Yen and Jaffe’s Reproductive Endocrinology Physiology Pathophysiology and Clinical Management 8th edition by Jerome Strauss, Robert Barbieri ISBN 032347912X ‎ 978-0323479127

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ISBN 10:  032347912X
ISBN 13: ‎ 978-0323479127
Author: Jerome Strauss, Robert Barbieri 

Now celebrating its 40th anniversary, Yen & Jaffe’s Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field.

• Covers key topics such as the role of genetics in reproductive endocrinology, environmental factors in reproductive endocrinology, and recent advances in surgical procedures.
• Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction.
• Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy.
• Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section.
• Includes a new online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Videos cover Disorders of Sex Development, Endometriosis, Benign Uterine Disorders, Gamete and Embryo Manipulation, and Fertility Preservation.
• Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Yen & Jaffe’s Reproductive Endocrinology Physiology Pathophysiology and Clinical Management 8th Table of contents:

Part 1 Endocrinology of Reproduction

Chapter 1 Neuroendocrinology of Reproduction

Central Control of Reproduction

Neuroendocrinology: The Interface Between Neurobiology and Endocrinology

References

Chapter 2 Gonadotropin Hormones and Their Receptors

Gonadotropins

Gonadotropin Proteins (LH, hCG, and FSH)

Structure-Function Studies

Genes and Transcripts

Expression and Secretion of the Gonadotropins

Gonadotropin Receptors

Gonadotropin Receptor Proteins

Gene Expression and Regulation

Signaling Pathways Mediated by Gonadotropin Receptors

Mutations and Polymorphisms of the Gonadotropin Receptor Genes

Low-Molecular-Weight Gonadotropin Receptor Agonists and Antagonists

References

Chapter 3 Prolactin and Its Role in Human Reproduction

Lactotroph Development

Prolactin Gene

Prolactin Synthesis in Pituitary Lactotrophs

Prolactin Synthesis in the Decidua and Other Tissues

Prolactin Assays

Prolactin Secretion

Regulation of Systemic Prolactin Levels

Prolactin Actions

Pathologic States of Prolactin Deficiency and Excess

Prolactin-Secreting Pituitary Adenomas (Prolactinomas)

Pregnancy and Prolactinomas

References

Chapter 4 Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction

Steroid Hormones: Structure and Nomenclature

Organization of Steroidogenic Organs and Cells

Acquisition, Storage, and Trafficking of Cholesterol

Regulation of Cellular Cholesterol Balance

Overview of Steroidogenesis

Other Steroid Hormone Metabolic Pathways

Regulation of Expression of the Steroidogenic Machinery

Examples of Extraglandular Steroidogenesis

Secretion, Production, and Metabolic Clearance Rates of Steroid Hormones

Plasma Steroid Hormone–Binding Proteins

Inhibitors of Enzymes Involved in Synthesis or Metabolism of Sex Steroids

Eicosanoids: Other Bioactive Lipids Playing a Role in Reproduction

Major Products of the COX Pathway: Prostaglandins, Thromboxanes, and Prostacyclin

Major Products of the Lipoxygenase Pathway: The Leukotrienes and HETEs

Transport and Metabolism of Eicosanoids

Pharmacologic Regulation of Eicosanoid Synthesis

Eicosanoid Receptors

Eicosanoids and Reproduction

References

Chapter 5 Steroid Hormone Action

Steroid Hormone Receptors Act as Ligand-Dependent Transcription Factors or Repressors

Evolution of Steroid Hormone Receptor Structure and Function

Steroid Hormone Receptor Function

General Factors That Influence Steroid Hormone Action

Nongenomic Actions of Steroids

Summary

References

Chapter 6 Growth Factors and Reproduction

Ovary Development

Formation of the Reproductive Tracts

Growth Factors in Uterine Biology

Growth Factor Pathways in Male Reproduction

Conclusion

Acknowledgments

References

Chapter 7 Neuroendocrine Control of the Menstrual Cycle

Reproductive Axis

Normal Menstrual Cycle

References

Chapter 8 Ovarian Life Cycle

Introduction

Primordial Germ Cells

Ovarian Morphogenesis

Epigenetic Programming and Germ Cell Development

The Follicle and Its Surroundings

Ovarian Stem Cells

Follicular Life Cycle

Ovarian Aging and Insufficiency

Assessment of Ovarian Reserve and Prediction of Reproductive Age

Endocrine Activity of the Postmenopausal Ovary

References

Chapter 9 Structure, Function, and Evaluation of the Female Reproductive Tract

Structure and Function

Menstrual Cycle

Endometrium in the Cycle of Conception and Pregnancy

Clinical Evaluation of the Endometrium

Endometrium in Advancing Age

Uterine Transplantation

References

Chapter 10 Breast

Structural Features of the Breast

Development of the Breast

Mammary Stem Cells

Estradiol and Testosterone: Dueling Steroids

Lactation and Breastfeeding

Benign Breast Disease

References

Chapter 11 Endocrinology of Human Pregnancy and Fetal-Placental Neuroendocrine Development

