Rang and Dale’s Pharmacology 9th edition by James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang ISBN 0702074489 ‎ 978-0702074486

Rang & Dale’s Pharmacology 9th edition by James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang – Ebook PDF Instant Download/Delivery: 0702074489 ‎, 978-0702074486
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Product details:

ISBN 10: 0702074489
ISBN 13: ‎ 978-0702074486
Author: James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang 

Comprehensive yet easy to use, Rang and Dale’s Pharmacology has been providing core basic and clinical science information to students and healthcare practitioners worldwide for more than 25 years. The fully revised 9th Edition keeps you up to date with all that’s new in the field, including new and emerging drugs and recent studies. From cover to cover, you’ll progressively increase your knowledge of all relevant aspects of pharmacology, from a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs.

• Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more.
• Includes access to unique features online, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment.
• Features a color-coded layout for faster navigation and cross-referencing.
• Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.
• Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Rang & Dale’s Pharmacology 9th Table of contents:

Section 1 General principles

1 What is pharmacology?

What Is a Drug?

Origins and Antecedents

Pharmacology in the 20Th and 21St Centuries

References and Further Reading

2 How drugs act

Introduction

Protein Targets for Drug Binding

Desensitisation and Tolerance

Quantitative Aspects of Drug–Receptor Interactions

The Nature of Drug Effects

References and Further Reading

3 How drugs act

Protein Targets for Drug Action

Receptor Proteins

Ion Channels as Drug Targets

Control of Receptor Expression

Receptors and Disease

References and Further Reading

4 How drugs act

Regulation of Intracellular Calcium

Excitation

Muscle Contraction

Release of Chemical Mediators

Epithelial Ion Transport

References and Further Reading

5 How drugs act

Introduction

Protein and Oligonucleotide Biopharmaceuticals

Oligonucleotides

Gene Therapy

Safety and Societal Issues

Therapeutic Applications

Concluding Remarks

References and Further Reading

6 Cell proliferation, apoptosis, repair and regeneration

Cell Proliferation

Angiogenesis

Apoptosis and Cell Removal

Pathophysiological Implications

Therapeutic Prospects

References and Further Reading

7 Cellular mechanisms

Introduction

The Innate Immune Response

The Adaptive Immune Response

Systemic Responses in Inflammation

References and Further Reading

8 Method and measurement in pharmacology

Bioassay

Animal Models of Disease

Pharmacological Studies in Humans

Clinical Trials

References and Further Reading

9 Absorption and distribution of drugs

Introduction

Physical Processes Underlying Drug Disposition

Drug Absorption and Routes of Administration

Distribution of Drugs in the Body

Special Drug Delivery Systems

References and Further Reading

10 Drug metabolism and elimination

Introduction

Drug and Metabolite Excretion

References and Further Reading

11 Pharmacokinetics

Introduction: Definition and Uses of Pharmacokinetics

Drug Elimination Expressed as Clearance

Single-Compartment Model

More Complicated Kinetic Models

Population Pharmacokinetics

Limitations of Pharmacokinetics

References and Further Reading

12 Individual variation, pharmacogenomics and personalised medicine

Introduction

Epidemiological Factors and Inter-Individual Variation of Drug Response

Genetic Variation in Drug Responsiveness

Therapeutic Drugs and Clinically Available Pharmacogenomic Tests

Conclusions

References and Further Reading

Section 2 Chemical mediators

13 Chemical mediators and the autonomic nervous system

Historical Aspects

The Autonomic Nervous System

Some General Principles of Chemical Transmission

Basic Steps in Neurochemical Transmission: Sites of Drug Action

References and Further Reading

14 Cholinergic transmission

Muscarinic and Nicotinic Actions of Acetylcholine

Acetylcholine Receptors

Nicotinic Receptors

Physiology of Cholinergic Transmission

Effects of Drugs on Cholinergic Transmission

References and Further Reading

15 Noradrenergic transmission

Catecholamines

Classification of Adrenoceptors

Physiology of Noradrenergic Transmission

Drugs Acting on Noradrenergic Transmission

References and Further Reading

16 5-Hydroxytryptamine and the pharmacology of migraine

5-Hydroxytryptamine

Migraine and Other Clinical Conditions in Which 5-HT Plays a Role

References and Further Reading

17 Purines

Introduction

Purinergic Receptors

Adenosine as a Mediator

ADP as a Mediator

ATP as a Mediator

Future Prospects

References and Further Reading

18 Local hormones 1

Introduction

What Is a ‘Mediator’?

