Seizures and Epilepsy 2nd Edition by Jerome Engel Jr. – Ebook PDF Instant Download/Delivery: 0199370559, 978-0199370559
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ISBN 10: 0199370559
ISBN 13: 978-0199370559
Author: Jerome Engel Jr.
This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging.
According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. Basic scientists who are interested in learning more about clinical epileptology, as well as clinicians who would like to understand more about fundamental mechanisms will find this text useful. Residents and postdoctoral fellows, particularly those interested in a career in epilepsy, will benefit from the continuity and organization of this single-authored comprehensive textbook.
Seizures and Epilepsy 2nd Table of contents:
PART 1 INTRODUCTION
1. TERMINOLOGY AND CLASSIFICATIONS
TERMINOLOGY
CLASSIFICATIONS
SUMMARY AND CONCLUSIONS
2. PERSPECTIVES
EPILEPSY THEN—HISTORICAL PERSPECTIVE
EPILEPSY NOW—EPIDEMIOLOGICAL PERSPECTIVE
SUMMARY AND CONCLUSIONS
PART 2 PATHOPHYSIOLOGY
3. MECHANISMS OF NEURONAL EXCITATION AND SYNCHRONIZATION
THE NEURON
GLIAL INFLUENCES
NEURONAL NETWORKS
PHYLOGENY AND ONTOGENY
SYSTEMIC INFLUENCES
NEURONAL BASIS OF EEG ACTIVITY
METHODOLOGICAL DEVELOPMENTS
SUMMARY AND CONCLUSIONS
4. BASIC MECHANISMS OF SEIZURES AND EPILEPSY
EXPERIMENTAL MODELS OF SEIZURES AND EPILEPSY
STUDIES OF HUMAN EPILEPSY
MOLECULAR GENETIC INVESTIGATIONS
POSSIBLE MECHANISMS OF HUMAN EPILEPTIC PHENOMENA
SUMMARY AND CONCLUSIONS
5. CAUSES OF HUMAN EPILEPSY
NONSPECIFIC PREDISPOSING FACTORS
SPECIFIC EPILEPTOGENIC DISTURBANCES
PRECIPITATING FACTORS
SUMMARY AND CONCLUSIONS
PART 3 PHENOMENOLOGY
6. EPILEPTIC SEIZURES
NEUROBIOLOGICAL CONSIDERATIONS FOR THE DIAGNOSIS OF EPILEPTIC SEIZURE TYPES
TYPES OF EPILEPTIC SEIZURES
FOCAL SEIZURES
GENERALIZED SEIZURES
UNCLASSIFIED SEIZURES
MYOCLONUS
SUMMARY AND CONCLUSIONS
7. EPILEPSY SYNDROMES
NEONATAL PERIOD
INFANCY
CHILDHOOD
ADOLESCENCE-ADULT
SYNDROMES WITH LESS SPECIFIC AGE RELATIONSHIP
DISTINCTIVE CONSTELLATIONS
CONDITIONS WITH EPILEPTIC SEIZURES THAT ARE TRADITIONALLY NOT DIAGNOSED AS FORMS OF EPILEPSY PER SE
MYOCLONIC SYNDROMES
SUMMARY AND CONCLUSIONS
8. EPILEPTOGENESIS
THE DEVELOPMENT OF EPILEPSY
THE PROGRESSIVE NATURE OF EPILEPSY
EPILEPTIC SEIZURES AND BRAIN DEVELOPMENT
SUMMARY AND CONCLUSIONS
9. PERIICTAL PHENOMENA
ICTAL INITIATION
SLEEP-WAKE CYCLES AND CHRONOBIOLOGY
METABOLIC AND TOXIC INFLUENCES
PSYCHOLOGICAL STRESS
POSTICTAL SYMPTOMS
MORTALITY
SUMMARY AND CONCLUSIONS
10. STATUS EPILEPTICUS
GENERALIZED CONVULSIVE STATUS EPILEPTICUS
ABSENCE STATUS EPILEPTICUS
EPILEPSIA PARTIALIS CONTINUA
FOCAL DYSCOGNITIVE (COMPLEX PARTIAL) STATUS EPILEPTICUS
SUBTLE STATUS EPILEPTICUS
FEBRILE STATUS EPILEPTICUS
NEONATAL STATUS EPILEPTICUS
EPILEPTIC BRAIN DAMAGE
SUMMARY AND CONCLUSIONS
11. CHRONIC BEHAVIORAL DISTURBANCES
EPIDEMIOLOGY OF PSYCHIATRIC COMORBIDITY IN EPILEPSY
PHENOMENOLOGY OF BEHAVIORAL DISTURBANCES IN EPILEPSY
MECHANISMS OF INTERICTAL BEHAVIORAL DISTURBANCES IN EPILEPSY
SUMMARY AND CONCLUSIONS
PART 4 MANAGEMENT
12. DIAGNOSTIC EVALUATION
HISTORY
PHYSICAL EXAMINATION
LABORATORY EXAMINATION
PSYCHOLOGICAL EVALUATION
BIOMARKERS
SUMMARY AND CONCLUSIONS
13. DIFFERENTIAL DIAGNOSIS
DIFFERENTIAL DIAGNOSIS OF NONEPILEPTIC PAROXYSMAL EVENTS
DIFFERENTIAL DIAGNOSIS OF REACTIVE (ACUTE SYMPTOMATIC, PROVOKED) EPILEPTIC SEIZURES
DIFFERENTIAL DIAGNOSIS OF CHRONIC EPILEPSY
USE OF THE EEG IN THE DIFFERENTIAL DIAGNOSIS OF EPILEPSY
USE OF FUNCTIONAL IMAGING IN THE DIFFERENTIAL DIAGNOSIS OF EPILEPSY
SUMMARY AND CONCLUSIONS
14. GENERAL PRINCIPLES OF TREATMENT
PHARMACOLOGICAL TREATMENT
MEDICALLY REFRACTORY SEIZURES
ALTERNATIVE THERAPY
PSYCHOSOCIAL CONSIDERATIONS
USE OF EEG IN ASSESSING TREATMENT
MANAGEMENT AFTER A SINGLE SEIZURE
EMERGENCY TREATMENT
SUMMARY AND CONCLUSIONS
15. ANTISEIZURE DRUGS
STANDARD OLDER DRUGS
NEWER DRUGS
SPECIAL AND RARELY USED DRUGS
NEW-DRUG DEVELOPMENT
DRUGS UNDER INVESTIGATION
SUMMARY AND CONCLUSIONS
16. NONPHARMACOLOGICAL THERAPY OF SEIZURES
SURGICAL THERAPY
VAGUS NERVE STIMULATION
HORMONE THERAPY
IMMUNE THERAPY
COMPLEMENTARY AND ALTERNATIVE MEDICINE
SUMMARY AND CONCLUSIONS
17. SOCIAL MANAGEMENT
STIGMA
QUALITY OF LIFE
ACTIVITIES OF DAILY LIVING
FAMILY
SCHOOL
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