Introduction

Establishment of Pregnancy

Endocrine Placenta

Fetal Neuroendocrine Systems

Fetal Maturation and Timing of Parturition

Evolutionary Perspective on Human Pregnancy

References

Chapter 12 Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs

Physiology of the Male Gonadal Axis

Testicular Steroidogenesis

Sex-Steroid Receptors and Sex Hormone-Binding Globulin

Physiology of Hypothalamo-Pituitary-Testicular Network

Testis

Accessory Organs

Spermatogenesis

Regulation of Male Fertility

Decremental Changes in Gonadotropin-Releasing Hormone-Luteinizing Hormone-Testosterone Axis in Aging

Acknowledgments

References

Chapter 13 Immunology and Reproduction

Basic Immune Principles

Alloimmunity and Reproduction

Autoimmunity and Reproduction

Conclusion

References

Chapter 14 Menopause and Aging

Epidemiology

Premature Ovarian Failure

Menopausal Transition (Perimenopause)

Effects on Various Organ Systems

Breast Cancer

Decision to Use Estrogen

Endometrial Disease Risk and Other Cancers

Hormone Regimens

Aging

References

Chapter 15 Male Reproductive Aging

Changes in Male Reproductive Function with Age

Consequences of Decreased Serum Testosterone Concentrations

Attempts to Reverse the Consequences of Aging by Testosterone Treatment

Conclusion

References

Part 2 Pathophysiology and Therapy: Pediatric, Adolescent, and Adult

Chapter 16 Disorders of Sex Development

Mechanisms of Human Sex Development

Sex Chromosome Disorders of Sex Development

46,XY Disorders of Sex Development

46,XX Disorders of Sex Development

General Management for Patients With Disorders/Differences of Sex Development

References

Chapter 17 Puberty

Introduction

Stages of Pubertal Development, Secular Trends, and Racial and Ethnic Differences

Physiology of Puberty

Neurobiology of Gonadarche

Activation and Timing of Adrenarche

Genetics and Puberty Genes

Factors Modulating the Timing of Puberty

Disorders of Puberty

Conclusion

Acknowledgment

References

Chapter 18 Nutrition and Reproduction

Nutrition and Puberty

How Does Fat Signal the HPO Axis?

How Does Body Weight Modify Puberty and Adult Reproduction?

Adult Obesity and Reproduction

Nutrition in the Young Oncology Patient

Summary

Conclusion

References

Chapter 19 Environmental Factors and Reproduction

Introduction: Reproductive Health and the Environment

Definition

Reproductive Health Professional Society Engagement on Environmental Health

Key Scientific Concepts

Human Exposure to Environmental Chemicals

Mechanisms

Reproductive Health Outcomes Linked to Environmental Chemical Exposures

Evidence-Based Decision Making in Environmental Health

Clinical Management

Health Care System and Public Policy Solutions

Conclusion

Acknowledgments

Recommended Online Resources

References

Chapter 20 Physiologic and Pathophysiologic Alterations of the Neuroendocrine Components of the Reproductive Axis