Histamine

Eicosanoids

Leukotrienes

Other Important Fatty Acid Derivatives

Platelet-Activating Factor

Concluding Remarks

References and Further Reading

19 Local hormones 2

Introduction

General Principles of Protein and Peptide Pharmacology

Biosynthesis and Regulation of Peptides

Bradykinin

Neuropeptides

Cytokines

Proteins and Peptides That Down-Regulate Inflammation

Concluding Remarks

References and Further Reading

20 Cannabinoids

Plant-Derived Cannabinoids and Their Pharmacological Effects

Cannabinoid Receptors

Endocannabinoids

Synthetic Cannabinoids

Clinical Applications

References and Further Reading

21 Nitric oxide and related mediators

Introduction

Biosynthesis of Nitric Oxide and Its Control

Degradation and Carriage of Nitric Oxide

Effects of Nitric Oxide

Therapeutic Aspects

Clinical Conditions in Which Nitric Oxide May Play A Part

Related Mediators

References and Further Reading

Section 3 Drugs affecting major organ systems

22 The heart

Introduction

Physiology of Cardiac Function

Autonomic Control of the Heart

Cardiac Natriuretic Peptides

Ischaemic Heart Disease

Drugs That Affect Cardiac Function

References and Further Reading

23 The vascular system

Introduction

Vascular Structure and Function

Control of Vascular Smooth Muscle Tone

Vasoactive Drugs

Clinical Uses of Vasoactive Drugs

References and Further Reading

24 Atherosclerosis and lipoprotein metabolism

Introduction

Atherogenesis

Lipoprotein Transport

Prevention of Atheromatous Disease

Lipid-Lowering Drugs

References and Further Reading

25 Haemostasis and thrombosis

Introduction

Blood Coagulation

Drugs That Act on the Coagulation Cascade

Platelet Adhesion and Activation

Fibrinolysis (Thrombolysis)

References and Further Reading

26 Haematopoietic system and treatment of anaemia

Introduction

The Haematopoietic System

Types of Anaemia

Haematinic Agents

Haematopoietic Growth Factors

Haemolytic Anaemia

References and Further Reading

27 Anti-inflammatory and immunosuppressant drugs

Introduction

Cyclo-Oxygenase Inhibitors

Antirheumatoid Drugs

Anticytokine Drugs and Other Biopharmaceuticals

Drugs Used in Gout

Antagonists of Histamine

Possible Future Developments IN ANTIINFLAMMATORY THERAPY

References and Further Reading

28 Skin

Introduction

Structure of Skin

Common Diseases of the Skin

Drugs Acting on Skin

Principal Drugs Used in Skin Disorders

Agents Acting by Other Mechanisms

Concluding Remarks

References and Further Reading

29 Respiratory system

The Physiology of Respiration

Pulmonary Disease and Its Treatment

References and Further Reading

30 The kidney and urinary system

Introduction

Outline of Renal Function

The Structure and Function of the Nephron

Drugs Acting on the Kidney

Drugs That Alter the pH of the Urine

Drugs That Alter the Excretion of Organic Molecules

Drugs Used in Renal Failure

Drugs Used in Urinary Tract Disorders

References and Further Reading

31 The gastrointestinal tract

The Innervation and Hormones of the Gastrointestinal Tract

Gastric Secretion

Vomiting

The Motility of the GI Tract

Drugs for Chronic Bowel Disease

Drugs Affecting the Biliary System

Future Directions

References and Further Reading

32 The control of blood glucose and drug treatment of diabetes mellitus

Introduction

Control of Blood Glucose

Pancreatic Islet Hormones

Diabetes Mellitus

References and Further Reading

33 Obesity

Introduction

Obesity as a Health Problem

Homeostatic Mechanisms Controlling Energy Balance

The Pathophysiology of Human Obesity

Pharmacological Approaches to the Problem of Obesity

New Approaches to Obesity Therapy

References and Further Reading

34 The pituitary and the adrenal cortex

The Pituitary Gland

The Adrenal Cortex

New Directions in Glucocorticoid Therapy

References and Further Reading

35 The thyroid

Synthesis, Storage and Secretion of Thyroid Hormones

Regulation of Thyroid Function

Actions of the Thyroid Hormones

Transport and Metabolism of Thyroid Hormones

Abnormalities of Thyroid Function

Drugs Used in Diseases of the Thyroid

References and Further Reading

36 The reproductive system

Introduction

Endocrine Control of Reproduction

Drugs Affecting Reproductive Function

Drugs Used for Contraception

The Uterus

Erectile Dysfunction

References and Further Reading

37 Bone metabolism

Introduction

Bone Structure and Composition

Bone Remodelling

Disorders of Bone

Drugs Used in Bone Disorders

Potential New Therapies

References and Further Reading

Section 4 Nervous system

38 Chemical transmission and drug action in the central nervous system

Introduction

Chemical Signalling in the Nervous System

Targets for Drug Action

Drug Action in the Central Nervous System

The Classification of Psychotropic Drugs

References and Further Reading

39 Amino acid transmitters

Excitatory Amino Acids

Glutamate

γ-Aminobutyric Acid (GABA)

