Textbook of Pediatric Rheumatology 8th edition by Ross Petty, Ronald Laxer, Carol Lindsley, Lucy Wedderburn, Robert Fuhlbrigge, Elizabeth ISBN 0323636543 9780323636544
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Textbook of Pediatric Rheumatology 8th edition by Ross Petty, Ronald Laxer, Carol Lindsley, Lucy Wedderburn, Robert Fuhlbrigge, Elizabeth – Ebook PDF Instant Download/Delivery: 0323636543, 9780323636544
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ISBN 10: 0323636543
ISBN 13: 9780323636544
Author: Ross Petty, Ronald Laxer, Carol Lindsley, Lucy Wedderburn, Robert Fuhlbrigge, Elizabeth
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease.
Textbook of Pediatric Rheumatology 8th Table of contents:
Section I: Basic Concepts
-
Structure and Function
- The Skeleton
- Tendons
- Ligaments and Fascia
- Entheses
- Bursae
- Skeletal Muscle
-
Genetics and Pediatric Rheumatic Diseases
- Introduction
- Genes, Variation, and the Human Genome Sequence in Biomedical Research
- Techniques for Genetic and Genomic Investigation
- Approaches for Investigating Monogenic Pediatric Rheumatic Disease
- Approaches for Investigating Polygenic Pediatric Rheumatic Disease
- Candidate Gene Studies in Pediatric Rheumatology
- Transmission Disequilibrium Testing
- Genome-Wide Association Studies
- Genome Editing
-
Mechanistic Investigation of Pediatric Rheumatic Diseases
- Introduction
- The Essence of a Test
- Genetic and Epigenetic Investigations
- Cellular Characterization and Enumeration
- Protein Quantitation and Proteomics
- Quantitating RNA
- Assessment of Microbial Populations
- Summary
-
Inflammation and Its Mediators
- Cells of Innate Immunity
- The Inflammatory Response
- When Defective Regulation of Innate Immunity Leads to Rheumatic Disease
-
Adaptive Immunity and Autoimmunity
- Introduction to Adaptive Immunity
- T Cells
- B Cells
- Antigen Presentation
- Conclusions
-
Understanding Clinical Investigations
- Truth, Levels of Evidence, and Evidence-Based Medicine
- Types of Clinical Investigations
- Basic Concepts
- Study Design
- Describing Data
- Paradigms of Inference
- Concepts and Terminology for Communicating Study Results
- Basic Tests of Association
- Advanced Data Analyses
- Assessing and Interpreting Results
- Assessing the Quality of Clinical Investigations
-
Clinical Outcome Measures in Pediatric Rheumatic Diseases
- Introduction
- Juvenile Idiopathic Arthritis
- Systemic Lupus Erythematosus
- Juvenile Dermatomyositis
- Scleroderma
- Systemic Vasculitis
- Parent- and Child-Reported Outcomes
- Conclusions
-
Pain and Its Assessment
- Introduction
- Biopsychosocial Model of Pain
- Assessment of Pain
- Treatment of Pain
- Future Directions
-
Imaging in Pediatric Rheumatic Diseases
- Introduction
- Imaging Modalities: Technical Aspects
- Physiological Findings, Normal Variants, and Reference Standards
- Inflammatory Arthritis
- Enthesitis-Related Arthritis/Spondylarthopathies
- Psoriatic Arthritis
- Imaging Findings In Juvenile Dermatomyositis
-
Laboratory Investigations
- Introduction
- Laboratory Methods
- Tests
- Other Laboratory Investigations
- The Future
-
Principles in the Management of Patients with Rheumatic Disease
- Introduction
- General Approach to Management
- Other Important Topics
- Future Endeavors
- Summary
- Resources for Further Information on Rheumatic Diseases for Patients and Parents
-
Global Issues in Pediatric Rheumatology
- Epidemiology
- Challenges in Diagnosis and Management
- Strategies to Improve Outcomes
-
Therapeutics: Nonbiologics
- Concepts in Pharmacology
- Antirheumatic Drugs
- Therapeutics for Amplified Pain
-
Therapeutics: Biologics and Small Molecules
- General Considerations
- Intravenous Immunoglobulin
- Inhibition Of T Cell Costimulation
- B-Cell Targeted biological DMARDs
- Interference With Cytokines
- Targeted Synthetic Therapies/Small Molecules
- Kinase Inhibitors
- Biosimilars Versus Biocopies Versus Me-Too Drugs
- Stem-Cell And Mesenchymal Stem-Cell Transplantation
-
Nonmedical Therapies in Pediatric Rheumatic Diseases
- Joint and Muscle Health
- Epidemiology of Joint and Muscle Health in Pediatric Rheumatic Conditions
- Improving Joint and Muscle Health
- Motor Development and Motor Performance
- Physical Activity Level and Exercise Tolerance
- Psychosocial and Occupational Health
- Additional Aspects of Health
- Summary
Section II: Inflammatory Joint Disease and Related Conditions
-
Juvenile Idiopathic Arthritis: Classification and Basic Concepts
