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Sarcomere and Skeletal Muscle Disease The

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The Sarcomere and Skeletal Muscle Disease 1st Edition by Nigel G. Laing 9780387848471 0387848479

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Product details:

  • ISBN 10: 0387848479
  • ISBN 13: 9780387848471 
  • Author: Nigel G. Laing

Although best known for its role in heart disease, the sarcomere–the fundamental unit of muscle contraction–is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options.

Table contents:

  1. The Sarcomere and Sarcomerogenesis
  2. Nebulin—A Giant Chameleon
  3. Skeletal Muscle Disease Due to Mutations in Tropomyosin, Troponin and Cofilin
  4. Investigations into the Pathobiology of Thin-Filament Myopathies
  5. Mouse Models for Thin Filament Disease
  6. Thick Filament Diseases
  7. Acute Quadriplegic Myopathy: An Acquired “Myosinopathy”
  8. Third Filament Diseases
  9. The Z-Disk Diseases
  10. Intermediate Filament Diseases: Desminopathy
  11. Muscular Integrity—A Matter of Interlinking Distinct Structures via Plectin
  12. The Sarcomere and the Nucleus: Functional Links to Hypertrophy, Atrophy and Sarcopenia
  13. Other Model Organisms for Sarcomeric Muscle Diseases
  14. Therapeutic Approaches for the Sarcomeric Protein Diseases

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