Glycine

Concluding Remarks

References and further reading

40 Other transmitters and modulators

Introduction

Noradrenaline

Dopamine

5-Hydroxytryptamine

Acetylcholine

Purines

Histamine

Other CNS Mediators

A Final Message

References and Further Reading

41 Neurodegenerative diseases

Protein Misfolding and Aggregation in Chronic Neurodegenerative Diseases

Mechanisms of Neuronal Death

Ischaemic Brain Damage

Alzheimer’s Disease

Parkinson’s Disease

Huntington’s Disease

Amyotrophic Lateral Sclerosis

Spinal Muscular Atrophy

Multiple Sclerosis

References and Further Reading

42 General anaesthetic agents

Introduction

Mechanism of Action of Anaesthetic Drugs

Intravenous Anaesthetic Agents

Inhalation Anaesthetics

Individual Inhalation Anaesthetics

Balanced Anaesthesia

References and Further Reading

43 Analgesic drugs

Neural Mechanisms of Pain

Analgesic Drugs

References and further reading

44 Local anaesthetics and other drugs affecting sodium channels

Local Anaesthetics

Other Drugs That Affect Sodium Channels

References and Further Reading

45 Anxiolytic and hypnotic drugs

The Nature of Anxiety and Its Treatment

Measurement of Anxiolytic Activity

Drugs Used to Treat Anxiety

Delayed Anxiolytic Effect of SSRIs and Buspirone

Drugs Used to Treat Insomnia (Hypnotic Drugs)

References and Further Reading

46 Antiepileptic drugs

Introduction

The Nature of Epilepsy

Antiepileptic Drugs

Muscle Spasm and Muscle Relaxants

References and Further Reading

47 Antipsychotic drugs

Introduction

The Nature of Schizophrenia

Antipsychotic Drugs

Future Developments

References and Further Reading

48 Antidepressant drugs

The Nature of Depression

Theories of Depression

Antidepressant Drugs

Clinical Effectiveness of Antidepressant Treatments

Future Antidepressant Drugs

Brain Stimulation Therapies

Drug Treatment of Bipolar Disorder

References and Further Reading

49 Psychoactive drugs

Introduction

Psychomotor Stimulants

Cognition-Enhancing Drugs

Psychedelic Drugs

Ketamine and Related Drugs

Depressants

Tolerance and Dependence

Synthetic Cannabinoids

References and Further Reading

50 Drug abuse and dependence

Drug Use and Abuse

References and Further Reading

Section 5 Drugs used for the treatment of infections and cancer

51 Basic principles of antimicrobial chemotherapy

Background

The Molecular Basis of Chemotherapy

Resistance to Antibacterial Drugs

Current Status of Antibiotic Resistance in Bacteria

References and Further Reading

52 Antibacterial drugs

Introduction

Antibacterial Agents That Interfere With Folate Synthesis or Action

β-Lactam Antibiotics and Other Agents That Interfere With Bacterial Wall or Membrane Synthesis

Antimicrobial Agents Affecting Bacterial Protein Synthesis

Antimicrobial Agents Affecting Topoisomerase

Miscellaneous Antibacterial Agents

Antimycobacterial Agents

Possible New Antibacterial Drugs

References and Further Reading

53 Antiviral drugs

Background Information About Viruses

The Host–Virus Interaction

HIV and AIDS

Antiviral Drugs

Combination Therapy for HIV

Prospects for New Antiviral Drugs

References and further reading

54 Antifungal drugs

Fungi and Fungal Infections

Drugs Used to Treat Fungal Infections

Future Developments

References and Further Reading

55 Antiprotozoal drugs

Background

Host–Parasite Interactions

Malaria and Antimalarial Drugs

Amoebiasis and Amoebicidal Drugs

Trypanosomiasis and Trypanocidal Drugs

Other Protozoal Infections and Drugs Used to Treat Them

Future Developments

References and Further Reading

56 Antihelminthic drugs

Helminth Infections

Antihelminthic Drugs

Resistance to Antihelminthic Drugs

Vaccines and Other Novel Approaches

References and Further Reading

57 Anticancer drugs

Introduction

The Pathogenesis of Cancer

General Principles of Cytotoxic Anticancer Drugs

Anticancer Drugs

Future Developments

References and Further Reading

Section 6 Special topics

58 Harmful effects of drugs

Introduction

Classification of Adverse Drug Reactions

Drug Toxicity

Immunological Reactions to Drugs

References and further reading

59 Lifestyle and drugs in sport

What Are Lifestyle Drugs?

Classification of Lifestyle Drugs

Drugs and Sex

Drugs in Sport

Conclusion

References and Further Reading

60 Drug discovery and development

The Stages of a Project

Biopharmaceuticals

Commercial Aspects

Future Prospects

A Final Word

References and Further Reading

Index

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Tags: James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang, Dale’s Pharmacology