- Historical Aspects
- Classifications of Chronic Childhood Arthritis
- Epidemiology
- Genetic Associations
- Clinical Manifestations of JIA
- Pathology
- Imaging
- Burden of Disease
-
Systemic Juvenile Idiopathic Arthritis
- Epidemiology
- Etiology and Pathogenesis
- Clinical Manifestations
- Diagnosis and Differential Diagnosis
- Pathology
- Laboratory Examination
- Radiological Examination
- Treatment
- Course of the Disease and Prognosis
-
Polyarticular Juvenile Idiopathic Arthritis
- Definitions
- RF-Negative Polyarticular JIA
- Rheumatoid Factor Positive Polyarthritis
-
Oligoarticular Juvenile Idiopathic Arthritis
- Definition
- Epidemiology
- Genetics
- Etiology and Pathogenesis
- Clinical Manifestations
- Laboratory Evaluation
- Radiographic Evaluation
- Pathology
- Diagnosis
- Treatment
- Disease Course and Prognosis
- Perspective
-
Enthesitis-Related Arthritis
- Definition and Classification
- Epidemiology
- Etiology
- Pathogenic Mechanisms
- Clinical Manifestations
- Pathology
- Differential Diagnosis
- Laboratory Examination
- Radiological Examination
- Whole-Body MRI
- Treatment
- Course of the Disease and Prognosis
-
Psoriatic Juvenile Idiopathic Arthritis
- Definition and Classification
- Epidemiology
- Etiology, Pathology, and Pathogenesis
- Pathology
- Pathogenesis
- Clinical Manifestations
- Laboratory Examination
- Radiologic Examination
- Treatment
- Course and Prognosis
-
Uveitis in Juvenile Idiopathic Arthritis
- Classification of Uveitis
- Uveitis in Juvenile Idiopathic Arthritis
- Laboratory Examination
- Management
- Disease Course and Prognosis
Section III: Inflammatory Connective Tissue Disease
-
Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
- Systemic Lupus Erythematosus
- Epidemiology
- Etiology and Pathogenesis
- Clinical Disease Presentation
- Outcomes and Prognosis in Lupus Nephritis
- Other Renal Manifestation of SLE
- Skin Pathology
- Treatment of Skin Disease
- Treatment of Neuropsychiatric-SLE
- Other Cardiac Manifestations of SLE
- Hematological Involvement
- Vasculitis
- Approach to the Child With SLE
- General Laboratory Evaluation
- Treatment
- Morbidity and Mortality
- Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease
- Mixed Connective Tissue Disease: Definition and Classification
- Undifferentiated Connective Tissue Disease and Overlap Syndromes
- Systemic Lupus Erythematosus
-
Antiphospholipid Syndrome
- Definition and Classification
- Epidemiology
- Etiology and Pathogenesis
- Genetic Background
- Clinical Manifestations
- Pathology
- Diagnosis and Differential Diagnosis
- Laboratory Examination
- Radiologic Examination
- Treatment
- Course of the Disease and Prognosis
-
Neonatal Lupus Erythematosus
- Etiology and Pathogenesis
- Clinical Features
- Long-Term Risk of Autoimmune Disease
-
Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases
- Epidemiology
- Causes and Pathogenesis
- Clinical Manifestations
- Classification and Diagnostic Criteria
- Laboratory Examination/Investigations
- Differential Diagnosis
- Treatment
- Clinical Assessment
- Course of the Disease and Prognosis
- Complications
-
Juvenile Systemic Sclerosis
- Introduction
- Demographics and Epidemiology
- Etiology and Pathogenesis
- Diagnosis and Classification of Juvenile Systemic Sclerosis
- Clinical Features
- Patient-Reported Outcomes
- Systemic Sclerosis Treatment
- Raynaud Phenomenon
- Digital Ulcers
- The Future of Treatment in Pediatric Systemic Sclerosis
- Prognosis
-
Localized Scleroderma and Eosinophilic Fasciitis
- Historical Review
- Definition and Classification
- Epidemiology
- Etiology and Pathogenesis
- Pathology
- Differential Diagnosis
- Laboratory Examination
- Treatment of Localized Scleroderma
- Course of the Disease and Prognosis
-
Sjögren Syndrome and Immunoglobulin-G4 Disease
- Sjögren Syndrome
- Definition and Epidemiology
- Classification
- Clinical Manifestations
- Pathology
- Pathogenesis
- Laboratory Examination
- Imaging Studies
- Management
- Outcome Measures
- Prognosis and Outcome
- IgG4-Related Diseases
- Sjögren Syndrome
-
Raynaud Phenomenon and Vasomotor Syndromes
- Introduction
- Clinical Presentation
- Diagnosis
- Differential Diagnosis
- Treatment of Raynaud Phenomenon
- Management of Digital Ischemia
- Erythromelalgia
- Summary and Future Directions
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Ross Petty,Ronald Laxer,Carol Lindsley,Lucy Wedderburn,Robert Fuhlbrigge,Elizabeth,Pediatric Rheumatology
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