the pH of the Urine
Drugs That Alter the Excretion of Organic Molecules
Drugs Used in Renal Failure
Drugs Used in Urinary Tract Disorders
References and Further Reading
31 The gastrointestinal tract
The Innervation and Hormones of the Gastrointestinal Tract
Gastric Secretion
Vomiting
The Motility of the GI Tract
Drugs for Chronic Bowel Disease
Drugs Affecting the Biliary System
Future Directions
References and Further Reading
32 The control of blood glucose and drug treatment of diabetes mellitus
Introduction
Control of Blood Glucose
Pancreatic Islet Hormones
Diabetes Mellitus
References and Further Reading
33 Obesity
Introduction
Obesity as a Health Problem
Homeostatic Mechanisms Controlling Energy Balance
The Pathophysiology of Human Obesity
Pharmacological Approaches to the Problem of Obesity
New Approaches to Obesity Therapy
References and Further Reading
34 The pituitary and the adrenal cortex
The Pituitary Gland
The Adrenal Cortex
New Directions in Glucocorticoid Therapy
References and Further Reading
35 The thyroid
Synthesis, Storage and Secretion of Thyroid Hormones
Regulation of Thyroid Function
Actions of the Thyroid Hormones
Transport and Metabolism of Thyroid Hormones
Abnormalities of Thyroid Function
Drugs Used in Diseases of the Thyroid
References and Further Reading
36 The reproductive system
Introduction
Endocrine Control of Reproduction
Drugs Affecting Reproductive Function
Drugs Used for Contraception
The Uterus
Erectile Dysfunction
References and Further Reading
37 Bone metabolism
Introduction
Bone Structure and Composition
Bone Remodelling
Disorders of Bone
Drugs Used in Bone Disorders
Potential New Therapies
References and Further Reading
Section 4 Nervous system
38 Chemical transmission and drug action in the central nervous system
Introduction
Chemical Signalling in the Nervous System
Targets for Drug Action
Drug Action in the Central Nervous System
The Classification of Psychotropic Drugs
References and Further Reading
39 Amino acid transmitters
Excitatory Amino Acids
Glutamate
γ-Aminobutyric Acid (GABA)
Glycine
Concluding Remarks
References and further reading
40 Other transmitters and modulators
Introduction
Noradrenaline
Dopamine
5-Hydroxytryptamine
Acetylcholine
Purines
Histamine
Other CNS Mediators
A Final Message
References and Further Reading
41 Neurodegenerative diseases
Protein Misfolding and Aggregation in Chronic Neurodegenerative Diseases
Mechanisms of Neuronal Death
Ischaemic Brain Damage
Alzheimer’s Disease
Parkinson’s Disease
Huntington’s Disease
Amyotrophic Lateral Sclerosis
Spinal Muscular Atrophy
Multiple Sclerosis
References and Further Reading
42 General anaesthetic agents
Introduction
Mechanism of Action of Anaesthetic Drugs
Intravenous Anaesthetic Agents
Inhalation Anaesthetics
Individual Inhalation Anaesthetics
Balanced Anaesthesia
References and Further Reading
43 Analgesic drugs
Neural Mechanisms of Pain
Analgesic Drugs
References and further reading
44 Local anaesthetics and other drugs affecting sodium channels
Local Anaesthetics
Other Drugs That Affect Sodium Channels
References and Further Reading
45 Anxiolytic and hypnotic drugs
The Nature of Anxiety and Its Treatment
Measurement of Anxiolytic Activity
Drugs Used to Treat Anxiety
Delayed Anxiolytic Effect of SSRIs and Buspirone
Drugs Used to Treat Insomnia (Hypnotic Drugs)
References and Further Reading
46 Antiepileptic drugs
Introduction
The Nature of Epilepsy
Antiepileptic Drugs
Muscle Spasm and Muscle Relaxants
References and Further Reading
47 Antipsychotic drugs
Introduction
The Nature of Schizophrenia
Antipsychotic Drugs
Future Developments
References and Further Reading
48 Antidepressant drugs
The Nature of Depression
Theories of Depression
Antidepressant Drugs
Clinical Effectiveness of Antidepressant Treatments
Future Antidepressant Drugs
Brain Stimulation Therapies
Drug Treatment of Bipolar Disorder
References and Further Reading
49 Psychoactive drugs
Introduction
Psychomotor Stimulants
Cognition-Enhancing Drugs
Psychedelic Drugs
Ketamine and Related Drugs
Depressants
Tolerance and Dependence
Synthetic Cannabinoids
References and Further Reading
50 Drug abuse and dependence
Drug Use and Abuse
References and Further Reading
Section 5 Drugs used for the treatment of infections and cancer
51 Basic principles of antimicrobial chemotherapy
Background
The Molecular Basis of Chemotherapy
Resistance to Antibacterial Drugs
Current Status of Antibiotic Resistance in Bacteria
References and Further Reading
52 Antibacterial drugs
Introduction
Antibacterial Agents That Interfere With Folate Synthesis or Action
β-Lactam Antibiotics and Other Agents That Interfere With Bacterial Wall or Membrane Synthesis
Antimicrobial Agents Affecting Bacterial Protein Synthesis
Antimicrobial Agents Affecting Topoisomerase
Miscellaneous Antibacterial Agents
Antimycobacterial Agents
Possible New Antibacterial Drugs
References and Further Reading
53 Antiviral drugs
Background Information About Viruses
The Host–Virus Interaction
HIV and AIDS
Antiviral Drugs
Combination Therapy for HIV
Prospects for New Antiviral Drugs
References and further reading
54 Antifungal drugs
Fungi and Fungal Infections
Drugs Used to Treat Fungal Infections
Future Developments
References and Further Reading
55 Antiprotozoal drugs
Background
Host–Parasite Interactions
Malaria and Antimalarial Drugs
Amoebiasis and Amoebicidal Drugs
Trypanosomiasis and Trypanocidal Drugs
Other Protozoal Infections and Drugs Used to Treat Them
Future Developments
References and Further Reading
56 Antihelminthic drugs
Helminth Infections
Antihelminthic Drugs
Resistance to Antihelminthic Drugs
Vaccines and Other Novel Approaches
References and Further Reading
57 Anticancer drugs
Introduction
The Pathogenesis of Cancer
General Principles of Cytotoxic Anticancer Drugs
Anticancer Drugs
Future Developments
References and Further Reading
Section 6 Special topics
58 Harmful effects of drugs
Introduction
Classification of Adverse Drug Reactions
Drug Toxicity
Immunological Reactions to Drugs
References and further reading
59 Lifestyle and drugs in sport
What Are Lifestyle Drugs?
Classification of Lifestyle Drugs
Drugs and Sex
Drugs in Sport
Conclusion
References and Further Reading
60 Drug discovery and development
The Stages of a Project
Biopharmaceuticals
Commercial Aspects
Future Prospects
A Final Word
References and Further Reading
Index
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Tags: James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang, Dale’s Pharmacology