Hypothalamic Dysfunction

Pituitary Dysfunction

References

Chapter 21 Polycystic Ovary Syndrome and Hyperandrogenic States

Diagnostic Criteria

Epidemiology

Clinical Description

Fetal Origin of Polycystic Ovary Syndrome

Polycystic Ovary Syndrome in Adolescence

Altered Physiology

Adrenal Function

Genetics of Polycystic Ovary Syndrome

Long-Term Consequences

Differential Diagnosis

Evaluation

Treatment

References

Chapter 22 Female Infertility

Statistical Model of Infertility

Diseases Associated With Infertility

Initial Infertility Evaluation

Abnormalities in Oocyte Production

Hyperprolactinemia

Anatomical Factors in the Female

Immunologic Factors and Recurrent Abortion

Genetic Causes of Infertility

Unexplained Infertility

Environmental Exposures Associated With Infertility

Contraindications to Infertility Treatment

Infertility Treatment and Pregnancy Outcomes

Adoption

Psychosocial Aspects of Infertility

Social and Ethical Issues

Insurance Against Female Infertility Due to Advancing Age

References

Chapter 23 Male Infertility

Introduction

Evaluation of Male Infertility

Low Semen Volume

Oligospermia/Asthenospermia/Teratospermia

Azoospermia

Management of Male Infertility

Hormone Optimization

Ejaculatory Dysfunction

Ejaculatory Duct Obstruction

Pyospermia

Immunological Infertility

Varicocele Repair

Vasal Reconstruction

Assisted Reproductive Techniques

Conclusion

References

Chapter 24 Endocrine Disturbances Affecting Reproduction

Pituitary Disorders

Adrenal Disorders

Thyroid Disorders

References

Chapter 25 Endometriosis

Introduction

Key Clinical Observations

Key Experimental Observations

Epidemiology

Pathology

Pathophysiology

Clinical Aspects

References

Chapter 26 Benign Uterine Diseases

Uterine Leiomyomas

Principles of Treatment

Adenomyosis

Endometrial Polyps

Abnormal Uterine Bleeding

Intrauterine Adhesions

Dysmenorrhea

References

Chapter 27 Endocrine Diseases of Pregnancy

Diabetes Mellitus

Obesity and Pregnancy

Hypothalamic-Pituitary Diseases

Disorders of Thyroid Function

Disorders of Calcium Metabolism

Adrenal Diseases

Congenital Adrenal Hyperplasia

Pheochromocytoma

Ovarian Endocrine Tumors

Preeclampsia

Parturition

Preterm Birth

Postterm Pregnancy

References

Chapter 28 Transgender Hormonal Treatment

Introduction

Diagnosis

Hormonal Treatment for Transgender Individuals

Surgical Treatment for Transgender Individuals

Concerns of Therapy and Screening for Malignancy

Children and Adolescents

Fertility Preservation

Barriers to Care

Conclusion

References

Chapter 29 Hormone-Responsive Cancers

Breast Cancer

Prostate Cancer

Endometrial Carcinoma

References

Part 3 Reproductive Technologies

Chapter 30 Medical Approaches to Ovarian Stimulation for Infertility

Concepts of Ovarian Stimulation

Concepts of Follicle Development Relevant to Ovarian Stimulation

Preparations Used for Ovarian Stimulation

Outcomes of Ovarian Stimulation

Induction of Ovulation in Anovulatory Women

Preparations for Treating Anovulation

Ovarian Stimulation in the Empirical Treatment of Unexplained Subfertility

Preparations for Ovarian Stimulation

Ovarian Stimulation for In Vitro Fertilization

Clinical Outcome of In Vitro Fertilization

Health Economics of Ovarian Stimulation

Conclusions and Future Perspective

References

Chapter 31 Assisted Reproduction

Introduction

Brief History of Assisted Reproductive Technologies

Physiology of Sexual Reproduction

Pre–In Vitro Fertilization Evaluation

Indications for In Vitro Fertilization

Overview of In Vitro Fertilization Statistics

Patient Counseling for In Vitro Fertilization

Ovarian Stimulation

Oocyte Retrieval

Collection, Assessment, and Preparation of Sperm

Incubation of Sperm With Oocytes, Intracytoplasmic Sperm Injection, and the Fertilization Check

Embryo Culture Systems

Evaluating Embryo Quality

Embryo Transfer

Luteal Phase Support in Fresh Transfers

Embryo Cryopreservation

Repeat In Vitro Fertilization Cycles

Third Party Reproduction

Emerging Technologies Involving Three Patient In Vitro Fertilization

In Vitro Fertilization Risks and Their Management

Obstetric, Neonatal, and Childhood Outcomes Following In Vitro Fertilization

Environmental Exposures and Lifestyle Factors in Assisted Reproductive Technologies

Concluding Remarks

References

Chapter 32 Gamete and Embryo Manipulation

Laboratory Environment

Gamete Handling

Fertilization

Assessment of Fertilization

Grading

Improving Implantation Rates

Cryopreservation of Human Oocyte, Embryo, Ovarian Tissue, and Sperm

References

Chapter 33 Fertility Preservation

Introduction

Fertility Preservation in Both Nononcologic and Oncologic Conditions

Oncofertility Medical Management

Emerging Fertility Preservation Techniques

Oncofertility Patient Management

Summary and Future Outlook

Acknowledgments

References

Chapter 34 Evaluation of Hormonal Status

Introduction

Principles of Hormone Assays

Measurement of Specific Reproductive Protein and Peptide Hormones and Steroid Hormones

Measurement of Anti-Müllerian Hormone

Measurement of Inhibins

Assessment of Ovarian Reserve

Measurement of Human Chorionic Gonadotropin

Assessment of Glucose Metabolism, Insulin Activity, and Adipose Mass

Measurement of Growth Hormone and Growth Factors

Measurement of Calcium-Regulating Hormones and Bone Markers

Measurement and Blood Levels of Thyroid Hormones

Evaluation of Glucocorticoid Adrenal Function

Diagnostic Procedure in Suspected Pituitary Tumors

Pelvic Evaluation

References

Chapter 35 Pelvic Imaging in Reproductive Endocrinology

Ultrasound Examination Technique

PALM-COEIN

Postmenopausal Bleeding

Müllerian Anomalies

Ovarian Assessment

Assessment of Fallopian Tube Patency

Evaluation of Deeply Invasive Endometriosis

Early Pregnancy

Conclusion

References

Chapter 36 Contraception

Introduction

Contraceptive Effectiveness Versus Efficacy

Long-Acting Reversible Contraceptives

Oral Contraceptive Pills

Postcoital Contraceptives

Transdermal Contraceptive System

Contraceptive Vaginal Ring

Injectable Contraceptives

Spermicides and Barrier Methods

Contraception and Malignancy

Contraception for Special Populations

References

Index

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